The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Translation elongation factor EF1B, gamma chain, conserved domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Elongation factor 1-gamma 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 13 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Guanyl-nucleotide exchange factor activity GO:0005085
Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
14 P29547 (/IDA) P29547 (/IDA) P29547 (/IDA) P29547 (/IDA) P29547 (/IDA) P29547 (/IDA) P29547 (/IDA) P29547 (/IDA) P29547 (/IDA) P29547 (/IDA)
(4 more)
Core promoter binding GO:0001047
Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for the basal transcription machinery. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
10 P29547 (/IDA) P29547 (/IDA) P29547 (/IDA) P29547 (/IDA) P29547 (/IDA) P29547 (/IDA) P29547 (/IDA) P29547 (/IDA) P29547 (/IDA) P29547 (/IDA)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
10 P29547 (/IMP) P29547 (/IMP) P29547 (/IMP) P29547 (/IMP) P29547 (/IMP) P29547 (/IMP) P29547 (/IMP) P29547 (/IMP) P29547 (/IMP) P29547 (/IMP)
Translation elongation factor activity GO:0003746
Functions in chain elongation during polypeptide synthesis at the ribosome.
10 Q8IDV0 (/ISS) Q8IDV0 (/ISS) Q8IDV0 (/ISS) Q8IDV0 (/ISS) Q8IDV0 (/ISS) Q8IDV0 (/ISS) Q8IDV0 (/ISS) Q8IDV0 (/ISS) Q9NJH0 (/ISS) Q9NJH0 (/ISS)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
10 P29547 (/IDA) P29547 (/IDA) P29547 (/IDA) P29547 (/IDA) P29547 (/IDA) P29547 (/IDA) P29547 (/IDA) P29547 (/IDA) P29547 (/IDA) P29547 (/IDA)
Phospholipid binding GO:0005543
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester.
10 P29547 (/IDA) P29547 (/IDA) P29547 (/IDA) P29547 (/IDA) P29547 (/IDA) P29547 (/IDA) P29547 (/IDA) P29547 (/IDA) P29547 (/IDA) P29547 (/IDA)
Glutathione transferase activity GO:0004364
Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group.
8 Q8IDV0 (/ISS) Q8IDV0 (/ISS) Q8IDV0 (/ISS) Q8IDV0 (/ISS) Q8IDV0 (/ISS) Q8IDV0 (/ISS) Q8IDV0 (/ISS) Q8IDV0 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
8 P26641 (/IPI) P26641 (/IPI) P26641 (/IPI) P26641 (/IPI) P36008 (/IPI) P36008 (/IPI) P36008 (/IPI) P36008 (/IPI)
Translation elongation factor activity GO:0003746
Functions in chain elongation during polypeptide synthesis at the ribosome.
4 P36008 (/TAS) P36008 (/TAS) P36008 (/TAS) P36008 (/TAS)
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
4 P26641 (/HDA) P26641 (/HDA) P26641 (/HDA) P26641 (/HDA)
Translation elongation factor activity GO:0003746
Functions in chain elongation during polypeptide synthesis at the ribosome.
2 Q382L7 (/ISM) Q382M7 (/ISM)
Copper ion binding GO:0005507
Interacting selectively and non-covalently with copper (Cu) ions.
2 Q9FVT2 (/IDA) Q9FVT2 (/IDA)
Translation elongation factor activity GO:0003746
Functions in chain elongation during polypeptide synthesis at the ribosome.
1 P40921 (/ISO)

There are 11 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Translational elongation GO:0006414
The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis.
14 P29547 (/IDA) P29547 (/IDA) P29547 (/IDA) P29547 (/IDA) P29547 (/IDA) P29547 (/IDA) P29547 (/IDA) P29547 (/IDA) P29547 (/IDA) P29547 (/IDA)
(4 more)
Translational elongation GO:0006414
The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis.
10 Q8IDV0 (/ISS) Q8IDV0 (/ISS) Q8IDV0 (/ISS) Q8IDV0 (/ISS) Q8IDV0 (/ISS) Q8IDV0 (/ISS) Q8IDV0 (/ISS) Q8IDV0 (/ISS) Q9NJH0 (/ISS) Q9NJH0 (/ISS)
Regulation of translational termination GO:0006449
Any process that modulates the frequency, rate or extent of translational termination.
10 P29547 (/IGI) P29547 (/IGI) P29547 (/IGI) P29547 (/IGI) P29547 (/IGI) P29547 (/IGI) P29547 (/IGI) P29547 (/IGI) P29547 (/IGI) P29547 (/IGI)
Ribosome biogenesis GO:0042254
A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis.
