The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
HAD superfamily/HAD-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 24: Phosphoglycolate phosphatase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 29 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Phosphatase activity GO:0016791
Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.
14 Q8IBV0 (/ISS) Q8IBV0 (/ISS) Q8IBV0 (/ISS) Q8IBV0 (/ISS) Q8IBV0 (/ISS) Q8IBV0 (/ISS) Q8IBV0 (/ISS) Q8IBV0 (/ISS) Q8IBV0 (/ISS) Q8IBV0 (/ISS)
(4 more)
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
7 A6NDG6 (/ISS) Q2T9S4 (/ISS) Q2T9S4 (/ISS) Q3ZBF9 (/ISS) Q8VD52 (/ISS) Q96GD0 (/ISS) Q96GD0 (/ISS)
Phosphoglycolate phosphatase activity GO:0008967
Catalysis of the reaction: 2-phosphoglycolate + H(2)O = glycolate + phosphate.
7 A6NDG6 (/IDA) G8BCM7 (/IDA) P19881 (/IDA) P19881 (/IDA) P19881 (/IDA) Q59WC5 (/IDA) Q59WC5 (/IDA)
Phosphatase activity GO:0016791
Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.
7 O76864 (/IDA) P19881 (/IDA) P19881 (/IDA) P19881 (/IDA) Q00472 (/IDA) Q9VYT0 (/IDA) Q9W4W5 (/IDA)
Phosphoprotein phosphatase activity GO:0004721
Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity.
6 P19881 (/IDA) P19881 (/IDA) P19881 (/IDA) Q3ZBF9 (/IDA) Q96GD0 (/IDA) Q96GD0 (/IDA)
Phosphoprotein phosphatase activity GO:0004721
Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity.
5 M9PJJ5 (/ISS) O76864 (/ISS) P60487 (/ISS) Q8VD52 (/ISS) Q9W4W5 (/ISS)
Pyridoxal phosphatase activity GO:0033883
Catalysis of the reaction: pyridoxal 5'-phosphate + H2O = pyridoxal + phosphate.
4 Q3ZBF9 (/ISS) Q8VD52 (/ISS) Q96GD0 (/ISS) Q96GD0 (/ISS)
Alkaline phosphatase activity GO:0004035
Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum.
3 P19881 (/IDA) P19881 (/IDA) P19881 (/IDA)
Protein tyrosine phosphatase activity GO:0004725
Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
3 A6NDG6 (/ISS) Q2T9S4 (/ISS) Q2T9S4 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 P60487 (/IPI) Q96GD0 (/IPI) Q96GD0 (/IPI)
Glycerol-3-phosphatase activity GO:0043136
Catalysis of the reaction: glycerol 3-phosphate + H2O = glycerol + phosphate.
3 Q2T9S4 (/ISS) Q2T9S4 (/ISS) Q5F4B1 (/ISS)
Nucleotide phosphatase activity, acting on free nucleotides GO:0098519
Catalysis of the reaction: nucleotide + H2O = nucleotide + phosphate.
3 A6NDG6 (/ISS) Q2T9S4 (/ISS) Q2T9S4 (/ISS)
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
2 P60487 (/IDA) Q8CHP8 (/IDA)
Phosphoglycolate phosphatase activity GO:0008967
Catalysis of the reaction: 2-phosphoglycolate + H(2)O = glycolate + phosphate.
2 Q2T9S4 (/ISS) Q2T9S4 (/ISS)
Heat shock protein binding GO:0031072
Interacting selectively and non-covalently with a heat shock protein, any protein synthesized or activated in response to heat shock.
2 Q96GD0 (/IDA) Q96GD0 (/IDA)
Glycerol-3-phosphatase activity GO:0043136
Catalysis of the reaction: glycerol 3-phosphate + H2O = glycerol + phosphate.
2 A6NDG6 (/IDA) Q8CHP8 (/IDA)
Alkaline phosphatase activity GO:0004035
Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum.
1 Q00472 (/ISO)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
1 Q8GWU0 (/ISS)
Phosphoprotein phosphatase activity GO:0004721
Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity.
1 P60487 (/ISO)
Protein tyrosine phosphatase activity GO:0004725
Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
1 Q8CHP8 (/IDA)
Phosphoglycolate phosphatase activity GO:0008967
Catalysis of the reaction: 2-phosphoglycolate + H(2)O = glycolate + phosphate.
1 Q8CHP8 (/ISO)
Growth factor binding GO:0019838
Interacting selectively and non-covalently with any growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate.
