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CATH Superfamily 3.30.60.210

Stc1 domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Stc1 domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Stc1 domain

This superfamily contains the Stc1 domain, which contains 8 conserved cysteine residues that may bind to zinc. In S. pombe this protein acts as a protein linker which links the chromatin modifying CLRC complex to RNAi by tethering it to the RITS complex. The region is reported as a LIM domain here, but has a slightly different arrangement of its CxxC pairs from the Pfam LIM domain PFAM:PF00412, distinguished by a lack of preferred relative orientation of the two zinc fingers. PMID:20211136,PMID:23613586. The tandem zinc-finger structure is involved in binding Ago1, whereas the nonconserved C-terminal region mediates association with CLRC.

INTERPRO:IPR024630, PFAM:PF12898,DOI:10.1073/pnas.1212155110

GO Diversity

Unique GO annotations
12 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
19 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 1
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 1
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 1
Function
Unique EC:
Unique GO: 12
Taxonomy
Unique Species: 19