The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Dystroglycan, domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 2: Dystroglycan, isoform B

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 2 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 A0A0C4DHF6 (/IPI) A1ZA89 (/IPI) Q8STB9 (/IPI) Q8WR08 (/IPI) Q8WR09 (/IPI)
Structural constituent of muscle GO:0008307
The action of a molecule that contributes to the structural integrity of a muscle fiber.
5 A0A0C4DHF6 (/ISS) A1ZA89 (/ISS) Q8STB9 (/ISS) Q8WR08 (/ISS) Q8WR09 (/ISS)

There are 19 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of glycolytic process GO:0006110
Any process that modulates the frequency, rate or extent of glycolysis.
5 A0A0C4DHF6 (/IGI) A1ZA89 (/IGI) Q8STB9 (/IGI) Q8WR08 (/IGI) Q8WR09 (/IGI)
Cytoskeletal anchoring at plasma membrane GO:0007016
A cytoskeleton organization process that directly or indirectly links cytoskeletal filaments to the plasma membrane.
5 A0A0C4DHF6 (/ISS) A1ZA89 (/ISS) Q8STB9 (/ISS) Q8WR08 (/ISS) Q8WR09 (/ISS)
Establishment or maintenance of cell polarity GO:0007163
Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.
5 A0A0C4DHF6 (/IMP) A1ZA89 (/IMP) Q8STB9 (/IMP) Q8WR08 (/IMP) Q8WR09 (/IMP)
Germarium-derived egg chamber formation GO:0007293
Construction of a stage-1 egg chamber in the anterior part of the germarium, from the progeny of germ-line and somatic stem cells. An example of this is found in Drosophila melanogaster.
5 A0A0C4DHF6 (/IMP) A1ZA89 (/IMP) Q8STB9 (/IMP) Q8WR08 (/IMP) Q8WR09 (/IMP)
Growth of a germarium-derived egg chamber GO:0007295
Growth of the egg chamber between the time it leaves the germarium and the onset of vitellogenesis. During this time both nurse cells and the oocyte undergo developmental changes including nuclear organization and cytoplasmic growth. An example of this is found in Drosophila melanogaster.
5 A0A0C4DHF6 (/IMP) A1ZA89 (/IMP) Q8STB9 (/IMP) Q8WR08 (/IMP) Q8WR09 (/IMP)
Oocyte axis specification GO:0007309
The establishment, maintenance and elaboration of an axis in the oocyte. An example of this is found in Drosophila melanogaster.
5 A0A0C4DHF6 (/IMP) A1ZA89 (/IMP) Q8STB9 (/IMP) Q8WR08 (/IMP) Q8WR09 (/IMP)
Oocyte anterior/posterior axis specification GO:0007314
Polarization of the oocyte along its anterior-posterior axis. An example of this is found in Drosophila melanogaster.
5 A0A0C4DHF6 (/IMP) A1ZA89 (/IMP) Q8STB9 (/IMP) Q8WR08 (/IMP) Q8WR09 (/IMP)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
5 A0A0C4DHF6 (/IGI) A1ZA89 (/IGI) Q8STB9 (/IGI) Q8WR08 (/IGI) Q8WR09 (/IGI)
Imaginal disc-derived wing vein specification GO:0007474
The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified.
5 A0A0C4DHF6 (/IMP) A1ZA89 (/IMP) Q8STB9 (/IMP) Q8WR08 (/IMP) Q8WR09 (/IMP)
Muscle attachment GO:0016203
The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall).
5 A0A0C4DHF6 (/IMP) A1ZA89 (/IMP) Q8STB9 (/IMP) Q8WR08 (/IMP) Q8WR09 (/IMP)
Establishment or maintenance of polarity of follicular epithelium GO:0016334
Any cellular process that results in the specification, formation or maintenance of a polarized follicular epithelial sheet.
5 A0A0C4DHF6 (/IMP) A1ZA89 (/IMP) Q8STB9 (/IMP) Q8WR08 (/IMP) Q8WR09 (/IMP)
Establishment of cell polarity GO:0030010
The specification and formation of anisotropic intracellular organization or cell growth patterns.
5 A0A0C4DHF6 (/IMP) A1ZA89 (/IMP) Q8STB9 (/IMP) Q8WR08 (/IMP) Q8WR09 (/IMP)
Actin cytoskeleton reorganization GO:0031532
A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins.
5 A0A0C4DHF6 (/IMP) A1ZA89 (/IMP) Q8STB9 (/IMP) Q8WR08 (/IMP) Q8WR09 (/IMP)
Establishment or maintenance of apical/basal cell polarity GO:0035088
Any cellular process that results in the specification, formation or maintenance polarization of a cell's architecture along its apical/basal axis so that the apical and basal regions of the cell have different membrane, extracellular matrix and sub-membrane cellular components.
5 A0A0C4DHF6 (/IMP) A1ZA89 (/IMP) Q8STB9 (/IMP) Q8WR08 (/IMP) Q8WR09 (/IMP)
Establishment or maintenance of epithelial cell apical/basal polarity GO:0045197
Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell.
5 A0A0C4DHF6 (/IMP) A1ZA89 (/IMP) Q8STB9 (/IMP) Q8WR08 (/IMP) Q8WR09 (/IMP)
Sarcomere organization GO:0045214
The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
5 A0A0C4DHF6 (/IMP) A1ZA89 (/IMP) Q8STB9 (/IMP) Q8WR08 (/IMP) Q8WR09 (/IMP)
Muscle cell cellular homeostasis GO:0046716
The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state.
5 A0A0C4DHF6 (/IMP) A1ZA89 (/IMP) Q8STB9 (/IMP) Q8WR08 (/IMP) Q8WR09 (/IMP)
Regulation of synaptic activity GO:0060025
Any process that modulates the frequency, rate or extent of synaptic activity, the controlled release of neurotransmitters into the synaptic cleft and their subsequent detection by a postsynaptic cell.
5 A0A0C4DHF6 (/IMP) A1ZA89 (/IMP) Q8STB9 (/IMP) Q8WR08 (/IMP) Q8WR09 (/IMP)
Regulation of production of miRNAs involved in gene silencing by miRNA GO:1903798
Any process that modulates the frequency, rate or extent of production of miRNAs involved in gene silencing by miRNA.
5 A0A0C4DHF6 (/IDA) A1ZA89 (/IDA) Q8STB9 (/IDA) Q8WR08 (/IDA) Q8WR09 (/IDA)