1 Q8VD52 (/IPI)
Growth factor binding GO:0019838
Interacting selectively and non-covalently with any growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate.
1 P60487 (/ISO)
Heat shock protein binding GO:0031072
Interacting selectively and non-covalently with a heat shock protein, any protein synthesized or activated in response to heat shock.
1 P60487 (/ISO)
Pyridoxal phosphatase activity GO:0033883
Catalysis of the reaction: pyridoxal 5'-phosphate + H2O = pyridoxal + phosphate.
1 P60487 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 P60487 (/IPI)
Glycerol-3-phosphatase activity GO:0043136
Catalysis of the reaction: glycerol 3-phosphate + H2O = glycerol + phosphate.
1 D3ZDK7 (/IMP)
Glycerol-3-phosphatase activity GO:0043136
Catalysis of the reaction: glycerol 3-phosphate + H2O = glycerol + phosphate.
1 Q8CHP8 (/ISO)
Nucleotide phosphatase activity, acting on free nucleotides GO:0098519
Catalysis of the reaction: nucleotide + H2O = nucleotide + phosphate.
1 Q8CHP8 (/IDA)

There are 36 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein dephosphorylation GO:0006470
The process of removing one or more phosphoric residues from a protein.
6 P19881 (/IDA) P19881 (/IDA) P19881 (/IDA) Q3ZBF9 (/IDA) Q96GD0 (/IDA) Q96GD0 (/IDA)
Protein dephosphorylation GO:0006470
The process of removing one or more phosphoric residues from a protein.
5 M9PJJ5 (/ISS) O76864 (/ISS) P60487 (/ISS) Q8VD52 (/ISS) Q9W4W5 (/ISS)
Pyridoxal phosphate catabolic process GO:0032361
The chemical reactions and pathways resulting in the breakdown of pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6.
4 Q3ZBF9 (/ISS) Q8VD52 (/ISS) Q96GD0 (/ISS) Q96GD0 (/ISS)
Negative regulation of gluconeogenesis GO:0045721
Any process that stops, prevents, or reduces the frequency, rate or extent of gluconeogenesis.
4 Q2T9S4 (/ISS) Q2T9S4 (/ISS) Q5F4B1 (/ISS) Q8CHP8 (/ISS)
Glycerol biosynthetic process GO:0006114
The chemical reactions and pathways resulting in the formation of glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids.
3 A6NDG6 (/IDA) D3ZDK7 (/IDA) Q8CHP8 (/IDA)
Glycerol biosynthetic process GO:0006114
The chemical reactions and pathways resulting in the formation of glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids.
3 Q2T9S4 (/ISS) Q2T9S4 (/ISS) Q5F4B1 (/ISS)
Glycerophospholipid metabolic process GO:0006650
The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue.
3 Q2T9S4 (/ISS) Q2T9S4 (/ISS) Q5F4B1 (/ISS)
Regulation of mitotic nuclear division GO:0007088
Any process that modulates the frequency, rate or extent of mitosis.
3 P60487 (/ISS) Q3ZBF9 (/ISS) Q8VD52 (/ISS)
Dephosphorylation GO:0016311
The process of removing one or more phosphoric (ester or anhydride) residues from a molecule.
3 A6NDG6 (/ISS) Q2T9S4 (/ISS) Q2T9S4 (/ISS)
Positive regulation of actin filament depolymerization GO:0030836
Any process that activates or increases the frequency, rate or extent of actin depolymerization.
3 P60487 (/ISS) Q3ZBF9 (/ISS) Q8VD52 (/ISS)
Regulation of cytokinesis GO:0032465
Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells.
3 P60487 (/ISS) Q3ZBF9 (/ISS) Q8VD52 (/ISS)
Peptidyl-tyrosine dephosphorylation GO:0035335
The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine.
3 A6NDG6 (/ISS) Q2T9S4 (/ISS) Q2T9S4 (/ISS)
Phosphorylated carbohydrate dephosphorylation GO:0046838
The process of removing a phosphate group from a phosphorylated carbohydrate, any organic compound based on the general formula Cx(H2O)y with a phosphate group attached to it.
3 P19881 (/IDA) P19881 (/IDA) P19881 (/IDA)
Glycerophospholipid metabolic process GO:0006650
The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue.
2 A6NDG6 (/IDA) Q8CHP8 (/IDA)
Regulation of mitotic nuclear division GO:0007088
Any process that modulates the frequency, rate or extent of mitosis.
