The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Aldehyde Dehydrogenase; Chain A, domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Mitochondrial aldehyde dehydrogenase 2

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Aldehyde dehydrogenase (NAD(P)(+)). [EC: 1.2.1.5]
An aldehyde + NAD(P)(+) + H(2)O = a carboxylate + NAD(P)H.
    100 A0A0L8VGX9 A0A0L8VGX9 A0A0L8VGX9 A0A0L8VGX9 A0A0L8VGX9 A0A0L8VGX9 A0A0L8VRP0 A0A0L8VRP0 A0A0L8VRP0 A0A0L8VRP0
    (90 more...)
    Aldehyde dehydrogenase (NAD(+)). [EC: 1.2.1.3]
    An aldehyde + NAD(+) + H(2)O = a carboxylate + NADH.
    • Wide specificity, including oxidation of D-glucuronolactone to D-glucarate.
    • Formerly EC 1.1.1.70.
    40 A0A2J8XKY0 A0A2J8XKY0 A0A2J8XKY0 A0A384NPN7 A0A384NPN7 A0A384NPN7 A0A480JH02 A0A480JH02 B2RTL5 B2RTL5
    (30 more...)
    Retinal dehydrogenase. [EC: 1.2.1.36]
    Retinal + NAD(+) + H(2)O = retinoate + NADH.
    • Acts on both the 11-trans- and 13-cis-forms of retinal.
    38 A0A024RC95 A0A024RC95 A0A1U7QDB4 A0A1U7QDB4 A0A226PKF6 A0A226PKF6 G2HJM2 G2HJM2 G2HJM2 O93344
    (28 more...)