The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Cytosolic phospholipase A2 catalytic domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 6: 85/88 kDa calcium-independent phospholipase A2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Phospholipase A2 activity GO:0004623
Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.
2 O60733 (/TAS) P97570 (/TAS)
Hydrolase activity GO:0016787
Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.
1 O60733 (/TAS)
Serine hydrolase activity GO:0017171
Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
1 P97819 (/IDA)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
1 P97570 (/IPI)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
1 P97819 (/ISO)
ATP-dependent protein binding GO:0043008
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) using energy from the hydrolysis of ATP.
1 P97570 (/IDA)
ATP-dependent protein binding GO:0043008
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) using energy from the hydrolysis of ATP.
1 P97819 (/ISO)
Calcium-independent phospholipase A2 activity GO:0047499
Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction does not require Ca2+.
1 P97570 (/IDA)
Calcium-independent phospholipase A2 activity GO:0047499
Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction does not require Ca2+.
1 P97819 (/ISO)
Retromer complex binding GO:1905394
Interacting selectively and non-covalently with a retromer complex.
1 Q7KUD4 (/IPI)

There are 42 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Triglyceride homeostasis GO:0070328
Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell.
3 Q7KUD4 (/IMP) Q8MR13 (/IMP) Q9VT60 (/IMP)
Positive regulation of response to oxidative stress GO:1902884
Any process that activates or increases the frequency, rate or extent of response to oxidative stress.
3 Q7KUD4 (/IMP) Q8MR13 (/IMP) Q9VT60 (/IMP)
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
1 P97570 (/IDA)
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
1 P97819 (/ISO)
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
1 P97570 (/IMP)
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
1 P97819 (/ISO)
Memory GO:0007613
The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).
1 P97570 (/IMP)
Memory GO:0007613
The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).
1 P97819 (/ISO)
Urinary bladder smooth muscle contraction GO:0014832
A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the urinary bladder. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The urinary bladder is a musculomembranous sac along the urinary tract.
1 P97570 (/IMP)
Urinary bladder smooth muscle contraction GO:0014832
A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the urinary bladder. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The urinary bladder is a musculomembranous sac along the urinary tract.
1 P97819 (/ISO)
Antibacterial humoral response GO:0019731
An immune response against bacteria mediated through a body fluid. Examples of this process are the antibacterial humoral responses in Mus musculus and Drosophila melanogaster.
1 O60733 (/IDA)
Antibacterial humoral response GO:0019731
An immune response against bacteria mediated through a body fluid. Examples of this process are the antibacterial humoral responses in Mus musculus and Drosophila melanogaster.
1 P97819 (/ISO)
Cardiolipin biosynthetic process GO:0032049
The chemical reactions and pathways resulting in the formation of cardiolipin, 1,3-bis(3-phosphatidyl)glycerol.
1 O60733 (/IMP)
Cardiolipin biosynthetic process GO:0032049
The chemical reactions and pathways resulting in the formation of cardiolipin, 1,3-bis(3-phosphatidyl)glycerol.
1 P97819 (/ISO)
Response to endoplasmic reticulum stress GO:0034976
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.
1 P97570 (/IDA)
Response to endoplasmic reticulum stress GO:0034976
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.
1 P97819 (/ISO)
Positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774
Any process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.
1 P97570 (/IDA)
Positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774
Any process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.
1 P97819 (/ISO)
Phosphatidylcholine acyl-chain remodeling GO:0036151
Remodeling the acyl chains of phosphatidylcholine, through sequential deacylation and re-acylation reactions, to generate phosphatidylcholine containing different types of fatty acid acyl chains.
1 O60733 (/TAS)
Phosphatidylethanolamine acyl-chain remodeling GO:0036152
Remodeling the acyl chains of phosphatidylethanolamine, through sequential deacylation and re-acylation reactions, to generate phosphatidylethanolamine containing different types of fatty acid acyl chains.
1 O60733 (/TAS)
Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096
An Fc-gamma receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes.
