The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Leucine Aminopeptidase, subunit E, domain 1
".
FunFam 12: Protein mono-ADP-ribosyltransferase PARP9
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 17 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
1 | Q8IXQ6 (/IMP) |
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
1 | Q8CAS9 (/ISO) |
|
NAD+ ADP-ribosyltransferase activity GO:0003950
Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
|
1 | Q8IXQ6 (/IDA) |
|
NAD+ ADP-ribosyltransferase activity GO:0003950
Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.
|
1 | Q8CAS9 (/ISS) |
|
Enzyme inhibitor activity GO:0004857
Binds to and stops, prevents or reduces the activity of an enzyme.
|
1 | Q8IXQ6 (/IDA) |
|
Enzyme inhibitor activity GO:0004857
Binds to and stops, prevents or reduces the activity of an enzyme.
|
1 | Q8CAS9 (/ISO) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | Q8IXQ6 (/IPI) |
|
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
|
1 | Q8IXQ6 (/IPI) |
|
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
|
1 | Q8CAS9 (/ISO) |
|
Histone binding GO:0042393
Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.
|
1 | Q8IXQ6 (/IPI) |
|
Histone binding GO:0042393
Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.
|
1 | Q8CAS9 (/ISO) |
|
Ubiquitin-like protein ligase binding GO:0044389
Interacting selectively and non-covalently with a ubiquitin-like protein ligase, such as ubiquitin-ligase.
|
1 | Q8IXQ6 (/IPI) |
|
Ubiquitin-like protein ligase binding GO:0044389
Interacting selectively and non-covalently with a ubiquitin-like protein ligase, such as ubiquitin-ligase.
|
1 | Q8CAS9 (/ISO) |
|
ADP-D-ribose binding GO:0072570
Interacting selectively and non-covalently with ADP-D-ribose, an ADP-aldose having ribose as the aldose fragment.
|
1 | Q8IXQ6 (/IMP) |
|
ADP-D-ribose binding GO:0072570
Interacting selectively and non-covalently with ADP-D-ribose, an ADP-aldose having ribose as the aldose fragment.
|
1 | Q8CAS9 (/ISO) |
|
STAT family protein binding GO:0097677
Interacting selectively and non-covalently with any member of the signal transducers and activators of transcription (STAT) protein family. STATs are, as the name indicates, both signal transducers and transcription factors. STATs are activated by cytokines and some growth factors and thus control important biological processes including cell growth, cell differentiation, apoptosis and immune responses.
|
1 | Q8IXQ6 (/IPI) |
|
STAT family protein binding GO:0097677
Interacting selectively and non-covalently with any member of the signal transducers and activators of transcription (STAT) protein family. STATs are, as the name indicates, both signal transducers and transcription factors. STATs are activated by cytokines and some growth factors and thus control important biological processes including cell growth, cell differentiation, apoptosis and immune responses.
|
1 | Q8CAS9 (/ISO) |
There are 32 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Positive regulation of interferon-gamma-mediated signaling pathway GO:0060335
Any process that increases the rate, frequency or extent of the series of molecular events generated as a consequence of interferon-gamma binding to a cell surface receptor.
|
2 | Q8CAS9 (/IMP) Q8IXQ6 (/IMP) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
1 | Q8IXQ6 (/IMP) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
1 | Q8CAS9 (/ISO) |
|
Positive regulation of defense response to virus by host GO:0002230
Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication.
|
1 | Q8IXQ6 (/IGI) |
|
Positive regulation of defense response to virus by host GO:0002230
Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication.
|
1 | Q8CAS9 (/ISO) |
|
Double-strand break repair GO:0006302
The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.
|
1 | Q8IXQ6 (/IMP) |
|
Double-strand break repair GO:0006302
The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.
|
1 | Q8CAS9 (/ISO) |
|
Double-strand break repair GO:0006302
The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.
|
1 | Q8CAS9 (/ISS) |
|
Protein ADP-ribosylation GO:0006471
The transfer, from NAD, of ADP-ribose to protein amino acids.
|
1 | Q8IXQ6 (/IDA) |
|
Protein ADP-ribosylation GO:0006471
The transfer, from NAD, of ADP-ribose to protein amino acids.
|
1 | Q8CAS9 (/ISO) |
|
Posttranscriptional regulation of gene expression GO:0010608
Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript.
