The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 7: L-threonine dehydratase catabolic TdcB

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 38 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
L-serine ammonia-lyase activity GO:0003941
Catalysis of the reaction: L-serine = pyruvate + NH3.
163 O59791 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA)
(153 more)
Pyridoxal phosphate binding GO:0030170
Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.
161 A4F2N8 (/IDA) A4F2N8 (/IDA) O59791 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA)
(151 more)
Threonine aldolase activity GO:0004793
Catalysis of the reaction: L-threonine = glycine + acetaldehyde.
155 P0AGF6 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA)
(145 more)
L-threonine ammonia-lyase activity GO:0004794
Catalysis of the reaction: L-threonine = 2-oxobutanoate + NH3.
155 P0AGF6 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA)
(145 more)
Amino acid binding GO:0016597
Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents.
155 P0AGF6 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA)
(145 more)
D-serine ammonia-lyase activity GO:0008721
Catalysis of the reaction: D-serine = pyruvate + NH3.
7 O59791 (/IDA) Q2PGG3 (/IDA) Q7XSN8 (/IDA) Q7XSN8 (/IDA) Q7XSN8 (/IDA) Q7XSN8 (/IDA) Q7XSN8 (/IDA)
Serine racemase activity GO:0030378
Catalysis of the synthesis of free D-serine from L-serine.
6 O59791 (/IDA) Q2PGG3 (/IDA) Q54HH2 (/IDA) Q76EQ0 (/IDA) Q9GZT4 (/IDA) Q9QZX7 (/IDA)
Threo-3-hydroxyaspartate ammonia-lyase activity GO:0030848
Catalysis of the reaction: (3S)-3-hydroxy-L-aspartate = NH(4)(+) + oxaloacetate.
5 A4F2N8 (/IDA) A4F2N8 (/IDA) P36007 (/IDA) P36007 (/IDA) P36007 (/IDA)
Protein self-association GO:0043621
Interacting selectively and non-covalently with a domain within the same polypeptide.
5 Q7XSN8 (/IDA) Q7XSN8 (/IDA) Q7XSN8 (/IDA) Q7XSN8 (/IDA) Q7XSN8 (/IDA)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
4 O59791 (/IDA) Q76EQ0 (/IDA) Q9GZT4 (/IDA) Q9QZX7 (/IDA)
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
3 O59791 (/IDA) Q76EQ0 (/IDA) Q9GZT4 (/IDA)
Serine racemase activity GO:0030378
Catalysis of the synthesis of free D-serine from L-serine.
3 A0JNI4 (/ISS) Q2PGG3 (/ISS) Q9VHF0 (/ISS)
Threo-3-hydroxyaspartate ammonia-lyase activity GO:0030848
Catalysis of the reaction: (3S)-3-hydroxy-L-aspartate = NH(4)(+) + oxaloacetate.
3 P36007 (/IMP) P36007 (/IMP) P36007 (/IMP)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
3 O59791 (/IPI) Q76EQ0 (/IPI) Q9GZT4 (/IPI)
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
2 A0JNI4 (/ISS) Q54HH2 (/ISS)
L-threonine ammonia-lyase activity GO:0004794
Catalysis of the reaction: L-threonine = 2-oxobutanoate + NH3.
2 A0A0F7RFZ2 (/ISS) A0A0F7RFZ2 (/ISS)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
2 A0JNI4 (/ISS) Q9GZT4 (/ISS)
Pyridoxal phosphate binding GO:0030170
Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.
2 A0JNI4 (/ISS) Q9GZT4 (/ISS)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 Q9GZT4 (/IDA) Q9QZX7 (/IDA)
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
1 Q9QZX7 (/ISO)
L-serine ammonia-lyase activity GO:0003941
Catalysis of the reaction: L-serine = pyruvate + NH3.
1 Q9QZX7 (/ISO)
L-serine ammonia-lyase activity GO:0003941
Catalysis of the reaction: L-serine = pyruvate + NH3.
