The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"SH2 domain
".
FunFam 62: SH2 domain-containing protein 1A
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 2 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
18 |
O60880 (/IPI)
O60880 (/IPI)
O60880 (/IPI)
O60880 (/IPI)
O60880 (/IPI)
O60880 (/IPI)
O60880 (/IPI)
O60880 (/IPI)
O60880 (/IPI)
O60880 (/IPI)
(8 more) |
|
SH3/SH2 adaptor activity GO:0005070
Interacting selectively and non-covalently and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68).
|
16 |
O60880 (/NAS)
O60880 (/NAS)
O60880 (/NAS)
O60880 (/NAS)
O60880 (/NAS)
O60880 (/NAS)
O60880 (/NAS)
O60880 (/NAS)
O60880 (/NAS)
O60880 (/NAS)
(6 more) |
There are 7 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cellular defense response GO:0006968
A defense response that is mediated by cells.
|
16 |
O60880 (/NAS)
O60880 (/NAS)
O60880 (/NAS)
O60880 (/NAS)
O60880 (/NAS)
O60880 (/NAS)
O60880 (/NAS)
O60880 (/NAS)
O60880 (/NAS)
O60880 (/NAS)
(6 more) |
|
Cell-cell signaling GO:0007267
Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
|
16 |
O60880 (/IDA)
O60880 (/IDA)
O60880 (/IDA)
O60880 (/IDA)
O60880 (/IDA)
O60880 (/IDA)
O60880 (/IDA)
O60880 (/IDA)
O60880 (/IDA)
O60880 (/IDA)
(6 more) |
|
Regulation of immune response GO:0050776
Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
|
16 |
O60880 (/TAS)
O60880 (/TAS)
O60880 (/TAS)
O60880 (/TAS)
O60880 (/TAS)
O60880 (/TAS)
O60880 (/TAS)
O60880 (/TAS)
O60880 (/TAS)
O60880 (/TAS)
(6 more) |
|
Humoral immune response GO:0006959
An immune response mediated through a body fluid.
|
2 | O88890 (/IMP) O88890 (/IMP) |
|
Cell-cell signaling GO:0007267
Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
|
2 | O88890 (/ISO) O88890 (/ISO) |
|
Positive regulation of natural killer cell mediated cytotoxicity GO:0045954
Any process that activates or increases the frequency, rate or extent of natural killer cell mediated cytotoxicity.
|
2 | O88890 (/IGI) O88890 (/IGI) |
|
Positive regulation of natural killer cell mediated cytotoxicity GO:0045954
Any process that activates or increases the frequency, rate or extent of natural killer cell mediated cytotoxicity.
|
2 | O88890 (/IMP) O88890 (/IMP) |
There are 3 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
16 |
O60880 (/IDA)
O60880 (/IDA)
O60880 (/IDA)
O60880 (/IDA)
O60880 (/IDA)
O60880 (/IDA)
O60880 (/IDA)
O60880 (/IDA)
O60880 (/IDA)
O60880 (/IDA)
(6 more) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
16 |
O60880 (/TAS)
O60880 (/TAS)
O60880 (/TAS)
O60880 (/TAS)
O60880 (/TAS)
O60880 (/TAS)
O60880 (/TAS)
O60880 (/TAS)
O60880 (/TAS)
O60880 (/TAS)
(6 more) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | O88890 (/ISO) O88890 (/ISO) |