The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 341: Hephaestus, isoform C

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 11 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Translation repressor activity, mRNA regulatory element binding GO:0000900
Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding (through a selective and non-covalent interaction) to nucleic acid.
12 A0A0B4K6P4 (/IMP) A0A0B4K6W9 (/IMP) A0A0B4LHY1 (/IMP) A8JRI1 (/IMP) E1JJ45 (/IMP) Q3T7F7 (/IMP) Q7KES3 (/IMP) Q7KRS7 (/IMP) Q8IMF8 (/IMP) Q8T0H5 (/IMP)
(2 more)
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
12 A0A0B4K6P4 (/ISS) A0A0B4K6W9 (/ISS) A0A0B4LHY1 (/ISS) A8JRI1 (/ISS) E1JJ45 (/ISS) Q3T7F7 (/ISS) Q7KES3 (/ISS) Q7KRS7 (/ISS) Q8IMF8 (/ISS) Q8T0H5 (/ISS)
(2 more)
MRNA 3'-UTR binding GO:0003730
Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule.
12 A0A0B4K6P4 (/IDA) A0A0B4K6W9 (/IDA) A0A0B4LHY1 (/IDA) A8JRI1 (/IDA) E1JJ45 (/IDA) Q3T7F7 (/IDA) Q7KES3 (/IDA) Q7KRS7 (/IDA) Q8IMF8 (/IDA) Q8T0H5 (/IDA)
(2 more)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
2 Q18999 (/ISS) Q8T3E6 (/ISS)
Single-stranded DNA endodeoxyribonuclease activity GO:0000014
Catalysis of the hydrolysis of ester linkages within a single-stranded deoxyribonucleic acid molecule by creating internal breaks.
1 P17225 (/ISO)
Regulatory region RNA binding GO:0001069
Interacting selectively and non-covalently with a RNA region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair.
1 P17225 (/ISO)
Single-stranded DNA binding GO:0003697
Interacting selectively and non-covalently with single-stranded DNA.
1 P17225 (/ISO)
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
1 P17225 (/ISO)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 P17225 (/IPI)
Pre-mRNA binding GO:0036002
Interacting selectively and non-covalently with pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule.
1 P17225 (/ISO)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
1 P17225 (/ISO)

