The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
SH2 domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 84: Signal transducing adaptor family member 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 13 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 Q9JM90 (/IPI) Q9ULZ2 (/IPI) Q9ULZ2 (/IPI)
Phosphotyrosine residue binding GO:0001784
Interacting selectively and non-covalently with a phosphorylated tyrosine residue within a protein.
2 Q9ULZ2 (/IPI) Q9ULZ2 (/IPI)
Transmembrane receptor protein tyrosine kinase adaptor activity GO:0005068
The binding activity of a molecule that brings together a transmembrane receptor protein tyrosine kinase and one or more other molecules, permitting them to function in a coordinated way.
2 Q9ULZ2 (/ISS) Q9ULZ2 (/ISS)
SH3/SH2 adaptor activity GO:0005070
Interacting selectively and non-covalently and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68).
2 Q9ULZ2 (/IPI) Q9ULZ2 (/IPI)
Phospholipid binding GO:0005543
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester.
2 Q9ULZ2 (/NAS) Q9ULZ2 (/NAS)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
2 Q9ULZ2 (/IPI) Q9ULZ2 (/IPI)
Phosphotyrosine residue binding GO:0001784
Interacting selectively and non-covalently with a phosphorylated tyrosine residue within a protein.
1 Q9JM90 (/ISO)
Transmembrane receptor protein tyrosine kinase adaptor activity GO:0005068
The binding activity of a molecule that brings together a transmembrane receptor protein tyrosine kinase and one or more other molecules, permitting them to function in a coordinated way.
1 Q9JM90 (/IDA)
SH3/SH2 adaptor activity GO:0005070
Interacting selectively and non-covalently and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68).
1 Q9JM90 (/IDA)
SH3/SH2 adaptor activity GO:0005070
Interacting selectively and non-covalently and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68).
1 Q9JM90 (/ISO)
Macrophage colony-stimulating factor receptor binding GO:0005157
Interacting selectively and non-covalently with the macrophage colony-stimulating factor receptor.
1 Q9JM90 (/IPI)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
1 Q9JM90 (/ISO)
Receptor tyrosine kinase binding GO:0030971
Interacting selectively and non-covalently with a receptor that possesses protein tyrosine kinase activity.
1 Q9JM90 (/IPI)

There are 29 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169
A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription.
2 Q9ULZ2 (/ISS) Q9ULZ2 (/ISS)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 Q9ULZ2 (/ISS) Q9ULZ2 (/ISS)
Negative regulation of macrophage chemotaxis GO:0010760
Any process that decreases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus.
2 Q9ULZ2 (/ISS) Q9ULZ2 (/ISS)
Negative regulation of phosphorylation GO:0042326
Any process that stops, prevents or decreases the rate of addition of phosphate groups to a molecule.
2 Q9ULZ2 (/ISS) Q9ULZ2 (/ISS)
Positive regulation of B cell receptor signaling pathway GO:0050861
Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell.
2 Q9ULZ2 (/IDA) Q9ULZ2 (/IDA)
Positive regulation of phagocytosis, engulfment GO:0060100
Any process that activates or increases the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis.
2 Q9ULZ2 (/ISS) Q9ULZ2 (/ISS)
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
2 Q9ULZ2 (/ISS) Q9ULZ2 (/ISS)
Negative regulation of ruffle assembly GO:1900028
Any process that stops, prevents or reduces the frequency, rate or extent of ruffle assembly.
2 Q9ULZ2 (/ISS) Q9ULZ2 (/ISS)
Negative regulation of macrophage colony-stimulating factor signaling pathway GO:1902227
Any process that stops, prevents or reduces the frequency, rate or extent of macrophage colony-stimulating factor signaling pathway.
2 Q9ULZ2 (/ISS) Q9ULZ2 (/ISS)
Positive regulation of microglial cell activation GO:1903980
Any process that activates or increases the frequency, rate or extent of microglial cell activation.
