View in Gene3D

CATH Superfamily 3.40.109.10

NADH Oxidase

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
NADH Oxidase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 13: 5,6-dimethylbenzimidazole synthase

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
5,6-dimethylbenzimidazole synthase. [EC: 1.13.11.79]
FMNH(2) + NADH + O(2) = 5,6-dimethylbenzimidazole + D-erythrose 4-phosphate + NAD(+) + other product(s).
  • The enzyme catalyzes a complex oxygen-dependent conversion of reduced flavin mononucleotide to form 5,6-dimethylbenzimidazole, the lower ligand of vitamin B12.
  • This conversion involves many sequential steps in two distinct stages, and an alloxan intermediate that acts as a proton donor, a proton acceptor, and a hydride acceptor.
  • The C-2 of 5,6-dimethylbenzimidazole is derived from C-1' of the ribityl group of FMNH(2) and 2-H from the ribityl 1'-pro-S hydrogen.
  • While D-erythrose 4-phosphate has been shown to be one of the byproducts, the nature of the other product(s) has not been verified yet.
  • Formerly EC 1.14.99.40.
 31 A0A0E0UD01 A0A0E0UD01 A0A0E0UD01 A0A0E0UD01 A0A0E0UD01 A0A0E2PDN6 A0A0E2PDN6 A0A2T3ESE9 A0A2T3ESE9 A0A2T3ESE9
(21 more...)