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CATH Superfamily 3.40.50.10490

Glucose-6-phosphate isomerase like protein; domain 1

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Glucose-6-phosphate isomerase like protein; domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily EC Annotations

Note: the EC figure is not being displayed for this superfamily as there are more than 100 different EC terms.

There are 9 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Glucose-6-phosphate isomerase. [EC: 5.3.1.9]
D-glucose 6-phosphate = D-fructose 6-phosphate.
  • Also catalyzes the anomerization of D-glucose 6-phosphate.
 2911 A0A015NU85 A0A015NU85 A0A015RWN1 A0A015RWN1 A0A015UGF2 A0A015UGF2 A0A015V0V8 A0A015V0V8 A0A015VAW0 A0A015VAW0
(2901 more...)
Glutamine--fructose-6-phosphate transaminase (isomerizing). [EC: 2.6.1.16]
L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.
  • Although the overall reaction is that of a transferase, the mechanism involves the formation of ketimine between fructose 6-phosphate and a 6-amino group from a lysine residue at the active site, which is subsequently displaced by ammonia (transamidination).
  • Formerly EC 5.3.1.19.
 1090 A0A026V112 A0A026V112 A0A028AFW7 A0A028AFW7 A0A028DQZ2 A0A028DQZ2 A0A069XHW6 A0A069XHW6 A0A069ZTD4 A0A069ZTD4
(1080 more...)
D-sedoheptulose 7-phosphate isomerase. [EC: 5.3.1.28]
D-sedoheptulose 7-phosphate = D-glycero-D-manno-heptose 7-phosphate.
  • In Gram-negative bacteria the enzyme is involved in biosynthesis of ADP-L-glycero-beta-D-manno-heptose, which is utilized for assembly of the lipopolysaccharide inner core.
  • In Gram-positive bacteria the enzyme is involved in biosynthesis of GDP-D-glycero-alpha-D-manno-heptose, which is required for assembly of S-layer glycoprotein.
 814 A0A010S522 A0A023C8Q2 A0A023YRZ9 A0A025BW04 A0A026V342 A0A028A4Q9 A0A028E763 A0A029IBW4 A0A029J2A0 A0A059V5A4
(804 more...)
N-acetylmuramic acid 6-phosphate etherase. [EC: 4.2.1.126]
(R)-lactate + N-acetyl-D-glucosamine 6-phosphate = N-acetylmuramate 6-phosphate + H(2)O.
  • This enzyme, along with EC 2.7.1.170, is required for the utilization of anhydro-N-acetylmuramic acid in proteobacteria.
  • The substrate is either imported from the medium or derived from the bacterium's own cell wall murein during cell wall recycling.
  • Formerly EC 4.2.1.n1.
 532 A0A015QUS1 A0A015T8Q0 A0A015UTN6 A0A015VAW3 A0A015W5W4 A0A015WH35 A0A015XFA1 A0A015YQ43 A0A016CUV7 A0A016EDK7
(522 more...)
Arabinose-5-phosphate isomerase. [EC: 5.3.1.13]
D-arabinose 5-phosphate = D-ribulose 5-phosphate.
  • The enzyme is involved in the pathway for synthesis of 3-deoxy-D- manno-octulosonate (Kdo), a component of bacterial lipopolysaccharides and plant call walls.
 374 A0A023Z373 A0A025CGL0 A0A026V1T4 A0A028AJ19 A0A028ECH6 A0A029HK72 A0A029HQ60 A0A029IK74 A0A029ILE9 A0A069XJ62
(364 more...)
Mannose-6-phosphate isomerase. [EC: 5.3.1.8]
D-mannose 6-phosphate = D-fructose 6-phosphate.
    		 28 A0A0E3MAW2 A0A0E3MAW2 A0A0U3GH45 A0A0U3GH45 D0KUS8 D0KUS8 M1J2L3 M1J2L3 M1J9B6 M1J9B6
    (18 more...)
    Glucokinase. [EC: 2.7.1.2]
    ATP + D-glucose = ADP + D-glucose 6-phosphate.
    • A group of enzymes found in invertebrates and microorganisms highly specific for glucose.
    		 23 A0A069B3W2 A0A095PZJ8 A0A0E1SHG8 A0A0E1USY8 A0A0E1W7E7 A0A0F6GBQ0 A0A0F6LBG5 A0A0H3HHF9 A0A3B0EKX7 A0A3N9DD25
    (13 more...)
    6-phospho-3-hexuloisomerase. [EC: 5.3.1.27]
    D-arabino-hex-3-ulose 6-phosphate = D-fructose 6-phosphate.
    • This enzyme, along with EC 4.1.2.43, plays a key role in the ribulose-monophosphate cycle of formaldehyde fixation, which is present in many microorganisms that are capable of utilizing C1-compounds.
    • The hyperthermophilic and anaerobic archaeon Pyrococcus horikoshii OT3 constitutively produces a bifunctional enzyme that sequentially catalyzes the reactions of EC 4.1.2.43 and this enzyme.
    		 7 A0A164V7B4 A0A1B2B1V5 L8ACS8 P42404 Q58644 Q9LBW5 Q9S0X3
    Glucosamine-6-phosphate deaminase. [EC: 3.5.99.6]
    Alpha-D-glucosamine 6-phosphate + H(2)O = D-fructose 6-phosphate + NH(3).
    • Isomerization of the aldose-ketose type converts the -CH(-NH(2))-CH=O group of glucosamine 6-phosphate into -C(=NH)-CH(2)-OH, forming 2-deoxy-2-imino-D-arabino-hexitol which then hydrolyzes to yield fructose 6-phosphate and ammonia.
    • N-acetyl-D-glucosamine 6-phosphate, which is not broken down, activates the enzyme.
    • Formerly EC 5.3.1.10.
    		 2 A0KYQ7 A0KYQ7