1 Q4QJ04 (/RCA)
L-threonine ammonia-lyase activity GO:0004794
Catalysis of the reaction: L-threonine = 2-oxobutanoate + NH3.
1 Q4QJ04 (/RCA)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
1 Q9QZX7 (/IDA)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
1 Q9GZT4 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 Q9QZX7 (/IPI)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
1 Q9QZX7 (/ISO)
Glycine binding GO:0016594
Interacting selectively and non-covalently with glycine, aminoethanoic acid.
1 Q9QZX7 (/IDA)
Glycine binding GO:0016594
Interacting selectively and non-covalently with glycine, aminoethanoic acid.
1 Q9GZT4 (/ISS)
Lyase activity GO:0016829
Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
1 Q10725 (/IDA)
Threonine racemase activity GO:0018114
Catalysis of the reaction: L-threonine = D-threonine.
1 Q9QZX7 (/IDA)
Threonine racemase activity GO:0018114
Catalysis of the reaction: L-threonine = D-threonine.
1 Q9GZT4 (/ISS)
PDZ domain binding GO:0030165
Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins.
1 Q9GZT4 (/IPI)
PDZ domain binding GO:0030165
Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins.
1 Q9QZX7 (/ISO)
Pyridoxal phosphate binding GO:0030170
Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.
1 Q9QZX7 (/IMP)
Pyridoxal phosphate binding GO:0030170
Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.
1 Q9QZX7 (/ISO)
Serine racemase activity GO:0030378
Catalysis of the synthesis of free D-serine from L-serine.
1 Q9QZX7 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 Q9QZX7 (/ISO)

There are 30 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
L-serine catabolic process GO:0006565
The chemical reactions and pathways resulting in the breakdown of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid.
155 P0AGF6 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA)
(145 more)
Threonine catabolic process GO:0006567
The chemical reactions and pathways resulting in the breakdown of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins.
155 P0AGF6 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA)
(145 more)
Threonine metabolic process GO:0006566
The chemical reactions and pathways involving threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins.
13 P37946 (/ISS) Q02145 (/ISS) Q02145 (/ISS) Q02145 (/ISS) Q02145 (/ISS) Q02145 (/ISS) Q49Z16 (/ISS) Q5HMF5 (/ISS) Q5HMF5 (/ISS) Q5HMF5 (/ISS)
(3 more)
L-serine metabolic process GO:0006563
The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid.
11 O59791 (/IDA) Q2PGG3 (/IDA) Q54HH2 (/IDA) Q76EQ0 (/IDA) Q7XSN8 (/IDA) Q7XSN8 (/IDA) Q7XSN8 (/IDA) Q7XSN8 (/IDA) Q7XSN8 (/IDA) Q9GZT4 (/IDA)
(1 more)
D-serine metabolic process GO:0070178
The chemical reactions and pathways involving D-serine, the D-enantiomer of serine, i.e. (2R)-2-amino-3-hydroxypropanoic acid.
9 O59791 (/IDA) Q2PGG3 (/IDA) Q76EQ0 (/IDA) Q7XSN8 (/IDA) Q7XSN8 (/IDA) Q7XSN8 (/IDA) Q7XSN8 (/IDA) Q7XSN8 (/IDA) Q9GZT4 (/IDA)
Cellular modified amino acid catabolic process GO:0042219
The chemical reactions and pathways resulting in the breakdown of compounds derived from amino acids, organic acids containing one or more amino substituents.
5 A4F2N8 (/IDA) A4F2N8 (/IDA) P36007 (/IDA) P36007 (/IDA) P36007 (/IDA)
Cellular modified amino acid catabolic process GO:0042219
The chemical reactions and pathways resulting in the breakdown of compounds derived from amino acids, organic acids containing one or more amino substituents.
