The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Sialyltransferase, C-terminal GT-B Rossman nucleotide-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Sialyltransferase, C-terminal GT-B Rossman nucleotide-binding domain

Sialyltransferases are enzymes that catalyse the transfer of sialic acid from its activated sugar nucleotide form, cytidine 5'-monophosphate sialic acid (CMP-sialic acid or CMP-Sia), to the terminal positions of glycans on glycoproteins and glycolipids.

The second and third domains in certain sialyltransferases resemble the Rossmann nucleotide-binding domain. Together, these two domains form a structure found in the glycosyltransferase B (GT-B) superfamily, and hence they are named N-terminal GT-B and C-terminal GT-B domains. A deep nucleotide-binding cleft is formed between the two domains that can accommodate substrate molecules of varied sizes and diverse structures and exhibits a large conformational change of the enzyme upon binding to CMP.

This superfamily entry is representative for the C-terminal GT-B glycosyltransferase B Rossman nucleotide-binding domain.

DOI:10.1016/j.febslet.2014.11.003,DOI:10.1021/bi0524013

GO Diversity

Unique GO annotations
0 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
227 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 33
Domain clusters (>95% seq id): 5
Domain clusters (>35% seq id): 2
Unique PDBs: 24
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 0
Function
Unique EC:
Unique GO:
Taxonomy
Unique Species: 227