2 Q96GD0 (/IMP) Q96GD0 (/IMP)
Dephosphorylation GO:0016311
The process of removing one or more phosphoric (ester or anhydride) residues from a molecule.
2 Q8CHP8 (/IDA) Q9VYT0 (/IDA)
Positive regulation of actin filament depolymerization GO:0030836
Any process that activates or increases the frequency, rate or extent of actin depolymerization.
2 Q96GD0 (/IMP) Q96GD0 (/IMP)
Actin rod assembly GO:0031247
The assembly of actin rods, a cellular structure consisting of parallel, hexagonally arranged actin tubules.
2 Q96GD0 (/IDA) Q96GD0 (/IDA)
Actin rod assembly GO:0031247
The assembly of actin rods, a cellular structure consisting of parallel, hexagonally arranged actin tubules.
2 Q96GD0 (/IMP) Q96GD0 (/IMP)
Regulation of cytokinesis GO:0032465
Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells.
2 Q96GD0 (/IMP) Q96GD0 (/IMP)
Phenotypic switching GO:0036166
A reversible switch of a cell from one cell type or form to another, at a frequency above the expected frequency for somatic mutations. Phenotypic switching involves changes in cell morphology and altered gene expression patterns. For example, Candida albicans switches from white cells to opaque cells for sexual mating. Phenotypic switching also occurs in multicellular organisms; smooth muscle cells (SMCs) exhibit phenotypic transitions to allow rapid adaption to fluctuating environmental cues.
2 Q59WC5 (/IMP) Q59WC5 (/IMP)
Negative regulation of gluconeogenesis GO:0045721
Any process that stops, prevents, or reduces the frequency, rate or extent of gluconeogenesis.
2 A6NDG6 (/IMP) D3ZDK7 (/IMP)
Cellular response to ATP GO:0071318
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus.
2 Q96GD0 (/IDA) Q96GD0 (/IDA)
Glycerol biosynthetic process GO:0006114
The chemical reactions and pathways resulting in the formation of glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids.
1 Q8CHP8 (/ISO)
Protein dephosphorylation GO:0006470
The process of removing one or more phosphoric residues from a protein.
1 P60487 (/ISO)
Glycerophospholipid metabolic process GO:0006650
The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue.
1 D3ZDK7 (/IMP)
Glycerophospholipid metabolic process GO:0006650
The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue.
1 Q8CHP8 (/ISO)
Regulation of mitotic nuclear division GO:0007088
Any process that modulates the frequency, rate or extent of mitosis.
1 P60487 (/ISO)
Positive regulation of actin filament depolymerization GO:0030836
Any process that activates or increases the frequency, rate or extent of actin depolymerization.
1 P60487 (/ISO)
Actin rod assembly GO:0031247
The assembly of actin rods, a cellular structure consisting of parallel, hexagonally arranged actin tubules.
1 P60487 (/ISO)
Pyridoxal phosphate catabolic process GO:0032361
The chemical reactions and pathways resulting in the breakdown of pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6.
1 P60487 (/IDA)
Regulation of cytokinesis GO:0032465
Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells.
1 P60487 (/ISO)
Peptidyl-tyrosine dephosphorylation GO:0035335
The removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine.
1 Q8CHP8 (/IDA)
Negative regulation of gluconeogenesis GO:0045721
Any process that stops, prevents, or reduces the frequency, rate or extent of gluconeogenesis.
1 Q8CHP8 (/ISO)
Cellular response to ATP GO:0071318
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus.
1 P60487 (/ISO)
Cellular detoxification GO:1990748
Any process carried out at the cellular level that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance.
1 Q00472 (/NAS)

There are 9 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
17 Q3ZBF9 (/IDA) Q8IBV0 (/IDA) Q8IBV0 (/IDA) Q8IBV0 (/IDA) Q8IBV0 (/IDA) Q8IBV0 (/IDA) Q8IBV0 (/IDA) Q8IBV0 (/IDA) Q8IBV0 (/IDA) Q8IBV0 (/IDA)
(7 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
5 M9PJJ5 (/ISS) O76864 (/ISS) P60487 (/ISS) Q8VD52 (/ISS) Q9W4W5 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
4 P19881 (/HDA) P19881 (/HDA) P19881 (/HDA) Q00472 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 P19881 (/HDA) P19881 (/HDA) P19881 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q00472 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P60487 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 D3ZDK7 (/TAS)
Cell-cell junction GO:0005911
A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.
1 P60487 (/IDA)
Chloroplast GO:0009507
A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
1 Q8GWU0 (/IDA)