There are 28 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Spermatid development GO:0007286
The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure.
12 A0A0B4K6P4 (/IMP) A0A0B4K6W9 (/IMP) A0A0B4LHY1 (/IMP) A8JRI1 (/IMP) E1JJ45 (/IMP) Q3T7F7 (/IMP) Q7KES3 (/IMP) Q7KRS7 (/IMP) Q8IMF8 (/IMP) Q8T0H5 (/IMP)
(2 more)
Sperm individualization GO:0007291
The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane.
12 A0A0B4K6P4 (/IMP) A0A0B4K6W9 (/IMP) A0A0B4LHY1 (/IMP) A8JRI1 (/IMP) E1JJ45 (/IMP) Q3T7F7 (/IMP) Q7KES3 (/IMP) Q7KRS7 (/IMP) Q8IMF8 (/IMP) Q8T0H5 (/IMP)
(2 more)
Negative regulation of oskar mRNA translation GO:0007319
Any process that stops, prevents or reduces the rate that oskar mRNAs are effectively translated into protein.
12 A0A0B4K6P4 (/IMP) A0A0B4K6W9 (/IMP) A0A0B4LHY1 (/IMP) A8JRI1 (/IMP) E1JJ45 (/IMP) Q3T7F7 (/IMP) Q7KES3 (/IMP) Q7KRS7 (/IMP) Q8IMF8 (/IMP) Q8T0H5 (/IMP)
(2 more)
Oocyte microtubule cytoskeleton polarization GO:0008103
Establishment and maintenance of a specific axis of polarity of the oocyte microtubule network. The axis is set so that the minus and plus ends of the microtubules of the mid stage oocyte are positioned along the anterior cortex and at the posterior pole, respectively. An example of this is found in Drosophila melanogaster.
12 A0A0B4K6P4 (/IMP) A0A0B4K6W9 (/IMP) A0A0B4LHY1 (/IMP) A8JRI1 (/IMP) E1JJ45 (/IMP) Q3T7F7 (/IMP) Q7KES3 (/IMP) Q7KRS7 (/IMP) Q8IMF8 (/IMP) Q8T0H5 (/IMP)
(2 more)
Imaginal disc-derived wing vein morphogenesis GO:0008586
The process in which anatomical structures of the veins on an imaginal disc-derived wing are generated and organized.
12 A0A0B4K6P4 (/IMP) A0A0B4K6W9 (/IMP) A0A0B4LHY1 (/IMP) A8JRI1 (/IMP) E1JJ45 (/IMP) Q3T7F7 (/IMP) Q7KES3 (/IMP) Q7KRS7 (/IMP) Q8IMF8 (/IMP) Q8T0H5 (/IMP)
(2 more)
Imaginal disc-derived wing margin morphogenesis GO:0008587
The process in which the anatomical structures of the imaginal disc-derived wing margin are generated and organized. The wing margin is a strip of cells in the third instar disc at the boundary between the presumptive dorsal and ventral surfaces of the wing blade.
12 A0A0B4K6P4 (/IMP) A0A0B4K6W9 (/IMP) A0A0B4LHY1 (/IMP) A8JRI1 (/IMP) E1JJ45 (/IMP) Q3T7F7 (/IMP) Q7KES3 (/IMP) Q7KRS7 (/IMP) Q8IMF8 (/IMP) Q8T0H5 (/IMP)
(2 more)
MRNA splicing, via spliceosome GO:0000398
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
2 Q18999 (/ISS) Q8T3E6 (/ISS)
Regulation of alternative mRNA splicing, via spliceosome GO:0000381
Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.
1 P17225 (/ISO)
Regulation of alternative mRNA splicing, via spliceosome GO:0000381
Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs.
1 P17225 (/ISS)
Nuclear-transcribed mRNA catabolic process GO:0000956
The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells.
1 P17225 (/ISO)
MRNA processing GO:0006397
Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
1 P17225 (/ISO)
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
1 P17225 (/ISO)
Positive regulation of insulin secretion GO:0032024
Any process that activates or increases the frequency, rate or extent of the regulated release of insulin.
1 P17225 (/ISO)
Negative regulation of RNA splicing GO:0033119
Any process that stops, prevents, or reduces the frequency, rate or extent of RNA splicing.
1 P17225 (/ISO)
Positive regulation of protein dephosphorylation GO:0035307
Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a protein.
1 P17225 (/ISO)
Negative regulation of neuron differentiation GO:0045665
Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation.
1 P17225 (/IDA)
Positive regulation of translation GO:0045727
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
1 P17225 (/ISO)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 P17225 (/IGI)
Negative regulation of mRNA splicing, via spliceosome GO:0048025
Any process that stops, prevents or reduces the rate or extent of mRNA splicing via a spliceosomal mechanism.
1 P17225 (/IDA)
Negative regulation of mRNA splicing, via spliceosome GO:0048025
Any process that stops, prevents or reduces the rate or extent of mRNA splicing via a spliceosomal mechanism.
1 P17225 (/IMP)
Negative regulation of mRNA splicing, via spliceosome GO:0048025
Any process that stops, prevents or reduces the rate or extent of mRNA splicing via a spliceosomal mechanism.
1 P17225 (/ISO)
Negative regulation of mRNA splicing, via spliceosome GO:0048025
Any process that stops, prevents or reduces the rate or extent of mRNA splicing via a spliceosomal mechanism.
1 P17225 (/ISS)
Negative regulation of muscle cell differentiation GO:0051148
Any process that stops, prevents, or reduces the frequency, rate or extent of muscle cell differentiation.
1 P17225 (/ISO)
Negative regulation of muscle cell differentiation GO:0051148
Any process that stops, prevents, or reduces the frequency, rate or extent of muscle cell differentiation.
1 P17225 (/ISS)
Positive regulation of calcineurin-NFAT signaling cascade GO:0070886
Any process that activates or increases the frequency, rate or extent of signaling via the calcineurin-NFAT signaling cascade.
1 P17225 (/ISO)
3'-UTR-mediated mRNA stabilization GO:0070935
An mRNA stabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA.
1 P17225 (/ISO)
IRES-dependent viral translational initiation GO:0075522
Process by which viral mRNA translation is initiated, where a domain in the 5' untranslated region (UTR) of the viral mRNA called an internal ribosome entry site (IRES) binds the host 43S preinitiation complex, circumventing regular cap-dependent translation initiation.
1 P17225 (/ISO)
Positive regulation of secretory granule organization GO:1904411
Any process that activates or increases the frequency, rate or extent of secretory granule organization.
1 P17225 (/ISO)

There are 8 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
12 A0A0B4K6P4 (/HDA) A0A0B4K6W9 (/HDA) A0A0B4LHY1 (/HDA) A8JRI1 (/HDA) E1JJ45 (/HDA) Q3T7F7 (/HDA) Q7KES3 (/HDA) Q7KRS7 (/HDA) Q8IMF8 (/HDA) Q8T0H5 (/HDA)
(2 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
12 A0A0B4K6P4 (/IDA) A0A0B4K6W9 (/IDA) A0A0B4LHY1 (/IDA) A8JRI1 (/IDA) E1JJ45 (/IDA) Q3T7F7 (/IDA) Q7KES3 (/IDA) Q7KRS7 (/IDA) Q8IMF8 (/IDA) Q8T0H5 (/IDA)
(2 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
12 A0A0B4K6P4 (/HDA) A0A0B4K6W9 (/HDA) A0A0B4LHY1 (/HDA) A8JRI1 (/HDA) E1JJ45 (/HDA) Q3T7F7 (/HDA) Q7KES3 (/HDA) Q7KRS7 (/HDA) Q8IMF8 (/HDA) Q8T0H5 (/HDA)
(2 more)
Ribonucleoprotein complex GO:1990904
A macromolecular complex containing both protein and RNA molecules.
12 A0A0B4K6P4 (/IDA) A0A0B4K6W9 (/IDA) A0A0B4LHY1 (/IDA) A8JRI1 (/IDA) E1JJ45 (/IDA) Q3T7F7 (/IDA) Q7KES3 (/IDA) Q7KRS7 (/IDA) Q8IMF8 (/IDA) Q8T0H5 (/IDA)
(2 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P17225 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P17225 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P17225 (/ISO)
Neuron projection terminus GO:0044306
The specialized, terminal region of a neuron projection such as an axon or a dendrite.
1 P17225 (/ISO)