The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

Schlafen, AAA domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Schlafen, AAA domain

AAA ATPases (ATPases Associated with diverse cellular Activities) form a large protein family and are involved in various cellular processes such as cell-cycle regulation, protein proteolysis and disaggregation, organelle biogenesis and intracellular transport. Some of them function as molecular chaperones, subunits of proteolytic complexes or independent proteases (FtsH, Lon) whilst others act as DNA helicases and transcription factors PMID:17201069, (INTERPRO:IPR003959).

There are at least six major clades of AAA domains and the domain organisation consists of a non-ATPase N-terminal domain involved in substrate recognition, followed by one or two AAA domains (D1 and D2), one of which may be degenerate. AAA domains are responsible for ATP binding and hydrolysis PMID:17201069.

Structural domains comprising this superfamily share the structure of the AAA domain of Schlafen proteins is is believed to be involved, as other AAA domains, in ATP-binding. It is important to note that this superfamily includes several archaeal proteins annotated as ATP-dependent DNA helicases.

GO Diversity

Unique GO annotations
35 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
6688 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 5
Domain clusters (>95% seq id): 2
Domain clusters (>35% seq id): 2
Unique PDBs: 2
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 8
Unique EC:
Unique GO: 35
Unique Species: 6688