The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Glutamine synthetase/guanido kinase, catalytic domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4: Glutamine synthetase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 8 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Glutamate-ammonia ligase activity GO:0004356
Catalysis of the reaction: L-glutamate + ATP + NH(3) = L-glutamine + ADP + 2 H(+) + phosphate.
33 A8WCU3 (/IDA) A8WCU3 (/IDA) A8WCU3 (/IDA) A8WCU4 (/IDA) A8WCU4 (/IDA) A8WCU4 (/IDA) A8WCU5 (/IDA) A8WCU6 (/IDA) A8WCU7 (/IDA) A8WCU8 (/IDA)
(23 more)
Glutamate-ammonia ligase activity GO:0004356
Catalysis of the reaction: L-glutamate + ATP + NH(3) = L-glutamine + ADP + 2 H(+) + phosphate.
10 P32288 (/IMP) P32288 (/IMP) P32288 (/IMP) P32288 (/IMP) P32288 (/IMP) P32288 (/IMP) P32288 (/IMP) P32288 (/IMP) P32288 (/IMP) Q09179 (/IMP)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 Q56WN1 (/IPI) Q8LCE1 (/IPI) Q8LCE1 (/IPI) Q9FMD9 (/IPI) Q9FMD9 (/IPI)
Copper ion binding GO:0005507
Interacting selectively and non-covalently with copper (Cu) ions.
4 F4ID91 (/IDA) Q56WN1 (/IDA) Q9LVI8 (/IDA) Q9LVI8 (/IDA)
Glutamate-ammonia ligase activity GO:0004356
Catalysis of the reaction: L-glutamate + ATP + NH(3) = L-glutamine + ADP + 2 H(+) + phosphate.
3 Q43127 (/TAS) Q43127 (/TAS) Q43127 (/TAS)
Structural constituent of ribosome GO:0003735
The action of a molecule that contributes to the structural integrity of the ribosome.
2 Q9LVI8 (/IDA) Q9LVI8 (/IDA)
Glutamate-ammonia ligase activity GO:0004356
Catalysis of the reaction: L-glutamate + ATP + NH(3) = L-glutamine + ADP + 2 H(+) + phosphate.
2 P04773 (/ISS) P46410 (/ISS)
Protein-cysteine S-palmitoyltransferase activity GO:0019706
Catalysis of the transfer of a palmitoyl group to a sulfur atom on the cysteine of a protein molecule.
2 P04773 (/ISS) P46410 (/ISS)

There are 20 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Glutamine biosynthetic process GO:0006542
The chemical reactions and pathways resulting in the formation of glutamine, 2-amino-4-carbamoylbutanoic acid.
10 P32288 (/IDA) P32288 (/IDA) P32288 (/IDA) P32288 (/IDA) P32288 (/IDA) P32288 (/IDA) P32288 (/IDA) P32288 (/IDA) P32288 (/IDA) Q09179 (/IDA)
Seed trichome elongation GO:0090378
The process in which a seed trichome irreversibly increases in size in one
10 A8WCU3 (/IEP) A8WCU3 (/IEP) A8WCU3 (/IEP) A8WCU4 (/IEP) A8WCU4 (/IEP) A8WCU4 (/IEP) A8WCU5 (/IEP) A8WCU6 (/IEP) A8WCU7 (/IEP) A8WCU8 (/IEP)
Nitrate assimilation GO:0042128
The nitrogen metabolic process that encompasses the uptake of nitrate from the environment and reduction to ammonia, and results in the incorporation of nitrogen derived from nitrate into cellular substances.
6 F4ID91 (/TAS) Q56WN1 (/TAS) Q9FMD9 (/TAS) Q9FMD9 (/TAS) Q9LVI8 (/TAS) Q9LVI8 (/TAS)
Response to cadmium ion GO:0046686
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
5 Q43127 (/IEP) Q43127 (/IEP) Q43127 (/IEP) Q9LVI8 (/IEP) Q9LVI8 (/IEP)
Response to salt stress GO:0009651
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
4 F4ID91 (/IEP) Q43127 (/IEP) Q43127 (/IEP) Q43127 (/IEP)
Response to food GO:0032094
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a food stimulus; food is anything which, when taken into the body, serves to nourish or build up the tissues or to supply body heat.
4 Q8JI31 (/IDA) Q8JI32 (/IDA) Q8JI33 (/IDA) Q8JI34 (/IDA)
Aging GO:0007568
A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
3 Q43127 (/TAS) Q43127 (/TAS) Q43127 (/TAS)
Response to cytokinin GO:0009735
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokinin stimulus.
3 Q43127 (/IDA) Q43127 (/IDA) Q43127 (/IDA)
Ammonia assimilation cycle GO:0019676
The pathway by which ammonia is processed and incorporated into a cell. In an energy-rich (glucose-containing), nitrogen-poor environment, glutamine synthetase and glutamate synthase form an ammonia assimilatory cycle, in which ammonia is incorporated into L-glutamate to form L-glutamine, which then combines with alpha-ketoglutarate to regenerate L-glutamate. This ATP-dependent cycle is essential for nitrogen-limited growth and for steady-state growth with some sources of nitrogen.
3 Q43127 (/TAS) Q43127 (/TAS) Q43127 (/TAS)
Glutamine metabolic process GO:0006541
The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid.
