The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

Aldehyde Dehydrogenase; Chain A, domain 2

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 2: Methylmalonate-semialdehyde dehydrogenase (Acylati...

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Methylmalonate-semialdehyde dehydrogenase (CoA acylating). [EC:]
2-methyl-3-oxopropanoate + CoA + H(2)O + NAD(+) = propanoyl-CoA + HCO(3)(-) + NADH.
  • Also converts 3-oxopropanoate into acetyl-CoA.
  • The reaction occurs in two steps with the decarboxylation process preceding CoA-binding.
  • Bicarbonate rather than CO(2) is released as a final product.
2041 A0A024R6G4 A0A024R6G4 A0A063XH35 A0A063XH35 A0A063XH35 A0A063XH35 A0A063XH35 A0A080VFN0 A0A080VFN0 A0A080VFN0
(2031 more...)
Malonate-semialdehyde dehydrogenase (acetylating). [EC:]
3-oxopropanoate + CoA + NAD(P)(+) = acetyl-CoA + CO(2) + NAD(P)H.
    37 A0A024R6G4 A0A024R6G4 A0A182HSV9 A0A182HSV9 A0A182HSV9 A0A182HSV9 A0A182HSV9 A0A182LEZ0 A0A182LEZ0 A0A182LEZ0
    (27 more...)