The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain

The 2-oxoglutarate dehydrogenase (OGDH) multienzyme complex is rate-limiting in the TCA cycle in many species, and is an essential nexus in the utilization of sugar and amino acids, funnelled via 2-oxoglutarate and oxidized to succinyl-CoA, process which releases CO2 and results in the reduction of NAD+ to NADH PMID:17367808.

An alternative name for this complex is alpha-ketoglutarate dehydrogenase (KGD). Structural domains comprising this superfamily are found at the C-terminus of the multifunctional 2-oxoglutarate metabolism enzyme KGD PMID:21867916.

GO Diversity

Unique GO annotations
47 Unique GO terms

EC Diversity

Unique EC annotations
4 Unique EC terms

Species Diversity

Unique species annotations
8106 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 49
Domain clusters (>95% seq id): 2
Domain clusters (>35% seq id): 1
Unique PDBs: 16
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 40
Unique EC: 4
Unique GO: 47
Unique Species: 8106