1 O60733 (/TAS)
Positive regulation of exocytosis GO:0045921
Any process that activates or increases the frequency, rate or extent of exocytosis.
1 P97570 (/IMP)
Positive regulation of exocytosis GO:0045921
Any process that activates or increases the frequency, rate or extent of exocytosis.
1 P97819 (/ISO)
Negative regulation of synaptic transmission, glutamatergic GO:0051967
Any process that stops, prevents, or reduces the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate.
1 P97570 (/IMP)
Negative regulation of synaptic transmission, glutamatergic GO:0051967
Any process that stops, prevents, or reduces the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate.
1 P97819 (/ISO)
Maternal process involved in female pregnancy GO:0060135
A reproductive process occurring in the mother that allows an embryo or fetus to develop within it.
1 P97570 (/IEP)
Positive regulation of protein kinase C signaling GO:0090037
Any process that increases the frequency, rate, or extent of a series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound.
1 P97570 (/IMP)
Positive regulation of protein kinase C signaling GO:0090037
Any process that increases the frequency, rate, or extent of a series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound.
1 P97819 (/ISO)
Regulation of sphingolipid biosynthetic process GO:0090153
Any process that modulates the rate, frequency or extent of sphingolipid biosynthesis. Sphingolipid biosynthesis is the chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).
1 Q7KUD4 (/IDA)
Positive regulation of release of cytochrome c from mitochondria GO:0090200
Any process that increases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation.
1 P97570 (/IDA)
Positive regulation of release of cytochrome c from mitochondria GO:0090200
Any process that increases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation.
1 P97819 (/ISO)
Positive regulation of arachidonic acid secretion GO:0090238
Any process that increases the rate, frequency, or extent of arachidonic acid secretion, the controlled release of arachidonic acid from a cell or a tissue.
1 P97570 (/IDA)
Positive regulation of arachidonic acid secretion GO:0090238
Any process that increases the rate, frequency, or extent of arachidonic acid secretion, the controlled release of arachidonic acid from a cell or a tissue.
1 P97570 (/IMP)
Positive regulation of arachidonic acid secretion GO:0090238
Any process that increases the rate, frequency, or extent of arachidonic acid secretion, the controlled release of arachidonic acid from a cell or a tissue.
1 P97819 (/ISO)
Positive regulation of blood vessel diameter GO:0097755
Any process that increases the diameter of blood vessels.
1 P97570 (/IMP)
Positive regulation of blood vessel diameter GO:0097755
Any process that increases the diameter of blood vessels.
1 P97819 (/ISO)
Regulation of store-operated calcium channel activity GO:1901339
Any process that modulates the frequency, rate or extent of store-operated calcium channel activity.
1 P97570 (/IMP)
Regulation of store-operated calcium channel activity GO:1901339
Any process that modulates the frequency, rate or extent of store-operated calcium channel activity.
1 P97819 (/ISO)
Regulation of ceramide biosynthetic process GO:2000303
Any process that modulates the frequency, rate or extent of a ceramide biosynthetic process.
1 Q7KUD4 (/IDA)
Regulation of ceramide biosynthetic process GO:2000303
Any process that modulates the frequency, rate or extent of a ceramide biosynthetic process.
1 Q7KUD4 (/IGI)
Positive regulation of ceramide biosynthetic process GO:2000304
Any process that activates or increases the frequency, rate or extent of ceramide biosynthetic process.
1 P97570 (/IDA)
Positive regulation of ceramide biosynthetic process GO:2000304
Any process that activates or increases the frequency, rate or extent of ceramide biosynthetic process.
1 P97819 (/ISO)

There are 11 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 P97570 (/IDA) Q7KUD4 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 O60733 (/IDA) P97570 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 O60733 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 P97819 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q7KUD4 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 P97819 (/ISO)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
1 P97570 (/TAS)
Microtubule organizing center GO:0005815
An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.
1 O60733 (/IDA)
Microtubule organizing center GO:0005815
An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.
1 P97819 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P97819 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 O60733 (/TAS)