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CATH Superfamily 3.40.430.10

Dihydrofolate Reductase, subunit A

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Dihydrofolate Reductase, subunit A
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Dihydrofolate reductase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Dihydrofolate reductase activity GO:0004146
Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+.
 89 P0ABQ4 (/IDA) P0ABQ4 (/IDA) P0ABQ4 (/IDA) P0ABQ4 (/IDA) P0ABQ4 (/IDA) P0ABQ4 (/IDA) P0ABQ4 (/IDA) P0ABQ4 (/IDA) P0ABQ4 (/IDA) P0ABQ4 (/IDA)
(79 more)
NADP+ binding GO:0070401
Interacting selectively and non-covalently with the oxidized form, NADP+, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.
 89 P0ABQ4 (/IDA) P0ABQ4 (/IDA) P0ABQ4 (/IDA) P0ABQ4 (/IDA) P0ABQ4 (/IDA) P0ABQ4 (/IDA) P0ABQ4 (/IDA) P0ABQ4 (/IDA) P0ABQ4 (/IDA) P0ABQ4 (/IDA)
(79 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
 83 P0ABQ4 (/IPI) P0ABQ4 (/IPI) P0ABQ4 (/IPI) P0ABQ4 (/IPI) P0ABQ4 (/IPI) P0ABQ4 (/IPI) P0ABQ4 (/IPI) P0ABQ4 (/IPI) P0ABQ4 (/IPI) P0ABQ4 (/IPI)
(73 more)
Folic acid binding GO:0005542
Interacting selectively and non-covalently with folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.
 83 P0ABQ4 (/IDA) P0ABQ4 (/IDA) P0ABQ4 (/IDA) P0ABQ4 (/IDA) P0ABQ4 (/IDA) P0ABQ4 (/IDA) P0ABQ4 (/IDA) P0ABQ4 (/IDA) P0ABQ4 (/IDA) P0ABQ4 (/IDA)
(73 more)
Folic acid binding GO:0005542
Interacting selectively and non-covalently with folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.
 83 P0ABQ4 (/IMP) P0ABQ4 (/IMP) P0ABQ4 (/IMP) P0ABQ4 (/IMP) P0ABQ4 (/IMP) P0ABQ4 (/IMP) P0ABQ4 (/IMP) P0ABQ4 (/IMP) P0ABQ4 (/IMP) P0ABQ4 (/IMP)
(73 more)
Methotrexate binding GO:0051870
Interacting selectively and non-covalently with methotrexate, an antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofolate reductase and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.
 83 P0ABQ4 (/IMP) P0ABQ4 (/IMP) P0ABQ4 (/IMP) P0ABQ4 (/IMP) P0ABQ4 (/IMP) P0ABQ4 (/IMP) P0ABQ4 (/IMP) P0ABQ4 (/IMP) P0ABQ4 (/IMP) P0ABQ4 (/IMP)
(73 more)
Dihydrofolic acid binding GO:0051871
Interacting selectively and non-covalently with dihydrofolic acid, a folic acid in which the bicyclic pteridine structure is in the dihydro, partially reduced form; they are intermediates in folate metabolism and are reduced to their tetrahydro, reduced forms.
 83 P0ABQ4 (/IDA) P0ABQ4 (/IDA) P0ABQ4 (/IDA) P0ABQ4 (/IDA) P0ABQ4 (/IDA) P0ABQ4 (/IDA) P0ABQ4 (/IDA) P0ABQ4 (/IDA) P0ABQ4 (/IDA) P0ABQ4 (/IDA)
(73 more)
NADP+ binding GO:0070401
Interacting selectively and non-covalently with the oxidized form, NADP+, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.
 83 P0ABQ4 (/IMP) P0ABQ4 (/IMP) P0ABQ4 (/IMP) P0ABQ4 (/IMP) P0ABQ4 (/IMP) P0ABQ4 (/IMP) P0ABQ4 (/IMP) P0ABQ4 (/IMP) P0ABQ4 (/IMP) P0ABQ4 (/IMP)
(73 more)
NADPH binding GO:0070402
Interacting selectively and non-covalently with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.
 83 P0ABQ4 (/IDA) P0ABQ4 (/IDA) P0ABQ4 (/IDA) P0ABQ4 (/IDA) P0ABQ4 (/IDA) P0ABQ4 (/IDA) P0ABQ4 (/IDA) P0ABQ4 (/IDA) P0ABQ4 (/IDA) P0ABQ4 (/IDA)
(73 more)
NADPH binding GO:0070402
Interacting selectively and non-covalently with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.
 83 P0ABQ4 (/IMP) P0ABQ4 (/IMP) P0ABQ4 (/IMP) P0ABQ4 (/IMP) P0ABQ4 (/IMP) P0ABQ4 (/IMP) P0ABQ4 (/IMP) P0ABQ4 (/IMP) P0ABQ4 (/IMP) P0ABQ4 (/IMP)
(73 more)
Dihydrofolate reductase activity GO:0004146
Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+.
 7 Q9KUS5 (/ISS) Q9KUS5 (/ISS) Q9KUS5 (/ISS) Q9KUS5 (/ISS) Q9KUS5 (/ISS) Q9KUS5 (/ISS) Q9KUS5 (/ISS)
Dihydrofolate reductase activity GO:0004146
Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+.
 6 S5Y0G6 (/ISA) S5Y0G6 (/ISA) S5Y0G6 (/ISA) S5Y0G6 (/ISA) S5Y0G6 (/ISA) S5Y0G6 (/ISA)

There are 4 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
 83 P0ABQ4 (/IDA) P0ABQ4 (/IDA) P0ABQ4 (/IDA) P0ABQ4 (/IDA) P0ABQ4 (/IDA) P0ABQ4 (/IDA) P0ABQ4 (/IDA) P0ABQ4 (/IDA) P0ABQ4 (/IDA) P0ABQ4 (/IDA)
(73 more)
Folic acid-containing compound metabolic process GO:0006760
The chemical reactions and pathways involving a folic acid-containing compound, i.e. any of a group of heterocyclic compounds based on the pteroic acid skeleton conjugated with one or more L-glutamic acid or L-glutamate units.
 7 Q9KUS5 (/ISS) Q9KUS5 (/ISS) Q9KUS5 (/ISS) Q9KUS5 (/ISS) Q9KUS5 (/ISS) Q9KUS5 (/ISS) Q9KUS5 (/ISS)
One-carbon metabolic process GO:0006730
The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states.
 6 P9WNX1 (/IDA) P9WNX1 (/IDA) P9WNX1 (/IDA) P9WNX1 (/IDA) P9WNX1 (/IDA) P9WNX1 (/IDA)
Tetrahydrofolate biosynthetic process GO:0046654
The chemical reactions and pathways resulting in the formation of tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group.
 6 P9WNX1 (/IDA) P9WNX1 (/IDA) P9WNX1 (/IDA) P9WNX1 (/IDA) P9WNX1 (/IDA) P9WNX1 (/IDA)

There are 1 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
 83 P0ABQ4 (/IDA) P0ABQ4 (/IDA) P0ABQ4 (/IDA) P0ABQ4 (/IDA) P0ABQ4 (/IDA) P0ABQ4 (/IDA) P0ABQ4 (/IDA) P0ABQ4 (/IDA) P0ABQ4 (/IDA) P0ABQ4 (/IDA)
(73 more)