The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Glutaredoxin
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Alkyl hydroperoxide reductase C

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 16 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
237 O97161 (/IPI) P0AE08 (/IPI) P0AE08 (/IPI) P0AE08 (/IPI) P0AE08 (/IPI) P0AE08 (/IPI) P0AE08 (/IPI) P0AE08 (/IPI) P0AE08 (/IPI) P0AE08 (/IPI)
(227 more)
Peroxidase activity GO:0004601
Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O.
178 P0AE08 (/IGI) P0AE08 (/IGI) P0AE08 (/IGI) P0AE08 (/IGI) P0AE08 (/IGI) P0AE08 (/IGI) P0AE08 (/IGI) P0AE08 (/IGI) P0AE08 (/IGI) P0AE08 (/IGI)
(168 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
178 P0AE08 (/IPI) P0AE08 (/IPI) P0AE08 (/IPI) P0AE08 (/IPI) P0AE08 (/IPI) P0AE08 (/IPI) P0AE08 (/IPI) P0AE08 (/IPI) P0AE08 (/IPI) P0AE08 (/IPI)
(168 more)
Oxidoreductase activity, acting on peroxide as acceptor GO:0016684
Catalysis of an oxidation-reduction (redox) reaction in which the peroxide group acts as a hydrogen or electron acceptor.
178 P0AE08 (/IMP) P0AE08 (/IMP) P0AE08 (/IMP) P0AE08 (/IMP) P0AE08 (/IMP) P0AE08 (/IMP) P0AE08 (/IMP) P0AE08 (/IMP) P0AE08 (/IMP) P0AE08 (/IMP)
(168 more)
Hydroperoxide reductase activity GO:0032843
Catalysis of the reaction: 2 RSH + ROOH = RSSR + ROH + H2O. This reaction is the thiol-dependent conversion of an organic hydroperoxide to the corresponding alcohol.
178 P0AE08 (/IDA) P0AE08 (/IDA) P0AE08 (/IDA) P0AE08 (/IDA) P0AE08 (/IDA) P0AE08 (/IDA) P0AE08 (/IDA) P0AE08 (/IDA) P0AE08 (/IDA) P0AE08 (/IDA)
(168 more)
Alkyl hydroperoxide reductase activity GO:0008785
Catalysis of the reaction: octane hydroperoxide + NADH + H+ = H2O + NAD+ + 1-octanol.
71 A0A0J1HRG9 (/ISS) A0A0J1HRG9 (/ISS) A0A0J1HRG9 (/ISS) A0A0J1HRG9 (/ISS) A0A0J1HRG9 (/ISS) A0A0J1HRG9 (/ISS) A0A0J1HRG9 (/ISS) A0A0J1HRG9 (/ISS) A0A0J1HRG9 (/ISS) A0A0J1HRG9 (/ISS)
(61 more)
Thioredoxin peroxidase activity GO:0008379
Catalysis of the reaction: thioredoxin + hydrogen peroxide = thioredoxin disulfide + H2O.
32 Q8I5Q6 (/IDA) Q8I5Q6 (/IDA) Q8I5Q6 (/IDA) Q8I5Q6 (/IDA) Q8I5Q6 (/IDA) Q8I5Q6 (/IDA) Q8I5Q6 (/IDA) Q8I5Q6 (/IDA) Q8I5Q6 (/IDA) Q8I5Q6 (/IDA)
(22 more)
Antioxidant activity GO:0016209
Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage.
15 Q8IL80 (/IDA) Q8IL80 (/IDA) Q8IL80 (/IDA) Q8IL80 (/IDA) Q8IL80 (/IDA) Q8IL80 (/IDA) Q8IL80 (/IDA) Q8IL80 (/IDA) Q8IL80 (/IDA) Q8IL80 (/IDA)
(5 more)
Protein dimerization activity GO:0046983
The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.
15 Q8IL80 (/IDA) Q8IL80 (/IDA) Q8IL80 (/IDA) Q8IL80 (/IDA) Q8IL80 (/IDA) Q8IL80 (/IDA) Q8IL80 (/IDA) Q8IL80 (/IDA) Q8IL80 (/IDA) Q8IL80 (/IDA)
(5 more)
Alkyl hydroperoxide reductase activity GO:0008785
Catalysis of the reaction: octane hydroperoxide + NADH + H+ = H2O + NAD+ + 1-octanol.
13 Q9HY81 (/IDA) Q9HY81 (/IDA) Q9HY81 (/IDA) Q9HY81 (/IDA) Q9HY81 (/IDA) Q9HY81 (/IDA) Q9HY81 (/IDA) Q9HY81 (/IDA) Q9HY81 (/IDA) Q9HY81 (/IDA)
(3 more)
Trypanothione-disulfide reductase activity GO:0015042
Catalysis of the reaction: NADP+ + trypanothione = NADPH + H+ + trypanothione disulfide.
