The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"BRCT domain
".
FunFam 4: DNA ligase
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 5 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
18 |
P15042 (/IDA)
P15042 (/IDA)
P15042 (/IDA)
P15042 (/IDA)
P15042 (/IDA)
P15042 (/IDA)
P15042 (/IDA)
P15042 (/IDA)
P15042 (/IDA)
P15042 (/IDA)
(8 more) |
|
DNA ligase (NAD+) activity GO:0003911
Catalysis of the reaction: NAD+ + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + nicotinamide nucleotide + deoxyribonucleotide(n+m).
|
18 |
P15042 (/IDA)
P15042 (/IDA)
P15042 (/IDA)
P15042 (/IDA)
P15042 (/IDA)
P15042 (/IDA)
P15042 (/IDA)
P15042 (/IDA)
P15042 (/IDA)
P15042 (/IDA)
(8 more) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
18 |
P15042 (/IPI)
P15042 (/IPI)
P15042 (/IPI)
P15042 (/IPI)
P15042 (/IPI)
P15042 (/IPI)
P15042 (/IPI)
P15042 (/IPI)
P15042 (/IPI)
P15042 (/IPI)
(8 more) |
|
NAD+ binding GO:0070403
Interacting selectively and non-covalently with the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions.
|
18 |
P15042 (/IMP)
P15042 (/IMP)
P15042 (/IMP)
P15042 (/IMP)
P15042 (/IMP)
P15042 (/IMP)
P15042 (/IMP)
P15042 (/IMP)
P15042 (/IMP)
P15042 (/IMP)
(8 more) |
|
DNA ligase (NAD+) activity GO:0003911
Catalysis of the reaction: NAD+ + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + nicotinamide nucleotide + deoxyribonucleotide(n+m).
|
4 | Q9KTD1 (/ISS) Q9KTD1 (/ISS) Q9KTD1 (/ISS) Q9KTD1 (/ISS) |
There are 6 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
DNA ligation GO:0006266
The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase.
|
18 |
P15042 (/IDA)
P15042 (/IDA)
P15042 (/IDA)
P15042 (/IDA)
P15042 (/IDA)
P15042 (/IDA)
P15042 (/IDA)
P15042 (/IDA)
P15042 (/IDA)
P15042 (/IDA)
(8 more) |
|
Base-excision repair, DNA ligation GO:0006288
The ligation by DNA ligase of DNA strands. Ligation occurs after polymerase action to fill the gap left by the action of endonucleases during base-excision repair.
|
18 |
P15042 (/IDA)
P15042 (/IDA)
P15042 (/IDA)
P15042 (/IDA)
P15042 (/IDA)
P15042 (/IDA)
P15042 (/IDA)
P15042 (/IDA)
P15042 (/IDA)
P15042 (/IDA)
(8 more) |
|
DNA replication GO:0006260
The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
|
4 | Q9KTD1 (/ISS) Q9KTD1 (/ISS) Q9KTD1 (/ISS) Q9KTD1 (/ISS) |
|
DNA ligation GO:0006266
The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase.
|
4 | Q9KTD1 (/ISS) Q9KTD1 (/ISS) Q9KTD1 (/ISS) Q9KTD1 (/ISS) |
|
DNA repair GO:0006281
The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
|
4 | Q9KTD1 (/ISS) Q9KTD1 (/ISS) Q9KTD1 (/ISS) Q9KTD1 (/ISS) |
|
DNA recombination GO:0006310
Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
|
4 | Q9KTD1 (/ISS) Q9KTD1 (/ISS) Q9KTD1 (/ISS) Q9KTD1 (/ISS) |
There are 1 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
18 |
P15042 (/IDA)
P15042 (/IDA)
P15042 (/IDA)
P15042 (/IDA)
P15042 (/IDA)
P15042 (/IDA)
P15042 (/IDA)
P15042 (/IDA)
P15042 (/IDA)
P15042 (/IDA)
(8 more) |