The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 11: reversion-inducing cysteine-rich protein with Kaza...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Metalloendopeptidase inhibitor activity GO:0008191
Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity.
3 A0A0R4IKU3 (/ISS) A0A1D5PUP4 (/ISS) Q9Z0J1 (/ISS)
Endopeptidase inhibitor activity GO:0004866
Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides.
2 O95980 (/IDA) Q9Z0J1 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 O95980 (/IPI) Q9Z0J1 (/IPI)
Coreceptor activity involved in canonical Wnt signaling pathway GO:1904928
Any coreceptor activity that is involved in a canonical Wnt signaling pathway.
2 A0A0R4IKU3 (/ISS) A0A1D5PUP4 (/ISS)
Endopeptidase inhibitor activity GO:0004866
Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides.
1 Q9Z0J1 (/ISO)
Metalloendopeptidase inhibitor activity GO:0008191
Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity.
1 O95980 (/IDA)
Metalloendopeptidase inhibitor activity GO:0008191
Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity.
1 Q9Z0J1 (/ISO)
Metalloendopeptidase inhibitor activity GO:0008191
Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity.
1 O95980 (/TAS)
Wnt-protein binding GO:0017147
Interacting selectively and non-covalently with Wnt-protein, a secreted growth factor involved in signaling.
1 Q9Z0J1 (/IPI)
Coreceptor activity involved in canonical Wnt signaling pathway GO:1904928
Any coreceptor activity that is involved in a canonical Wnt signaling pathway.
1 Q9Z0J1 (/IDA)

There are 23 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of metalloendopeptidase activity GO:1904684
Any process that stops, prevents or reduces the frequency, rate or extent of metalloendopeptidase activity.
4 A0A0R4IKU3 (/ISS) A0A1D5PUP4 (/ISS) O95980 (/ISS) Q9Z0J1 (/ISS)
Regulation of angiogenesis GO:0045765
Any process that modulates the frequency, rate or extent of angiogenesis.
2 A0A0R4IKU3 (/ISS) A0A1D5PUP4 (/ISS)
Regulation of establishment of blood-brain barrier GO:0090210
Any process that modulates the rate, frequency or extent of the establishment of the blood-brain barrier, a selectively permeable structural and functional barrier that exists between the capillaries and the brain.
2 A0A0R4IKU3 (/ISS) A0A1D5PUP4 (/ISS)
Positive regulation of canonical Wnt signaling pathway GO:0090263
Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
2 A0A0R4IKU3 (/ISS) A0A1D5PUP4 (/ISS)
Vasculature development GO:0001944
The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism.
1 A0A0R4IKU3 (/IMP)
Blood vessel maturation GO:0001955
A developmental process, independent of morphogenetic (shape) change, that is required for a blood vessel to attain its fully functional state.
1 Q9Z0J1 (/IGI)
Blood vessel maturation GO:0001955
A developmental process, independent of morphogenetic (shape) change, that is required for a blood vessel to attain its fully functional state.
1 Q9Z0J1 (/IMP)
Sprouting angiogenesis GO:0002040
The extension of new blood vessels from existing vessels into avascular tissues, this process includes the specialization of endothelial cells into leading tip and stalk cells, proliferation and migration of the endothelial cells and cell adhesion resulting in angiogenic sprout fusion or lumen formation.
1 A0A0R4IKU3 (/IMP)
Embryo implantation GO:0007566
Attachment of the blastocyst to the uterine lining.
1 Q9Z0J1 (/IDA)
Wnt signaling pathway GO:0016055
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.
1 A0A0R4IKU3 (/IMP)
Extracellular matrix organization GO:0030198
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.
1 Q9Z0J1 (/IMP)
Negative regulation of cell migration GO:0030336
Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
1 O95980 (/IMP)
Negative regulation of cell migration GO:0030336
Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
1 Q9Z0J1 (/ISO)
Embryonic forelimb morphogenesis GO:0035115
The process, occurring in the embryo, by which the anatomical structures of the forelimb are generated and organized. The forelimbs are the front limbs of an animal, e.g. the arms of a human.
1 Q9Z0J1 (/IMP)
Regulation of angiogenesis GO:0045765
Any process that modulates the frequency, rate or extent of angiogenesis.
1 Q9Z0J1 (/IMP)
Regulation of canonical Wnt signaling pathway GO:0060828
Any process that modulates the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
1 A0A0R4IKU3 (/IMP)
Regulation of cell migration involved in sprouting angiogenesis GO:0090049
Any process that modulates the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis.
1 A0A0R4IKU3 (/IMP)
Regulation of establishment of blood-brain barrier GO:0090210
Any process that modulates the rate, frequency or extent of the establishment of the blood-brain barrier, a selectively permeable structural and functional barrier that exists between the capillaries and the brain.
1 Q9Z0J1 (/IMP)
Positive regulation of canonical Wnt signaling pathway GO:0090263
Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
1 Q9Z0J1 (/IDA)
Negative regulation of metalloendopeptidase activity GO:1904684
Any process that stops, prevents or reduces the frequency, rate or extent of metalloendopeptidase activity.
1 O95980 (/IDA)
Negative regulation of metalloendopeptidase activity GO:1904684
Any process that stops, prevents or reduces the frequency, rate or extent of metalloendopeptidase activity.
1 Q9Z0J1 (/IMP)
Negative regulation of metalloendopeptidase activity GO:1904684
Any process that stops, prevents or reduces the frequency, rate or extent of metalloendopeptidase activity.
1 Q9Z0J1 (/ISO)
Dorsal root ganglion development GO:1990791
The process whose specific outcome is the progression of a dorsal root ganglion over time, from its formation to the mature structure.
1 A0A0R4IKU3 (/IMP)

There are 8 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 A0A0R4IKU3 (/IDA) O95980 (/IDA) Q9Z0J1 (/IDA)
Wnt signalosome GO:1990909
A multiprotein protein complex containing membrane-localized Wnt receptors and cytosolic protein complexes, which is capable of transmitting the Wnt signal. Contains at least a Wnt protein, LRP5 or LRP6, a member of the Frizzled (Fz) family, Axin and and a Dishevelled (DVL) protein.
2 A0A0R4IKU3 (/ISS) A0A1D5PUP4 (/ISS)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 O95980 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q9Z0J1 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 A0A1D5PUP4 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 O95980 (/TAS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 O95980 (/TAS)
Wnt signalosome GO:1990909
A multiprotein protein complex containing membrane-localized Wnt receptors and cytosolic protein complexes, which is capable of transmitting the Wnt signal. Contains at least a Wnt protein, LRP5 or LRP6, a member of the Frizzled (Fz) family, Axin and and a Dishevelled (DVL) protein.
1 Q9Z0J1 (/IDA)