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CATH Superfamily 3.40.309.10

Aldehyde Dehydrogenase; Chain A, domain 2

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Aldehyde Dehydrogenase; Chain A, domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 17: Aldehyde dehydrogenase B

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Aldehyde dehydrogenase (NAD(+)). [EC: 1.2.1.3]
An aldehyde + NAD(+) + H(2)O = a carboxylate + NADH.
  • Wide specificity, including oxidation of D-glucuronolactone to D-glucarate.
  • Formerly EC 1.1.1.70.
 90 A0A045HU59 A0A045HU59 A0A045HU59 A0A045HU59 A0A045HU59 A0A045HU59 A0A045HU59 A0A045HU59 A0A045HU59 A0A0H3L9K4
(80 more...)
Fluoroacetaldehyde dehydrogenase. [EC: 1.2.1.69]
Fluoroacetaldehyde + NAD(+) + H(2)O = fluoroacetate + NADH.
  • The enzyme from Streptomyces cattleya has a high affinity for fluoroacetate and glycolaldehyde but not for acetaldehyde.
 1 F8JX40
Long-chain-aldehyde dehydrogenase. [EC: 1.2.1.48]
A long-chain aldehyde + NAD(+) + H(2)O = a long-chain acid anion + NADH.
  • The best substrate is dodecylaldehyde.
 1 Q9FDS1