The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
HAD superfamily/HAD-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 14: Phospholipid-transporting ATPase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
ATPase-coupled intramembrane lipid transporter activity GO:0140326
Catalysis of the movement of lipids from one membrane leaflet to the other, using energy from the hydrolysis of ATP. This includes flippases and floppases.
5 A0A0B4K638 (/ISS) A0A0B4K756 (/ISS) A0A0B4LH21 (/ISS) A0A0B4LH79 (/ISS) Q9VGD4 (/ISS)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
2 Q9SLK6 (/IDA) Q9SLK6 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 P98199 (/IPI)
Phosphatidylethanolamine flippase activity GO:0090555
Catalysis of the movement of phosphatidylethanolamine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP.
1 A3FIN4 (/IMP)

There are 11 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of protein localization GO:0032880
Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.
5 A0A0B4K638 (/IMP) A0A0B4K756 (/IMP) A0A0B4LH21 (/IMP) A0A0B4LH79 (/IMP) Q9VGD4 (/IMP)
Phospholipid translocation GO:0045332
The movement of a phospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet.
5 A0A0B4K638 (/ISS) A0A0B4K756 (/ISS) A0A0B4LH21 (/ISS) A0A0B4LH79 (/ISS) Q9VGD4 (/ISS)
Detection of chemical stimulus involved in sensory perception of smell GO:0050911
The series of events involved in the perception of smell in which an olfactory chemical stimulus is received and converted into a molecular signal.
5 A0A0B4K638 (/IMP) A0A0B4K756 (/IMP) A0A0B4LH21 (/IMP) A0A0B4LH79 (/IMP) Q9VGD4 (/IMP)
Pollen tube growth GO:0009860
Growth of pollen via tip extension of the intine wall.
3 Q9LVK9 (/IGI) Q9SLK6 (/IGI) Q9SLK6 (/IGI)
Ion transmembrane transport GO:0034220
A process in which an ion is transported across a membrane.
3 P98198 (/TAS) P98198 (/TAS) P98198 (/TAS)
Regulation of membrane lipid metabolic process GO:1905038
Any process that modulates the frequency, rate or extent of membrane lipid metabolic process.
3 Q9LVK9 (/IGI) Q9SLK6 (/IGI) Q9SLK6 (/IGI)
Heat acclimation GO:0010286
Any process that increases heat tolerance of an organism in response to high temperatures.
2 Q9SLK6 (/IMP) Q9SLK6 (/IMP)
Sterol metabolic process GO:0016125
The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
2 Q7YXV5 (/IMP) Q9TXV2 (/IMP)
Golgi organization GO:0007030
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus.
1 A3FIN4 (/IMP)
Phospholipid transport GO:0015914
The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester.
1 A3FIN4 (/IMP)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
1 Q8TF62 (/TAS)

There are 14 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
11 F4IE35 (/IDA) P98198 (/IDA) P98198 (/IDA) P98198 (/IDA) Q8TF62 (/IDA) Q9LI83 (/IDA) Q9LNQ4 (/IDA) Q9LNQ4 (/IDA) Q9SAF5 (/IDA) Q9SLK6 (/IDA)
(1 more)
Cilium GO:0005929
A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
5 A0A0B4K638 (/IDA) A0A0B4K756 (/IDA) A0A0B4LH21 (/IDA) A0A0B4LH79 (/IDA) Q9VGD4 (/IDA)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
5 A0A0B4K638 (/ISM) A0A0B4K756 (/ISM) A0A0B4LH21 (/ISM) A0A0B4LH79 (/ISM) Q9VGD4 (/ISM)
Sensory dendrite GO:0071683
A dendrite that is found on a sensory neuron, and directly transduces a sensory signal from the sensory neuron to another neuron.
5 A0A0B4K638 (/IDA) A0A0B4K756 (/IDA) A0A0B4LH21 (/IDA) A0A0B4LH79 (/IDA) Q9VGD4 (/IDA)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
4 P98198 (/IDA) P98198 (/IDA) P98198 (/IDA) Q8TF62 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 P98198 (/TAS) P98198 (/TAS) P98198 (/TAS) Q8TF62 (/TAS)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
3 A1L3S5 (/ISO) A2ANX3 (/ISO) P98199 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 A1L3S5 (/ISO) A2ANX3 (/ISO) P98199 (/ISO)
Endomembrane system GO:0012505
A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
2 Q9SLK6 (/IDA) Q9SLK6 (/IDA)
Acrosomal vesicle GO:0001669
A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome.
1 A3FIN4 (/IDA)
Chloroplast envelope GO:0009941
The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space.
1 F4IE35 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 A3FIN4 (/IDA)
Specific granule membrane GO:0035579
The lipid bilayer surrounding a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.
1 Q8TF62 (/TAS)
Tertiary granule membrane GO:0070821
The lipid bilayer surrounding a tertiary granule.
1 Q8TF62 (/TAS)