The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
SH2 domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 55: Tyrosine-protein kinase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 16 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Growth hormone receptor binding GO:0005131
Interacting selectively and non-covalently with the growth hormone receptor.
2 G3V9W2 (/IPI) P52332 (/IPI)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 P23458 (/IPI) P52332 (/IPI)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
1 P23458 (/EXP)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
1 P52332 (/IDA)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
1 P52332 (/IMP)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
1 P52332 (/ISO)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
1 P23458 (/TAS)
Non-membrane spanning protein tyrosine kinase activity GO:0004715
Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein.
1 P23458 (/TAS)
Growth hormone receptor binding GO:0005131
Interacting selectively and non-covalently with the growth hormone receptor.
1 P52332 (/ISO)
Growth hormone receptor binding GO:0005131
Interacting selectively and non-covalently with the growth hormone receptor.
1 P23458 (/ISS)
Protein phosphatase binding GO:0019903
Interacting selectively and non-covalently with any protein phosphatase.
1 P23458 (/IPI)
Protein phosphatase binding GO:0019903
Interacting selectively and non-covalently with any protein phosphatase.
1 P52332 (/ISO)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
1 P23458 (/IPI)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
1 P52332 (/ISO)
CCR5 chemokine receptor binding GO:0031730
Interacting selectively and non-covalently with a CCR5 chemokine receptor.
1 G3V9W2 (/IPI)
CCR5 chemokine receptor binding GO:0031730
Interacting selectively and non-covalently with a CCR5 chemokine receptor.
1 P52332 (/ISO)

There are 32 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
MAPK cascade GO:0000165
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
1 P23458 (/TAS)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
1 P23458 (/TAS)
Enzyme linked receptor protein signaling pathway GO:0007167
Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell, where the receptor possesses catalytic activity or is closely associated with an enzyme such as a protein kinase, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P52332 (/IDA)
Tyrosine phosphorylation of STAT protein GO:0007260
The process of introducing a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
1 P52332 (/IMP)
Peptidyl-tyrosine phosphorylation GO:0018108
The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.
1 P52332 (/IDA)
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P52332 (/IDA)
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P23458 (/TAS)
T cell differentiation in thymus GO:0033077
The process in which a precursor cell type acquires the specialized features of a T cell via a differentiation pathway dependent upon transit through the thymus.
1 O12990 (/IMP)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
1 P52332 (/IDA)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
1 P23458 (/TAS)
Interleukin-12-mediated signaling pathway GO:0035722
A series of molecular signals initiated by the binding of interleukin-12 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P23458 (/TAS)
Interleukin-15-mediated signaling pathway GO:0035723
A series of molecular signals initiated by the binding of interleukin-15 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P23458 (/TAS)
Cellular response to interleukin-3 GO:0036016
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-3 stimulus.
1 P52332 (/IDA)
Interleukin-2-mediated signaling pathway GO:0038110
A series of molecular signals initiated by the binding of interleukin-2 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P23458 (/IDA)
Interleukin-2-mediated signaling pathway GO:0038110
A series of molecular signals initiated by the binding of interleukin-2 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P52332 (/ISO)
Interleukin-2-mediated signaling pathway GO:0038110
A series of molecular signals initiated by the binding of interleukin-2 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P52332 (/ISS)
Interleukin-2-mediated signaling pathway GO:0038110
A series of molecular signals initiated by the binding of interleukin-2 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P23458 (/TAS)
Interleukin-7-mediated signaling pathway GO:0038111
A series of molecular signals initiated by the binding of interleukin-7 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P23458 (/TAS)
Interleukin-9-mediated signaling pathway GO:0038113
A series of molecular signals initiated by the binding of interleukin-9 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P23458 (/TAS)
Interleukin-21-mediated signaling pathway GO:0038114
A series of molecular signals initiated by the binding of interleukin-21 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P23458 (/TAS)
Response to antibiotic GO:0046677
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.
1 P23458 (/IDA)
Response to antibiotic GO:0046677
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.
1 P52332 (/ISO)
Interferon-gamma-mediated signaling pathway GO:0060333
A series of molecular signals initiated by the binding of interferon-gamma to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Interferon gamma is the only member of the type II interferon found so far.
1 P23458 (/TAS)
Regulation of interferon-gamma-mediated signaling pathway GO:0060334
Any process that modulates the rate, frequency or extent of the series of molecular events generated as a consequence of interferon-gamma binding to a cell surface receptor.
1 P23458 (/TAS)
Type I interferon signaling pathway GO:0060337
A series of molecular signals initiated by the binding of a type I interferon to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
1 P23458 (/TAS)
Interleukin-6-mediated signaling pathway GO:0070102
A series of molecular signals initiated by the binding of interleukin-6 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P23458 (/TAS)
Interleukin-27-mediated signaling pathway GO:0070106
A series of molecular signals initiated by the binding of interleukin-27 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P23458 (/TAS)
Interleukin-35-mediated signaling pathway GO:0070757
A series of molecular signals initiated by the binding of interleukin-35 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P23458 (/TAS)
Cellular response to interleukin-7 GO:0098761
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-7 stimulus.
1 P52332 (/IDA)
Positive regulation of sprouting angiogenesis GO:1903672
Any process that activates or increases the frequency, rate or extent of sprouting angiogenesis.
1 P23458 (/IGI)
Positive regulation of sprouting angiogenesis GO:1903672
Any process that activates or increases the frequency, rate or extent of sprouting angiogenesis.
1 P52332 (/ISO)
Positive regulation of receptor signaling pathway via STAT GO:1904894
Any process that activates or increases the frequency, rate or extent of receptor signaling pathway via STAT.
1 P52332 (/IMP)

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P23458 (/TAS) P52332 (/TAS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P23458 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 P52332 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P23458 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P52332 (/ISO)
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
1 P23458 (/TAS)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
1 P23458 (/HDA)