The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Glutaredoxin
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 75: Glutathione S-transferase omega-1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 13 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Oxidoreductase activity GO:0016491
Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
8 O09131 (/ISS) Q6AXV9 (/ISS) Q6AXV9 (/ISS) Q8K2Q2 (/ISS) Q9N1F5 (/ISS) Q9N1F5 (/ISS) Q9Z339 (/ISS) Q9Z339 (/ISS)
Glutathione dehydrogenase (ascorbate) activity GO:0045174
Catalysis of the reaction: dehydroascorbate + 2 glutathione = L-ascorbate + glutathione disulfide.
6 O09131 (/ISS) Q6AXV9 (/ISS) Q6AXV9 (/ISS) Q8K2Q2 (/ISS) Q9N1F5 (/ISS) Q9N1F5 (/ISS)
Glutathione transferase activity GO:0004364
Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group.
5 O09131 (/ISS) Q9N1F5 (/ISS) Q9N1F5 (/ISS) Q9Z339 (/ISS) Q9Z339 (/ISS)
Glutathione dehydrogenase (ascorbate) activity GO:0045174
Catalysis of the reaction: dehydroascorbate + 2 glutathione = L-ascorbate + glutathione disulfide.
5 P78417 (/IDA) P78417 (/IDA) Q9H4Y5 (/IDA) Q9Z339 (/IDA) Q9Z339 (/IDA)
Glutathione transferase activity GO:0004364
Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group.
4 F1QBZ6 (/IDA) P78417 (/IDA) P78417 (/IDA) Q5U3M8 (/IDA)
Antioxidant activity GO:0016209
Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage.
4 C1BFM5 (/IDA) C1BFQ9 (/IDA) C1BG28 (/IDA) C1BHF6 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 P78417 (/IPI) P78417 (/IPI) Q9H4Y5 (/IPI)
Oxidoreductase activity GO:0016491
Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
3 P78417 (/IDA) P78417 (/IDA) Q9H4Y5 (/IDA)
Oxidoreductase activity GO:0016491
Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
2 O09131 (/ISO) Q8K2Q2 (/ISO)
Glutathione dehydrogenase (ascorbate) activity GO:0045174
Catalysis of the reaction: dehydroascorbate + 2 glutathione = L-ascorbate + glutathione disulfide.
2 O09131 (/ISO) Q8K2Q2 (/ISO)
Glutathione transferase activity GO:0004364
Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group.
1 O09131 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q9H4Y5 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q8K2Q2 (/ISO)

There are 29 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
L-ascorbic acid metabolic process GO:0019852
The chemical reactions and pathways involving L-ascorbic acid, (2R)-2-
8 O09131 (/ISS) Q6AXV9 (/ISS) Q6AXV9 (/ISS) Q8K2Q2 (/ISS) Q9N1F5 (/ISS) Q9N1F5 (/ISS) Q9Z339 (/ISS) Q9Z339 (/ISS)
Cellular response to arsenic-containing substance GO:0071243
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides.
8 O09131 (/ISS) Q6AXV9 (/ISS) Q6AXV9 (/ISS) Q8K2Q2 (/ISS) Q9N1F5 (/ISS) Q9N1F5 (/ISS) Q9Z339 (/ISS) Q9Z339 (/ISS)
Xenobiotic catabolic process GO:0042178
The chemical reactions and pathways resulting in the breakdown of a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide.
5 O09131 (/ISS) Q9N1F5 (/ISS) Q9N1F5 (/ISS) Q9Z339 (/ISS) Q9Z339 (/ISS)
Xenobiotic metabolic process GO:0006805
The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide.
3 Q6AXV9 (/ISS) Q6AXV9 (/ISS) Q8K2Q2 (/ISS)
L-ascorbic acid metabolic process GO:0019852
The chemical reactions and pathways involving L-ascorbic acid, (2R)-2-
3 P78417 (/IDA) P78417 (/IDA) Q9H4Y5 (/IDA)
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
3 Q6AXV9 (/ISS) Q6AXV9 (/ISS) Q8K2Q2 (/ISS)
Cellular response to arsenic-containing substance GO:0071243
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides.
3 P78417 (/IDA) P78417 (/IDA) Q9H4Y5 (/IDA)
Glutathione derivative biosynthetic process GO:1901687
The chemical reactions and pathways resulting in the formation of glutathione derivative.
3 P78417 (/TAS) P78417 (/TAS) Q9H4Y5 (/TAS)
Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880
Any process that modulates the rate, frequency or extent of release of sequestered calcium ion into cytosol by the sarcoplasmic reticulum, the process in which the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels.
