The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"GIY-YIG endonuclease
".
FunFam 12: Structure-specific endonuclease subunit SLX1 homol...
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 3 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
2 | Q9P7M3 (/IPI) Q9VN41 (/IPI) |
|
Endodeoxyribonuclease activity GO:0004520
Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks.
|
1 | Q9VN41 (/ISS) |
|
Endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters GO:0016893
Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 5'-phosphomonoesters.
|
1 | Q9P7M3 (/IDA) |
There are 3 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Double-strand break repair via homologous recombination GO:0000724
The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule.
|
1 | Q9P7M3 (/IGI) |
|
Replication fork processing GO:0031297
The process in which a DNA replication fork that has stalled is restored to a functional state and replication is restarted. The stalling may be due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes.
|
1 | Q9P7M3 (/TAS) |
|
Recombination within rDNA repeats GO:0045458
Genetic recombination within the DNA of the genes coding for ribosomal RNA.
|
1 | Q9P7M3 (/IDA) |
There are 4 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Slx1-Slx4 complex GO:0033557
A heterodimeric protein complex that possesses an endonuclease activity that specifically cleaves certain types of branched DNA structures; because such structures often form during the replication ribosomal DNA (rDNA) repeats, the complex plays a role in the maintenance of rDNA. The subunits are known as Slx1 and Slx 4 in budding and fission yeasts, and are conserved in eukaryotes.
|
2 | Q9P7M3 (/IDA) Q9VN41 (/IDA) |
|
Nucleolar chromatin GO:0030874
The portion of nuclear chromatin associated with the nucleolus; includes the DNA encoding the ribosomal RNA.
|
1 | Q9P7M3 (/IDA) |
|
RDNA protrusion GO:0030875
Any of the tandem arrays of rDNA localized at the periphery of the nucleus and protruding into the nucleolus, and associated proteins. May be visible as a single or double spot by DAPI staining.
|
1 | Q9P7M3 (/NAS) |
|
Slx1-Slx4 complex GO:0033557
A heterodimeric protein complex that possesses an endonuclease activity that specifically cleaves certain types of branched DNA structures; because such structures often form during the replication ribosomal DNA (rDNA) repeats, the complex plays a role in the maintenance of rDNA. The subunits are known as Slx1 and Slx 4 in budding and fission yeasts, and are conserved in eukaryotes.
|
1 | Q9VN41 (/ISS) |