There are 10 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
5 A0A0C4DHF6 (/HDA) A1ZA89 (/HDA) Q8STB9 (/HDA) Q8WR08 (/HDA) Q8WR09 (/HDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
5 A0A0C4DHF6 (/IDA) A1ZA89 (/IDA) Q8STB9 (/IDA) Q8WR08 (/IDA) Q8WR09 (/IDA)
Basal plasma membrane GO:0009925
The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
5 A0A0C4DHF6 (/IDA) A1ZA89 (/IDA) Q8STB9 (/IDA) Q8WR08 (/IDA) Q8WR09 (/IDA)
Dystrophin-associated glycoprotein complex GO:0016010
A multiprotein complex that forms a strong mechanical link between the cytoskeleton and extracellular matrix; typical of, but not confined to, muscle cells. The complex is composed of transmembrane, cytoplasmic, and extracellular proteins, including dystrophin, sarcoglycans, dystroglycan, dystrobrevins, syntrophins, sarcospan, caveolin-3, and NO synthase.
5 A0A0C4DHF6 (/IPI) A1ZA89 (/IPI) Q8STB9 (/IPI) Q8WR08 (/IPI) Q8WR09 (/IPI)
Dystroglycan complex GO:0016011
A protein complex that includes alpha- and beta-dystroglycan, which are alternative products of the same gene; the laminin-binding component of the dystrophin-associated glycoprotein complex, providing a link between the subsarcolemmal cytoskeleton (in muscle cells) and the extracellular matrix. Alpha-dystroglycan is an extracellular protein binding to alpha-laminin and to beta-dystroglycan; beta-dystroglycan is a transmembrane protein which binds alpha-dystroglycan and dystrophin.
5 A0A0C4DHF6 (/IDA) A1ZA89 (/IDA) Q8STB9 (/IDA) Q8WR08 (/IDA) Q8WR09 (/IDA)
Dystroglycan complex GO:0016011
A protein complex that includes alpha- and beta-dystroglycan, which are alternative products of the same gene; the laminin-binding component of the dystrophin-associated glycoprotein complex, providing a link between the subsarcolemmal cytoskeleton (in muscle cells) and the extracellular matrix. Alpha-dystroglycan is an extracellular protein binding to alpha-laminin and to beta-dystroglycan; beta-dystroglycan is a transmembrane protein which binds alpha-dystroglycan and dystrophin.
5 A0A0C4DHF6 (/ISS) A1ZA89 (/ISS) Q8STB9 (/ISS) Q8WR08 (/ISS) Q8WR09 (/ISS)
Z disc GO:0030018
Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.
5 A0A0C4DHF6 (/IDA) A1ZA89 (/IDA) Q8STB9 (/IDA) Q8WR08 (/IDA) Q8WR09 (/IDA)
T-tubule GO:0030315
Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane.
5 A0A0C4DHF6 (/IDA) A1ZA89 (/IDA) Q8STB9 (/IDA) Q8WR08 (/IDA) Q8WR09 (/IDA)
Neuromuscular junction GO:0031594
The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
5 A0A0C4DHF6 (/IDA) A1ZA89 (/IDA) Q8STB9 (/IDA) Q8WR08 (/IDA) Q8WR09 (/IDA)
Sarcolemma GO:0042383
The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.
5 A0A0C4DHF6 (/IDA) A1ZA89 (/IDA) Q8STB9 (/IDA) Q8WR08 (/IDA) Q8WR09 (/IDA)