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CATH Superfamily 3.40.1180.10

Decaprenyl diphosphate synthase-like

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Decaprenyl diphosphate synthase-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4: Isoprenyl transferase

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Trans,polycis-decaprenyl diphosphate synthase. [EC: 2.5.1.86]
(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate.
  • The enzyme is involved in the biosynthesis of decaprenyl phosphate, which plays a central role in the biosynthesis of essential mycobacterial cell wall components, such as the mycolyl- arabinogalactan-peptidoglycan complex and lipoarabinomannan.
 119 A0A045I716 A0A045I716 A0A045I716 A0A045I716 A0A045I716 A0A045I716 A0A045I716 A0A045I716 A0A045I716 A0A045I716
(109 more...)
Ditrans,polycis-polyprenyl diphosphate synthase ((2E,6E)-farnesyl diphosphate specific). [EC: 2.5.1.87]
(2E,6E)-farnesyl diphosphate + n isopentenyl diphosphate = n diphosphate + ditrans,polycis-polyprenyl diphosphate (n = 10-55).
  • The enzyme is involved in biosynthesis of dolichol (a long-chain polyprenol) with a saturated alpha-isoprene unit, which serves as a glycosyl carrier in protein glycosylation.
  • The yeast Saccharomyces cerevisiae has two different enzymes that catalyze this reaction.
  • Rer2p synthesizes a well-defined family of polyprenols of 13-18 isoprene residues with dominating C(80) (16 isoprene residues) extending to C(120), while Srt1p synthesizes mainly polyprenol with 22 isoprene subunits.
  • Largest Srt1p products reach C(290).
  • The enzyme from Arabidopsis thaliana catalyzes the formation of polyprenyl diphosphates with predominant carbon number C(120).
 119 A0A045I716 A0A045I716 A0A045I716 A0A045I716 A0A045I716 A0A045I716 A0A045I716 A0A045I716 A0A045I716 A0A045I716
(109 more...)
Trans,polycis-polyprenyl diphosphate synthase ((2Z,6E)-farnesyl diphosphate specific). [EC: 2.5.1.88]
(2Z,6E)-farnesyl diphosphate + n isopentenyl diphosphate = n diphosphate + trans,polycis-polyprenyl diphosphate (n = 9-11).
  • Highest activity with (2Z,6E)-farnesyl diphosphate as allylic substrate.
  • Broad product specificity with the major product being dodecaprenyl diphosphate.
  • Synthesizes even C(70) prenyl diphosphate as the maximum chain-length product.
 1 Q47RM6