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CATH Superfamily 3.40.120.10

Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Phosphoglucosamine mutase

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Phosphoglucosamine mutase. [EC: 5.4.2.10]
Alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate.
  • The enzyme is involved in the pathway for bacterial cell-wall peptidoglycan and lipopolysaccharide biosyntheses, being an essential step in the pathway for UDP-N-acetylglucosamine biosynthesis.
  • The enzyme from Escherichia coli is activated by phosphorylation and can be autophosphorylated in vitro by alpha-D-glucosamine 1,6- bisphosphate, which is an intermediate in the reaction, alpha-D- glucose 1,6-bisphosphate or ATP.
  • It can also catalyze the interconversion of alpha-D-glucose 1-phosphate and alpha-D-glucose 6-phosphate, although at a much lower rate.
 24916 A0A023P1M1 A0A023P1M1 A0A023P1M1 A0A023P1M1 A0A023P1M1 A0A023P1M1 A0A023P1M1 A0A023P1M1 A0A023P1M1 A0A023P1M1
(24906 more...)
Phosphomannomutase. [EC: 5.4.2.8]
Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.
  • Alpha-D-mannose 1,6-bisphosphate or alpha-D-glucose 1,6-bisphosphate can act as cofactor.
  • Formerly EC 2.7.5.7.
 47 A0A0H3AIN5 A0A0H3AIN5 A0A0H3AIN5 A0A0H3AIN5 A0A0H3AIN5 A0A0H3AIN5 A0A0H6UQV2 A0A0H6UQV2 A0A0H6UQV2 A0A0H6UQV2
(37 more...)
Phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent). [EC: 5.4.2.2]
Alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate.
  • Maximum activity is only obtained in the presence of alpha-D-glucose 1,6-bisphosphate.
  • This bisphosphate is an intermediate in the reaction, being formed by transfer of a phosphate residue from the enzyme to the substrate, but the dissociation of bisphosphate from the enzyme complex is much slower than the overall isomerization.
  • Also, more slowly, catalyzes the interconversion of 1-phosphate and 6-phosphate isomers of many other alpha-D-hexoses, and the interconversion of alpha-D-ribose 1-phosphate and 5-phosphate.
  • Cf. EC 5.4.2.5.
  • Formerly EC 2.7.5.1.
 11 A0A2V3FAA0 A0A2V3FAA0 A0A2V3FAA0 P26276 P26276 P26276 Q02E40 Q02E40 Q02E40 Q68BJ6
(1 more...)
Phosphopentomutase. [EC: 5.4.2.7]
Alpha-D-ribose 1-phosphate = D-ribose 5-phosphate.
  • Also converts 2-deoxy-alpha-D-ribose 1-phosphate into 2-deoxy-D- ribose 5-phosphate.
  • Alpha-D-ribose 1,5-bisphosphate, 2-deoxy-alpha-D-ribose 1,5- bisphosphate, or alpha-D-glucose 1,6-bisphosphate can act as cofactor.
  • Formerly EC 2.7.5.6.
 1 Q6I7B6