10 P29547 (/IGI) P29547 (/IGI) P29547 (/IGI) P29547 (/IGI) P29547 (/IGI) P29547 (/IGI) P29547 (/IGI) P29547 (/IGI) P29547 (/IGI) P29547 (/IGI)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
10 P29547 (/IMP) P29547 (/IMP) P29547 (/IMP) P29547 (/IMP) P29547 (/IMP) P29547 (/IMP) P29547 (/IMP) P29547 (/IMP) P29547 (/IMP) P29547 (/IMP)
Translational elongation GO:0006414
The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis.
4 P26641 (/TAS) P26641 (/TAS) P26641 (/TAS) P26641 (/TAS)
Response to virus GO:0009615
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
4 P26641 (/IEP) P26641 (/IEP) P26641 (/IEP) P26641 (/IEP)
Translational elongation GO:0006414
The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis.
2 Q382L7 (/ISM) Q382M7 (/ISM)
Response to zinc ion GO:0010043
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus.
2 Q9FVT2 (/IEP) Q9FVT2 (/IEP)
Response to cadmium ion GO:0046686
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
2 Q9FVT2 (/IEP) Q9FVT2 (/IEP)
Cytoplasmic translational elongation GO:0002182
The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in the cytoplasm.
1 P40921 (/IDA)

There are 23 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Eukaryotic translation elongation factor 1 complex GO:0005853
A multisubunit nucleotide exchange complex that binds GTP and aminoacyl-tRNAs, and catalyzes their codon-dependent placement at the A-site of the ribosome. In humans, the complex is composed of four subunits, alpha, beta, delta and gamma.
14 P36008 (/ISS) P36008 (/ISS) P36008 (/ISS) P36008 (/ISS) Q8IDV0 (/ISS) Q8IDV0 (/ISS) Q8IDV0 (/ISS) Q8IDV0 (/ISS) Q8IDV0 (/ISS) Q8IDV0 (/ISS)
(4 more)
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
14 P29547 (/IDA) P29547 (/IDA) P29547 (/IDA) P29547 (/IDA) P29547 (/IDA) P29547 (/IDA) P29547 (/IDA) P29547 (/IDA) P29547 (/IDA) P29547 (/IDA)
(4 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
12 P29547 (/IDA) P29547 (/IDA) P29547 (/IDA) P29547 (/IDA) P29547 (/IDA) P29547 (/IDA) P29547 (/IDA) P29547 (/IDA) P29547 (/IDA) P29547 (/IDA)
(2 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
6 P26641 (/IDA) P26641 (/IDA) P26641 (/IDA) P26641 (/IDA) Q9NJH0 (/IDA) Q9NJH0 (/IDA)
Vacuole GO:0005773
A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.
5 O04487 (/IDA) O04487 (/IDA) O04487 (/IDA) Q9FVT2 (/IDA) Q9FVT2 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
5 O04487 (/IDA) O04487 (/IDA) O04487 (/IDA) Q9FVT2 (/IDA) Q9FVT2 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
5 O04487 (/IDA) O04487 (/IDA) O04487 (/IDA) Q9FVT2 (/IDA) Q9FVT2 (/IDA)
Plasmodesma GO:0009506
A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell.
5 O04487 (/IDA) O04487 (/IDA) O04487 (/IDA) Q9FVT2 (/IDA) Q9FVT2 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
4 P26641 (/HDA) P26641 (/HDA) P26641 (/HDA) P26641 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
4 P36008 (/HDA) P36008 (/HDA) P36008 (/HDA) P36008 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 P26641 (/TAS) P26641 (/TAS) P26641 (/TAS) P26641 (/TAS)
Ribosome GO:0005840
An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.
4 P36008 (/TAS) P36008 (/TAS) P36008 (/TAS) P36008 (/TAS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
4 P26641 (/HDA) P26641 (/HDA) P26641 (/HDA) P26641 (/HDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
4 P26641 (/HDA) P26641 (/HDA) P26641 (/HDA) P26641 (/HDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
2 Q5AYR7 (/IDA) Q5AYR7 (/IDA)
Cell wall GO:0005618
The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
2 Q9FVT2 (/IDA) Q9FVT2 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q9D8N0 (/ISO) Q9D8N0 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 Q9FVT2 (/IDA) Q9FVT2 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P40921 (/HDA)
Eukaryotic translation elongation factor 1 complex GO:0005853
A multisubunit nucleotide exchange complex that binds GTP and aminoacyl-tRNAs, and catalyzes their codon-dependent placement at the A-site of the ribosome. In humans, the complex is composed of four subunits, alpha, beta, delta and gamma.
1 Q382L7 (/ISA)
Eukaryotic translation elongation factor 1 complex GO:0005853
A multisubunit nucleotide exchange complex that binds GTP and aminoacyl-tRNAs, and catalyzes their codon-dependent placement at the A-site of the ribosome. In humans, the complex is composed of four subunits, alpha, beta, delta and gamma.
1 Q382M7 (/ISM)
Extracellular matrix GO:0031012
A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.
1 B0G141 (/HDA)
Phagocytic vesicle GO:0045335
A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis.
1 B0G141 (/HDA)