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CATH Superfamily 3.40.50.10750

Isocitrate/Isopropylmalate dehydrogenase-like

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Isocitrate/Isopropylmalate dehydrogenase-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: NADP-dependent malic enzyme

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Malate dehydrogenase (decarboxylating) (NADP+) activity GO:0004473
Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+.
 18 P76558 (/IDA) P76558 (/IDA) P76558 (/IDA) P76558 (/IDA) P76558 (/IDA) P76558 (/IDA) P76558 (/IDA) P76558 (/IDA) P76558 (/IDA) P76558 (/IDA)
(8 more)
Malate dehydrogenase (decarboxylating) (NADP+) activity GO:0004473
Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+.
 18 P76558 (/IMP) P76558 (/IMP) P76558 (/IMP) P76558 (/IMP) P76558 (/IMP) P76558 (/IMP) P76558 (/IMP) P76558 (/IMP) P76558 (/IMP) P76558 (/IMP)
(8 more)
Manganese ion binding GO:0030145
Interacting selectively and non-covalently with manganese (Mn) ions.
 18 P76558 (/IDA) P76558 (/IDA) P76558 (/IDA) P76558 (/IDA) P76558 (/IDA) P76558 (/IDA) P76558 (/IDA) P76558 (/IDA) P76558 (/IDA) P76558 (/IDA)
(8 more)
Malic enzyme activity GO:0004470
Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate.
 7 Q2GHT3 (/ISS) Q2GLS5 (/ISS) Q2GLS5 (/ISS) Q2GLS5 (/ISS) Q2GLS5 (/ISS) Q2GLS5 (/ISS) Q5LPB6 (/ISS)
Malate dehydrogenase (decarboxylating) (NADP+) activity GO:0004473
Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+.
 1 Q5LWG9 (/ISS)

There are 1 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Malate metabolic process GO:0006108
The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle.
 8 Q2GHT3 (/ISS) Q2GLS5 (/ISS) Q2GLS5 (/ISS) Q2GLS5 (/ISS) Q2GLS5 (/ISS) Q2GLS5 (/ISS) Q5LPB6 (/ISS) Q5LWG9 (/ISS)

There are 1 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
 18 P76558 (/HDA) P76558 (/HDA) P76558 (/HDA) P76558 (/HDA) P76558 (/HDA) P76558 (/HDA) P76558 (/HDA) P76558 (/HDA) P76558 (/HDA) P76558 (/HDA)
(8 more)