10 D6XKT6 (/IDA) D6XKT6 (/IDA) D6XKT6 (/IDA) D6XKT6 (/IDA) D6XKT6 (/IDA) Q9GU47 (/IDA) Q9GU47 (/IDA) Q9GU47 (/IDA) Q9GU47 (/IDA) Q9GU47 (/IDA)
Antioxidant activity GO:0016209
Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage.
8 Q9KTZ9 (/ISS) Q9KTZ9 (/ISS) Q9KTZ9 (/ISS) Q9KTZ9 (/ISS) Q9KTZ9 (/ISS) Q9KTZ9 (/ISS) Q9KTZ9 (/ISS) Q9VEJ0 (/ISS)
Thioredoxin peroxidase activity GO:0008379
Catalysis of the reaction: thioredoxin + hydrogen peroxide = thioredoxin disulfide + H2O.
2 Q747L9 (/ISS) Q747L9 (/ISS)
Peroxidase activity GO:0004601
Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O.
1 Q95U89 (/IMP)
Peroxiredoxin activity GO:0051920
Catalysis of the reaction: 2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.
1 Q95U89 (/IDA)
Peroxiredoxin activity GO:0051920
Catalysis of the reaction: 2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.
1 Q95U89 (/IMP)

There are 19 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cellular response to sulfate starvation GO:0009970
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of sulfate.
178 P0AE08 (/IDA) P0AE08 (/IDA) P0AE08 (/IDA) P0AE08 (/IDA) P0AE08 (/IDA) P0AE08 (/IDA) P0AE08 (/IDA) P0AE08 (/IDA) P0AE08 (/IDA) P0AE08 (/IDA)
(168 more)
Siderophore biosynthetic process GO:0019290
The chemical reactions and pathways resulting in the formation of siderophores, low molecular weight Fe(III)-chelating substances made by aerobic or facultatively anaerobic bacteria, especially when growing under iron deficient conditions. The complexes of Fe(3+)-siderophores have very high stability constants and are taken up by specific transport systems by microorganisms; the subsequent release of iron requires enzymatic action.
178 P0AE08 (/IMP) P0AE08 (/IMP) P0AE08 (/IMP) P0AE08 (/IMP) P0AE08 (/IMP) P0AE08 (/IMP) P0AE08 (/IMP) P0AE08 (/IMP) P0AE08 (/IMP) P0AE08 (/IMP)
(168 more)
Response to hydroperoxide GO:0033194
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroperoxide stimulus. Hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH.
178 P0AE08 (/IMP) P0AE08 (/IMP) P0AE08 (/IMP) P0AE08 (/IMP) P0AE08 (/IMP) P0AE08 (/IMP) P0AE08 (/IMP) P0AE08 (/IMP) P0AE08 (/IMP) P0AE08 (/IMP)
(168 more)
Response to alkyl hydroperoxide GO:0033195
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkyl hydroperoxide stimulus. Alkyl hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH, where the substituent is an alkyl group.
178 P0AE08 (/IMP) P0AE08 (/IMP) P0AE08 (/IMP) P0AE08 (/IMP) P0AE08 (/IMP) P0AE08 (/IMP) P0AE08 (/IMP) P0AE08 (/IMP) P0AE08 (/IMP) P0AE08 (/IMP)
(168 more)
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
31 Q8I5Q6 (/IDA) Q8I5Q6 (/IDA) Q8I5Q6 (/IDA) Q8I5Q6 (/IDA) Q8I5Q6 (/IDA) Q8I5Q6 (/IDA) Q8I5Q6 (/IDA) Q8I5Q6 (/IDA) Q8I5Q6 (/IDA) Q8I5Q6 (/IDA)
(21 more)
Response to heat GO:0009408
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
15 Q8IL80 (/IDA) Q8IL80 (/IDA) Q8IL80 (/IDA) Q8IL80 (/IDA) Q8IL80 (/IDA) Q8IL80 (/IDA) Q8IL80 (/IDA) Q8IL80 (/IDA) Q8IL80 (/IDA) Q8IL80 (/IDA)
(5 more)
DNA protection GO:0042262
Any process in which DNA is protected from damage by, for example, oxidative stress.
15 Q8IL80 (/IDA) Q8IL80 (/IDA) Q8IL80 (/IDA) Q8IL80 (/IDA) Q8IL80 (/IDA) Q8IL80 (/IDA) Q8IL80 (/IDA) Q8IL80 (/IDA) Q8IL80 (/IDA) Q8IL80 (/IDA)
(5 more)
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
10 D6XKT6 (/TAS) D6XKT6 (/TAS) D6XKT6 (/TAS) D6XKT6 (/TAS) D6XKT6 (/TAS) Q9GU47 (/TAS) Q9GU47 (/TAS) Q9GU47 (/TAS) Q9GU47 (/TAS) Q9GU47 (/TAS)
Removal of superoxide radicals GO:0019430
Any process, acting at the cellular level, involved in removing superoxide radicals (O2-) from a cell or organism, e.g. by conversion to dioxygen (O2) and hydrogen peroxide (H2O2).