2 P20477 (/IGI) P20477 (/IGI)
Glutamine metabolic process GO:0006541
The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid.
2 P20477 (/IMP) P20477 (/IMP)
Phagocytosis GO:0006909
A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
2 P20477 (/IMP) P20477 (/IMP)
Mitochondrion organization GO:0007005
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.
2 P20477 (/IGI) P20477 (/IGI)
Mitochondrion organization GO:0007005
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.
2 P20477 (/IMP) P20477 (/IMP)
Regulation of endothelial cell migration GO:0010594
Any process that modulates the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
2 P04773 (/ISS) P46410 (/ISS)
Protein palmitoylation GO:0018345
The covalent attachment of a palmitoyl group to a protein.
2 P04773 (/ISS) P46410 (/ISS)
Regulation of sprouting angiogenesis GO:1903670
Any process that modulates the frequency, rate or extent of sprouting angiogenesis.
2 P04773 (/ISS) P46410 (/ISS)
Glutamine biosynthetic process GO:0006542
The chemical reactions and pathways resulting in the formation of glutamine, 2-amino-4-carbamoylbutanoic acid.
1 Q09179 (/IMP)
Leaf senescence GO:0010150
The process that occurs in a leaf near the end of its active life that is associated with the dismantling of cell components and membranes, loss of functional chloroplasts, and an overall decline in metabolism.
1 Q56WN1 (/IEP)
Ammonia assimilation cycle GO:0019676
The pathway by which ammonia is processed and incorporated into a cell. In an energy-rich (glucose-containing), nitrogen-poor environment, glutamine synthetase and glutamate synthase form an ammonia assimilatory cycle, in which ammonia is incorporated into L-glutamate to form L-glutamine, which then combines with alpha-ketoglutarate to regenerate L-glutamate. This ATP-dependent cycle is essential for nitrogen-limited growth and for steady-state growth with some sources of nitrogen.
1 Q09179 (/IMP)

There are 25 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
10 P32288 (/HDA) P32288 (/HDA) P32288 (/HDA) P32288 (/HDA) P32288 (/HDA) P32288 (/HDA) P32288 (/HDA) P32288 (/HDA) P32288 (/HDA) Q09179 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
9 P32288 (/HDA) P32288 (/HDA) P32288 (/HDA) P32288 (/HDA) P32288 (/HDA) P32288 (/HDA) P32288 (/HDA) P32288 (/HDA) P32288 (/HDA)
Nuclear periphery GO:0034399
The portion of the nuclear lumen proximal to the inner nuclear membrane.
9 P32288 (/IDA) P32288 (/IDA) P32288 (/IDA) P32288 (/IDA) P32288 (/IDA) P32288 (/IDA) P32288 (/IDA) P32288 (/IDA) P32288 (/IDA)
Cytosolic ribosome GO:0022626
A ribosome located in the cytosol.
7 F4ID91 (/IDA) Q43127 (/IDA) Q43127 (/IDA) Q43127 (/IDA) Q56WN1 (/IDA) Q9LVI8 (/IDA) Q9LVI8 (/IDA)
Chloroplast GO:0009507
A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
6 Q43127 (/IDA) Q43127 (/IDA) Q43127 (/IDA) Q8GXW5 (/IDA) Q9LVI8 (/IDA) Q9LVI8 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
5 P20477 (/IDA) P20477 (/IDA) Q43127 (/IDA) Q43127 (/IDA) Q43127 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 F4ID91 (/TAS) Q56WN1 (/TAS) Q9LVI8 (/TAS) Q9LVI8 (/TAS)
Chloroplast stroma GO:0009570
The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis.
4 F4ID91 (/IDA) Q43127 (/IDA) Q43127 (/IDA) Q43127 (/IDA)
Chloroplast envelope GO:0009941
The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space.
4 F4ID91 (/IDA) Q43127 (/IDA) Q43127 (/IDA) Q43127 (/IDA)
Apoplast GO:0048046
The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it.
4 F4ID91 (/IDA) Q43127 (/IDA) Q43127 (/IDA) Q43127 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 Q56WN1 (/IDA) Q9LVI8 (/IDA) Q9LVI8 (/IDA)
Chloroplast GO:0009507
A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
3 Q43127 (/NAS) Q43127 (/NAS) Q43127 (/NAS)
Chloroplast thylakoid membrane GO:0009535
The pigmented membrane of a chloroplast thylakoid. An example of this component is found in Arabidopsis thaliana.
3 Q43127 (/IDA) Q43127 (/IDA) Q43127 (/IDA)
Thylakoid GO:0009579
A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation.
3 Q43127 (/IDA) Q43127 (/IDA) Q43127 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
3 Q43127 (/IDA) Q43127 (/IDA) Q43127 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 P20477 (/HDA) P20477 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P04773 (/ISS) P46410 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q9FMD9 (/NAS) Q9FMD9 (/NAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P04773 (/ISS) P46410 (/ISS)
Plasmodesma GO:0009506
A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell.
2 Q56WN1 (/IDA) Q8GXW5 (/IDA)
Polysomal ribosome GO:0042788
A ribosome bound to mRNA that forms part of a polysome.
2 Q9LVI8 (/IDA) Q9LVI8 (/IDA)
Cell wall GO:0005618
The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
1 Q56WN1 (/IDA)
Vacuole GO:0005773
A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.
1 F4ID91 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q09179 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 F4ID91 (/IDA)