|
1 | Q8IXQ6 (/IMP) |
|
Posttranscriptional regulation of gene expression GO:0010608
Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript.
|
1 | Q8CAS9 (/ISO) |
|
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
1 | Q8IXQ6 (/IMP) |
|
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
1 | Q8CAS9 (/ISO) |
|
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
|
1 | Q8IXQ6 (/TAS) |
|
NAD biosynthesis via nicotinamide riboside salvage pathway GO:0034356
The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD) from the vitamin precursor nicotinamide riboside.
|
1 | Q8IXQ6 (/TAS) |
|
Positive regulation of chromatin binding GO:0035563
Any process that increases the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
1 | Q8IXQ6 (/IGI) |
|
Positive regulation of chromatin binding GO:0035563
Any process that increases the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
1 | Q8CAS9 (/ISO) |
|
Positive regulation of tyrosine phosphorylation of STAT protein GO:0042531
Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
|
1 | Q8IXQ6 (/IMP) |
|
Positive regulation of tyrosine phosphorylation of STAT protein GO:0042531
Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
|
1 | Q8CAS9 (/ISO) |
|
Negative regulation of catalytic activity GO:0043086
Any process that stops or reduces the activity of an enzyme.
|
1 | Q8IXQ6 (/IDA) |
|
Negative regulation of catalytic activity GO:0043086
Any process that stops or reduces the activity of an enzyme.
|
1 | Q8CAS9 (/ISO) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q8IXQ6 (/IGI) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q8CAS9 (/ISO) |
|
Regulation of response to interferon-gamma GO:0060330
Any process that modulates the rate, frequency or extent of a response to interferon-gamma. Response to interferon gamma is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus.
|
1 | Q8IXQ6 (/IDA) |
|
Regulation of response to interferon-gamma GO:0060330
Any process that modulates the rate, frequency or extent of a response to interferon-gamma. Response to interferon gamma is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus.
|
1 | Q8CAS9 (/ISO) |
|
Regulation of response to interferon-gamma GO:0060330
Any process that modulates the rate, frequency or extent of a response to interferon-gamma. Response to interferon gamma is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus.
|
1 | Q8CAS9 (/ISS) |
|
Positive regulation of interferon-gamma-mediated signaling pathway GO:0060335
Any process that increases the rate, frequency or extent of the series of molecular events generated as a consequence of interferon-gamma binding to a cell surface receptor.
|
1 | Q8CAS9 (/ISO) |
|
Positive regulation of protein localization to nucleus GO:1900182
Any process that activates or increases the frequency, rate or extent of protein localization to nucleus.
|
1 | Q8IXQ6 (/IGI) |
|
Positive regulation of protein localization to nucleus GO:1900182
Any process that activates or increases the frequency, rate or extent of protein localization to nucleus.
|
1 | Q8CAS9 (/ISO) |
|
Positive regulation of double-strand break repair via nonhomologous end joining GO:2001034
Any process that activates or increases the frequency, rate or extent of double-strand break repair via nonhomologous end joining.
|
1 | Q8IXQ6 (/IMP) |
|
Positive regulation of double-strand break repair via nonhomologous end joining GO:2001034
Any process that activates or increases the frequency, rate or extent of double-strand break repair via nonhomologous end joining.
|
1 | Q8CAS9 (/ISO) |
There are 20 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q8IXQ6 (/IC) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q8IXQ6 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q8CAS9 (/ISO) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q8CAS9 (/ISS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q8IXQ6 (/TAS) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | Q8IXQ6 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | Q8CAS9 (/ISO) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q8IXQ6 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q8CAS9 (/ISO) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q8CAS9 (/ISS) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
1 | Q8IXQ6 (/IDA) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
1 | Q8CAS9 (/ISO) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q8IXQ6 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q8CAS9 (/ISO) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q8IXQ6 (/TAS) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | Q8IXQ6 (/HDA) |
|
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
|
1 | Q8IXQ6 (/IDA) |
|
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
|
1 | Q8CAS9 (/ISO) |
|
Site of DNA damage GO:0090734
A region of a chromosome at which DNA damage has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.
|
1 | Q8IXQ6 (/IDA) |
|
Site of DNA damage GO:0090734
A region of a chromosome at which DNA damage has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.
|
1 | Q8CAS9 (/ISO) |