2 Q747L9 (/ISS) Q747L9 (/ISS)
Determination of adult lifespan GO:0008340
The control of viability and duration in the adult phase of the life-cycle.
1 Q9VEJ0 (/IGI)
Hydrogen peroxide catabolic process GO:0042744
The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2).
1 Q9VEJ0 (/IDA)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
1 Q9VEJ0 (/IGI)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
1 Q9VEJ0 (/IMP)
Symbiont process GO:0044403
A process carried out by symbiont gene products that enables the interaction between two organisms living together in more or less intimate association. The various forms of symbiosis include parasitism, in which the association is disadvantageous or destructive to one of the organisms; mutualism, in which the association is advantageous, or often necessary to one or both and not harmful to either; and commensalism, in which one member of the association benefits while the other is not affected. However, mutualism, parasitism, and commensalism are often not discrete categories of interactions and should rather be perceived as a continuum of interaction ranging from parasitism to mutualism. In fact, the direction of a symbiotic interaction can change during the lifetime of the symbionts due to developmental changes as well as changes in the biotic/abiotic environment in which the interaction occurs. Microscopic symbionts are often referred to as endosymbionts.
1 Q95U89 (/IMP)
Cell redox homeostasis GO:0045454
Any process that maintains the redox environment of a cell or compartment within a cell.
1 Q9VEJ0 (/IGI)
Cell redox homeostasis GO:0045454
Any process that maintains the redox environment of a cell or compartment within a cell.
1 Q9VEJ0 (/ISS)
Chaperone-mediated protein folding GO:0061077
The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone.
1 Q95U89 (/IMP)
Cellular oxidant detoxification GO:0098869
Any process carried out at the cellular level that reduces or removes the toxicity superoxide radicals or hydrogen peroxide.
1 Q95U89 (/IDA)
Cellular oxidant detoxification GO:0098869
Any process carried out at the cellular level that reduces or removes the toxicity superoxide radicals or hydrogen peroxide.
1 Q95U89 (/IMP)

There are 11 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
193 P0AE08 (/IDA) P0AE08 (/IDA) P0AE08 (/IDA) P0AE08 (/IDA) P0AE08 (/IDA) P0AE08 (/IDA) P0AE08 (/IDA) P0AE08 (/IDA) P0AE08 (/IDA) P0AE08 (/IDA)
(183 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
178 P0AE08 (/IDA) P0AE08 (/IDA) P0AE08 (/IDA) P0AE08 (/IDA) P0AE08 (/IDA) P0AE08 (/IDA) P0AE08 (/IDA) P0AE08 (/IDA) P0AE08 (/IDA) P0AE08 (/IDA)
(168 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
178 P0AE08 (/HDA) P0AE08 (/HDA) P0AE08 (/HDA) P0AE08 (/HDA) P0AE08 (/HDA) P0AE08 (/HDA) P0AE08 (/HDA) P0AE08 (/HDA) P0AE08 (/HDA) P0AE08 (/HDA)
(168 more)
Alkyl hydroperoxide reductase complex GO:0009321
An enzyme complex, usually a homodimer, which directly reduces cellular levels of organic hydroperoxides.
178 P0AE08 (/IDA) P0AE08 (/IDA) P0AE08 (/IDA) P0AE08 (/IDA) P0AE08 (/IDA) P0AE08 (/IDA) P0AE08 (/IDA) P0AE08 (/IDA) P0AE08 (/IDA) P0AE08 (/IDA)
(168 more)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
178 P0AE08 (/HDA) P0AE08 (/HDA) P0AE08 (/HDA) P0AE08 (/HDA) P0AE08 (/HDA) P0AE08 (/HDA) P0AE08 (/HDA) P0AE08 (/HDA) P0AE08 (/HDA) P0AE08 (/HDA)
(168 more)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
28 D6XKT6 (/IDA) D6XKT6 (/IDA) D6XKT6 (/IDA) D6XKT6 (/IDA) D6XKT6 (/IDA) Q8I5Q6 (/IDA) Q8I5Q6 (/IDA) Q8I5Q6 (/IDA) Q8I5Q6 (/IDA) Q8I5Q6 (/IDA)
(18 more)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
10 D6XKT6 (/RCA) D6XKT6 (/RCA) D6XKT6 (/RCA) D6XKT6 (/RCA) D6XKT6 (/RCA) Q9GU47 (/RCA) Q9GU47 (/RCA) Q9GU47 (/RCA) Q9GU47 (/RCA) Q9GU47 (/RCA)
Ciliary basal body GO:0036064
A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport.
10 D6XKT6 (/IDA) D6XKT6 (/IDA) D6XKT6 (/IDA) D6XKT6 (/IDA) D6XKT6 (/IDA) Q9GU47 (/IDA) Q9GU47 (/IDA) Q9GU47 (/IDA) Q9GU47 (/IDA) Q9GU47 (/IDA)
Ciliary basal body GO:0036064
A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport.
2 Q4QBH2 (/ISO) Q4QBH2 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q9VEJ0 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q9VEJ0 (/ISS)