2 Q9ULZ2 (/ISS) Q9ULZ2 (/ISS)
Positive regulation of non-membrane spanning protein tyrosine kinase activity GO:1903997
Any process that activates or increases the frequency, rate or extent of non-membrane spanning protein tyrosine kinase activity.
2 Q9ULZ2 (/IDA) Q9ULZ2 (/IDA)
Positive regulation of microglial cell mediated cytotoxicity GO:1904151
Any process that activates or increases the frequency, rate or extent of microglial cell mediated cytotoxicity.
2 Q9ULZ2 (/ISS) Q9ULZ2 (/ISS)
Positive regulation of actin cytoskeleton reorganization GO:2000251
Any process that activates or increases the frequency, rate or extent of actin cytoskeleton reorganization.
2 Q9ULZ2 (/ISS) Q9ULZ2 (/ISS)
Transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169
A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription.
1 Q9JM90 (/IDA)
Response to bacterium GO:0009617
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.
1 Q9JM90 (/IEP)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q9JM90 (/IDA)
Negative regulation of macrophage chemotaxis GO:0010760
Any process that decreases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus.
1 Q9JM90 (/IMP)
Myeloid cell differentiation GO:0030099
The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages.
1 Q9JM90 (/TAS)
Negative regulation of phosphorylation GO:0042326
Any process that stops, prevents or decreases the rate of addition of phosphate groups to a molecule.
1 Q9JM90 (/IDA)
Positive regulation of B cell receptor signaling pathway GO:0050861
Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell.
1 Q9JM90 (/ISO)
Positive regulation of phagocytosis, engulfment GO:0060100
Any process that activates or increases the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis.
1 Q9JM90 (/IDA)
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
1 Q9JM90 (/IDA)
Negative regulation of ruffle assembly GO:1900028
Any process that stops, prevents or reduces the frequency, rate or extent of ruffle assembly.
1 Q9JM90 (/IMP)
Negative regulation of macrophage colony-stimulating factor signaling pathway GO:1902227
Any process that stops, prevents or reduces the frequency, rate or extent of macrophage colony-stimulating factor signaling pathway.
1 Q9JM90 (/IMP)
Positive regulation of microglial cell activation GO:1903980
Any process that activates or increases the frequency, rate or extent of microglial cell activation.
1 Q9JM90 (/IMP)
Positive regulation of non-membrane spanning protein tyrosine kinase activity GO:1903997
Any process that activates or increases the frequency, rate or extent of non-membrane spanning protein tyrosine kinase activity.
1 Q9JM90 (/ISO)
Negative regulation of microglial cell migration GO:1904140
Any process that stops, prevents or reduces the frequency, rate or extent of microglial cell migration.
1 Q9JM90 (/IMP)
Positive regulation of microglial cell mediated cytotoxicity GO:1904151
Any process that activates or increases the frequency, rate or extent of microglial cell mediated cytotoxicity.
1 Q9JM90 (/IDA)
Positive regulation of actin cytoskeleton reorganization GO:2000251
Any process that activates or increases the frequency, rate or extent of actin cytoskeleton reorganization.
1 Q9JM90 (/IMP)

There are 12 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
4 A0A024RD91 (/IDA) A0A024RD91 (/IDA) Q9ULZ2 (/IDA) Q9ULZ2 (/IDA)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
4 A0A024RD91 (/IDA) A0A024RD91 (/IDA) Q9ULZ2 (/IDA) Q9ULZ2 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q9ULZ2 (/IDA) Q9ULZ2 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q9ULZ2 (/IDA) Q9ULZ2 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 Q9ULZ2 (/IDA) Q9ULZ2 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
2 Q9ULZ2 (/IDA) Q9ULZ2 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9JM90 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q9JM90 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q9JM90 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q9JM90 (/ISO)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 Q9JM90 (/ISO)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
1 Q9JM90 (/ISO)