3 P36007 (/IMP) P36007 (/IMP) P36007 (/IMP)
D-serine biosynthetic process GO:0070179
The chemical reactions and pathways resulting in the formation of D-serine, the D-enantiomer of serine, i.e. (2R)-2-amino-3-hydroxypropanoic acid. D-serine is often formed by racemization of L-serine.
3 Q54HH2 (/IDA) Q9GZT4 (/IDA) Q9QZX7 (/IDA)
Serine family amino acid metabolic process GO:0009069
The chemical reactions and pathways involving amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine.
2 Q2PGG3 (/IDA) Q9QZX7 (/IDA)
Isoleucine biosynthetic process GO:0009097
The chemical reactions and pathways resulting in the formation of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid.
2 A0A0F7RFZ2 (/ISS) A0A0F7RFZ2 (/ISS)
L-serine metabolic process GO:0006563
The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid.
1 Q9QZX7 (/ISO)
L-serine metabolic process GO:0006563
The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid.
1 A0JNI4 (/ISS)
L-serine biosynthetic process GO:0006564
The chemical reactions and pathways resulting in the formation of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid.
1 Q9GZT4 (/TAS)
L-serine catabolic process GO:0006565
The chemical reactions and pathways resulting in the breakdown of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid.
1 Q4QJ04 (/RCA)
Threonine catabolic process GO:0006567
The chemical reactions and pathways resulting in the breakdown of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins.
1 Q4QJ04 (/RCA)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
1 Q76EQ0 (/IEP)
Aging GO:0007568
A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
1 Q76EQ0 (/IEP)
Serine family amino acid metabolic process GO:0009069
The chemical reactions and pathways involving amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine.
1 Q9GZT4 (/ISS)
Response to organic cyclic compound GO:0014070
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
1 Q76EQ0 (/IEP)
Protein dehydration GO:0018249
The removal of a water group from a protein amino acid.
1 Q54HH2 (/IDA)
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
1 Q9GZT4 (/IEP)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 Q76EQ0 (/IEP)
Pyruvate biosynthetic process GO:0042866
The chemical reactions and pathways resulting in the formation of pyruvate, 2-oxopropanoate.
1 Q9GZT4 (/IDA)
Pyruvate biosynthetic process GO:0042866
The chemical reactions and pathways resulting in the formation of pyruvate, 2-oxopropanoate.
1 Q9QZX7 (/ISO)
Response to morphine GO:0043278
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a morphine stimulus. Morphine is an opioid alkaloid, isolated from opium, with a complex ring structure.
1 Q76EQ0 (/IEP)
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
1 Q9QZX7 (/IDA)
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
1 Q9GZT4 (/ISS)
D-serine metabolic process GO:0070178
The chemical reactions and pathways involving D-serine, the D-enantiomer of serine, i.e. (2R)-2-amino-3-hydroxypropanoic acid.
1 Q9QZX7 (/ISO)
D-serine metabolic process GO:0070178
The chemical reactions and pathways involving D-serine, the D-enantiomer of serine, i.e. (2R)-2-amino-3-hydroxypropanoic acid.
1 A0JNI4 (/ISS)
D-serine biosynthetic process GO:0070179
The chemical reactions and pathways resulting in the formation of D-serine, the D-enantiomer of serine, i.e. (2R)-2-amino-3-hydroxypropanoic acid. D-serine is often formed by racemization of L-serine.
1 Q9QZX7 (/ISO)

There are 11 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
155 P0AGF6 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA) P0AGF6 (/IDA)
(145 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q76EQ0 (/IDA) Q9GZT4 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q9QZX7 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q54HH2 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9GZT4 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q76EQ0 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q9QZX7 (/ISO)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 Q9GZT4 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 Q9QZX7 (/ISO)
Apical part of cell GO:0045177
The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.
1 Q76EQ0 (/IDA)
Apical part of cell GO:0045177
The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.
1 Q9QZX7 (/ISO)