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CATH Superfamily 3.40.1440.10

GIY-YIG endonuclease

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
GIY-YIG endonuclease
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 7: I-TevI homing endonuclease

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
 27 P13299 (/IMP) P13299 (/IMP) P13299 (/IMP) P13299 (/IMP) P13299 (/IMP) P13299 (/IMP) P13299 (/IMP) P13299 (/IMP) P13299 (/IMP) P13299 (/IMP)
(17 more)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
 27 P13299 (/IDA) P13299 (/IDA) P13299 (/IDA) P13299 (/IDA) P13299 (/IDA) P13299 (/IDA) P13299 (/IDA) P13299 (/IDA) P13299 (/IDA) P13299 (/IDA)
(17 more)
Endonuclease activity GO:0004519
Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks.
 27 P13299 (/IDA) P13299 (/IDA) P13299 (/IDA) P13299 (/IDA) P13299 (/IDA) P13299 (/IDA) P13299 (/IDA) P13299 (/IDA) P13299 (/IDA) P13299 (/IDA)
(17 more)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
 27 P13299 (/IMP) P13299 (/IMP) P13299 (/IMP) P13299 (/IMP) P13299 (/IMP) P13299 (/IMP) P13299 (/IMP) P13299 (/IMP) P13299 (/IMP) P13299 (/IMP)
(17 more)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
 27 P13299 (/IMP) P13299 (/IMP) P13299 (/IMP) P13299 (/IMP) P13299 (/IMP) P13299 (/IMP) P13299 (/IMP) P13299 (/IMP) P13299 (/IMP) P13299 (/IMP)
(17 more)

There are 2 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
 27 P13299 (/IMP) P13299 (/IMP) P13299 (/IMP) P13299 (/IMP) P13299 (/IMP) P13299 (/IMP) P13299 (/IMP) P13299 (/IMP) P13299 (/IMP) P13299 (/IMP)
(17 more)
Nucleic acid phosphodiester bond hydrolysis GO:0090305
The nucleic acid metabolic process in which the phosphodiester bonds between nucleotides are cleaved by hydrolysis.
 27 P13299 (/IDA) P13299 (/IDA) P13299 (/IDA) P13299 (/IDA) P13299 (/IDA) P13299 (/IDA) P13299 (/IDA) P13299 (/IDA) P13299 (/IDA) P13299 (/IDA)
(17 more)

There are 1 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Transcriptional repressor complex GO:0017053
A protein complex that possesses activity that prevents or downregulates transcription.
 27 P13299 (/IMP) P13299 (/IMP) P13299 (/IMP) P13299 (/IMP) P13299 (/IMP) P13299 (/IMP) P13299 (/IMP) P13299 (/IMP) P13299 (/IMP) P13299 (/IMP)
(17 more)