2 P78417 (/IDA) P78417 (/IDA)
Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0010881
Any process that modulates the frequency, rate or extent of cardiac muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction.
2 P78417 (/IC) P78417 (/IC)
Positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion GO:0014810
Any process that activates, maintains or increases the frequency, rate or extent of skeletal muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction.
2 P78417 (/IC) P78417 (/IC)
L-ascorbic acid metabolic process GO:0019852
The chemical reactions and pathways involving L-ascorbic acid, (2R)-2-
2 O09131 (/ISO) Q8K2Q2 (/ISO)
L-ascorbic acid biosynthetic process GO:0019853
The chemical reactions and pathways resulting in the formation of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-
2 Q9Z339 (/IMP) Q9Z339 (/IMP)
Methylation GO:0032259
The process in which a methyl group is covalently attached to a molecule.
2 P78417 (/TAS) P78417 (/TAS)
Interleukin-12-mediated signaling pathway GO:0035722
A series of molecular signals initiated by the binding of interleukin-12 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 P78417 (/TAS) P78417 (/TAS)
Xenobiotic catabolic process GO:0042178
The chemical reactions and pathways resulting in the breakdown of a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide.
2 P78417 (/IDA) P78417 (/IDA)
Negative regulation of ryanodine-sensitive calcium-release channel activity GO:0060315
Any process that decreases the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts.
2 P78417 (/IDA) P78417 (/IDA)
Positive regulation of ryanodine-sensitive calcium-release channel activity GO:0060316
Any process that increases the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts.
2 P78417 (/IDA) P78417 (/IDA)
Cellular response to arsenic-containing substance GO:0071243
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides.
2 O09131 (/ISO) Q8K2Q2 (/ISO)
Xenobiotic metabolic process GO:0006805
The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide.
1 Q9H4Y5 (/IDA)
Xenobiotic metabolic process GO:0006805
The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide.
1 Q8K2Q2 (/ISO)
Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880
Any process that modulates the rate, frequency or extent of release of sequestered calcium ion into cytosol by the sarcoplasmic reticulum, the process in which the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels.
1 O09131 (/ISO)
L-ascorbic acid metabolic process GO:0019852
The chemical reactions and pathways involving L-ascorbic acid, (2R)-2-
1 Q9H4Y5 (/TAS)
L-ascorbic acid biosynthetic process GO:0019853
The chemical reactions and pathways resulting in the formation of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-
1 O09131 (/ISO)
Xenobiotic catabolic process GO:0042178
The chemical reactions and pathways resulting in the breakdown of a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide.
1 O09131 (/ISO)
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
1 Q9H4Y5 (/IDA)
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
1 Q8K2Q2 (/ISO)
Negative regulation of ryanodine-sensitive calcium-release channel activity GO:0060315
Any process that decreases the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts.
1 O09131 (/ISO)
Positive regulation of ryanodine-sensitive calcium-release channel activity GO:0060316
Any process that increases the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts.
1 O09131 (/ISO)

There are 17 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 P78417 (/IDA) P78417 (/IDA) Q9Z339 (/IDA) Q9Z339 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 O09131 (/ISS) Q9N1F5 (/ISS) Q9N1F5 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 P78417 (/TAS) P78417 (/TAS) Q9H4Y5 (/TAS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
3 P78417 (/HDA) P78417 (/HDA) Q9H4Y5 (/HDA)
Basement membrane GO:0005604
A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.
2 Q9Z339 (/IDA) Q9Z339 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q9Z339 (/IDA) Q9Z339 (/IDA)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
2 Q9Z339 (/IDA) Q9Z339 (/IDA)
Nuclear membrane GO:0031965
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
2 Q9Z339 (/IDA) Q9Z339 (/IDA)
Myelin sheath GO:0043209
An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.
2 Q9Z339 (/IDA) Q9Z339 (/IDA)
Cell body GO:0044297
The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.
2 Q9Z339 (/IDA) Q9Z339 (/IDA)
Basement membrane GO:0005604
A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.
1 O09131 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 O09131 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 O09131 (/ISO)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
1 O09131 (/ISO)
Nuclear membrane GO:0031965
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
1 O09131 (/ISO)
Myelin sheath GO:0043209
An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.
1 O09131 (/ISO)
Cell body GO:0044297
The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.
1 O09131 (/ISO)