The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Threonyl-trna Synthetase; Chain A, domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Threonine--tRNA ligase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
92 P0A8M3 (/IPI) P0A8M3 (/IPI) P0A8M3 (/IPI) P0A8M3 (/IPI) P0A8M3 (/IPI) P0A8M3 (/IPI) P0A8M3 (/IPI) P0A8M3 (/IPI) P0A8M3 (/IPI) P0A8M3 (/IPI)
(82 more)
Translation repressor activity, mRNA regulatory element binding GO:0000900
Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding (through a selective and non-covalent interaction) to nucleic acid.
90 P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA)
(80 more)
Aminoacyl-tRNA editing activity GO:0002161
The hydrolysis of an incorrectly aminoacylated tRNA.
90 P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA)
(80 more)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
90 P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA)
(80 more)
Aminoacyl-tRNA ligase activity GO:0004812
Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP.
90 P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA)
(80 more)
Threonine-tRNA ligase activity GO:0004829
Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).
90 P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA)
(80 more)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
90 P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA)
(80 more)
Drug binding GO:0008144
Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease.
90 P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA)
(80 more)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
90 P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA)
(80 more)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
90 P0A8M3 (/IMP) P0A8M3 (/IMP) P0A8M3 (/IMP) P0A8M3 (/IMP) P0A8M3 (/IMP) P0A8M3 (/IMP) P0A8M3 (/IMP) P0A8M3 (/IMP) P0A8M3 (/IMP) P0A8M3 (/IMP)
(80 more)
MRNA 5'-UTR binding GO:0048027
Interacting selectively and non-covalently with the 5' untranslated region of an mRNA molecule.
90 P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA)
(80 more)
Threonine-tRNA ligase activity GO:0004829
Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).
5 Q9KMN7 (/ISS) Q9KMN7 (/ISS) Q9KMN7 (/ISS) Q9KMN7 (/ISS) Q9KMN7 (/ISS)

There are 7 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of translation GO:0006417
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
90 P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA)
(80 more)
TRNA aminoacylation for protein translation GO:0006418
The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis.
90 P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA)
(80 more)
Threonyl-tRNA aminoacylation GO:0006435
The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. The threonyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a threonine-accetping tRNA.
90 P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA)
(80 more)
TRNA aminoacylation GO:0043039
The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules.
90 P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA)
(80 more)
Negative regulation of translational initiation GO:0045947
Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation.
90 P0A8M3 (/IMP) P0A8M3 (/IMP) P0A8M3 (/IMP) P0A8M3 (/IMP) P0A8M3 (/IMP) P0A8M3 (/IMP) P0A8M3 (/IMP) P0A8M3 (/IMP) P0A8M3 (/IMP) P0A8M3 (/IMP)
(80 more)
Threonyl-tRNA aminoacylation GO:0006435
The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. The threonyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a threonine-accetping tRNA.
5 Q9KMN7 (/ISS) Q9KMN7 (/ISS) Q9KMN7 (/ISS) Q9KMN7 (/ISS) Q9KMN7 (/ISS)
Embryo development ending in seed dormancy GO:0009793
The process whose specific outcome is the progression of the embryo over time, from zygote formation to the end of seed dormancy. An example of this process is found in Arabidopsis thaliana.
1 F4IFC5 (/IMP)

There are 6 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
90 P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA)
(80 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
90 P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA) P0A8M3 (/IDA)
(80 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
9 P9WFT5 (/HDA) P9WFT5 (/HDA) P9WFT5 (/HDA) P9WFT5 (/HDA) P9WFT5 (/HDA) P9WFT5 (/HDA) P9WFT5 (/HDA) P9WFT5 (/HDA) P9WFT5 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 F4IFC5 (/IDA)
Chloroplast GO:0009507
A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
1 F4IFC5 (/IDA)
Chloroplast stroma GO:0009570
The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis.
1 F4IFC5 (/IDA)