The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Erythroid Transcription Factor GATA-1, subunit A
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 13: Nuclear receptor subfamily 1 group D member 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 37 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
8 F1RAU6 (/IDA) P20393 (/IDA) P20393 (/IDA) P20393 (/IDA) Q503Y6 (/IDA) Q60674 (/IDA) Q60674 (/IDA) Q6TNS3 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
8 P20393 (/IPI) P20393 (/IPI) P20393 (/IPI) Q14995 (/IPI) Q3UV55 (/IPI) Q60674 (/IPI) Q60674 (/IPI) Q63503 (/IPI)
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
6 P13055 (/IDA) P13055 (/IDA) P17671 (/IDA) Q3UV55 (/IDA) Q60674 (/IDA) Q60674 (/IDA)
Heme binding GO:0020037
Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.
6 P13055 (/IDA) P13055 (/IDA) P17671 (/IDA) P20393 (/IDA) P20393 (/IDA) P20393 (/IDA)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
4 P20393 (/IDA) P20393 (/IDA) P20393 (/IDA) Q14995 (/IDA)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
4 P20393 (/ISA) P20393 (/ISA) P20393 (/ISA) Q14995 (/ISA)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
4 P20393 (/ISM) P20393 (/ISM) P20393 (/ISM) Q14995 (/ISM)
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
4 P20393 (/NAS) P20393 (/NAS) P20393 (/NAS) Q14995 (/NAS)
Transcription corepressor binding GO:0001222
Interacting selectively and non-covalently with a transcription corepressor, any protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery.
4 B3SV56 (/ISS) Q08E02 (/ISS) Q3UV55 (/ISS) Q63503 (/ISS)
Nuclear receptor activity GO:0004879
Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II.
4 P20393 (/TAS) P20393 (/TAS) P20393 (/TAS) Q14995 (/TAS)
RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
3 P20393 (/IDA) P20393 (/IDA) P20393 (/IDA)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
3 P20393 (/IMP) P20393 (/IMP) P20393 (/IMP)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
3 Q3UV55 (/ISO) Q60674 (/ISO) Q60674 (/ISO)
Transcription corepressor binding GO:0001222
Interacting selectively and non-covalently with a transcription corepressor, any protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery.
3 P20393 (/IDA) P20393 (/IDA) P20393 (/IDA)
Transcription corepressor binding GO:0001222
Interacting selectively and non-covalently with a transcription corepressor, any protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery.
3 P20393 (/IMP) P20393 (/IMP) P20393 (/IMP)
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
3 F1RAU6 (/IMP) Q503Y6 (/IMP) Q6TNS3 (/IMP)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
3 Q3UV55 (/IDA) Q60674 (/IDA) Q60674 (/IDA)
Steroid hormone receptor activity GO:0003707
Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function.
3 P20393 (/TAS) P20393 (/TAS) P20393 (/TAS)
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
3 P20393 (/TAS) P20393 (/TAS) P20393 (/TAS)
Nuclear receptor activity GO:0004879
Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II.
3 P13055 (/NAS) P13055 (/NAS) P17671 (/NAS)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
3 F1RAU6 (/IDA) Q503Y6 (/IDA) Q6TNS3 (/IDA)
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
3 P20393 (/IDA) P20393 (/IDA) P20393 (/IDA)
E-box binding GO:0070888
Interacting selectively and non-covalently with an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues.
3 B3SV56 (/ISS) Q08E02 (/ISS) Q63503 (/ISS)
RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980
Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter.
2 Q60674 (/IDA) Q60674 (/IDA)
Proximal promoter sequence-specific DNA binding GO:0000987
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter. The proximal promoter is in cis with and relatively close to the core promoter.
2 Q60674 (/IDA) Q60674 (/IDA)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
1 Q63503 (/IDA)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
1 Q3UV55 (/ISO)
RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
1 Q3UV55 (/ISO)
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
1 Q63504 (/ISS)
Proximal promoter sequence-specific DNA binding GO:0000987
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter. The proximal promoter is in cis with and relatively close to the core promoter.
1 Q63504 (/ISS)
Transcription corepressor binding GO:0001222
Interacting selectively and non-covalently with a transcription corepressor, any protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery.
1 Q3UV55 (/ISO)
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
1 Q3UV55 (/ISO)
Heme binding GO:0020037
Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.
1 Q3UV55 (/ISO)
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
1 Q3UV55 (/ISO)
E-box binding GO:0070888
Interacting selectively and non-covalently with an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues.
1 Q3UV55 (/IDA)
Sequence-specific double-stranded DNA binding GO:1990837
Interacting selectively and non-covalently with double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding.
1 Q63503 (/IDA)
Sequence-specific double-stranded DNA binding GO:1990837
Interacting selectively and non-covalently with double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding.
1 Q3UV55 (/ISO)

There are 99 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of lipid metabolic process GO:0019216
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids.
8 B3SV56 (/ISS) P20393 (/ISS) P20393 (/ISS) P20393 (/ISS) Q08E02 (/ISS) Q14995 (/ISS) Q63503 (/ISS) Q63504 (/ISS)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
7 B3DHW0 (/IDA) F1QIC9 (/IDA) F1R8I2 (/IDA) Q3UV55 (/IDA) Q60674 (/IDA) Q60674 (/IDA) Q90Z65 (/IDA)
Regulation of circadian rhythm GO:0042752
Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
7 B3SV56 (/ISS) P20393 (/ISS) P20393 (/ISS) P20393 (/ISS) Q08E02 (/ISS) Q14995 (/ISS) Q63504 (/ISS)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
7 P20393 (/IDA) P20393 (/IDA) P20393 (/IDA) Q14995 (/IDA) Q3UV55 (/IDA) Q60674 (/IDA) Q60674 (/IDA)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
7 B3SV56 (/ISS) P20393 (/ISS) P20393 (/ISS) P20393 (/ISS) Q08E02 (/ISS) Q14995 (/ISS) Q63504 (/ISS)
Glycogen biosynthetic process GO:0005978
The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues.
6 B3SV56 (/ISS) P20393 (/ISS) P20393 (/ISS) P20393 (/ISS) Q08E02 (/ISS) Q63503 (/ISS)
Proteasomal protein catabolic process GO:0010498
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome.
6 B3SV56 (/ISS) P20393 (/ISS) P20393 (/ISS) P20393 (/ISS) Q08E02 (/ISS) Q63503 (/ISS)
Protein destabilization GO:0031648
Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation.
6 B3SV56 (/ISS) P20393 (/ISS) P20393 (/ISS) P20393 (/ISS) Q08E02 (/ISS) Q63503 (/ISS)
Circadian regulation of gene expression GO:0032922
Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
6 B3SV56 (/ISS) P20393 (/ISS) P20393 (/ISS) P20393 (/ISS) Q08E02 (/ISS) Q63503 (/ISS)
Cholesterol homeostasis GO:0042632
Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell.
6 B3SV56 (/ISS) P20393 (/ISS) P20393 (/ISS) P20393 (/ISS) Q08E02 (/ISS) Q63503 (/ISS)
Regulation of circadian sleep/wake cycle GO:0042749
Any process that modulates the frequency, rate or extent of the circadian sleep/wake cycle.
6 B3SV56 (/ISS) P20393 (/ISS) P20393 (/ISS) P20393 (/ISS) Q08E02 (/ISS) Q63503 (/ISS)
Negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124
Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling.
6 B3SV56 (/ISS) P20393 (/ISS) P20393 (/ISS) P20393 (/ISS) Q08E02 (/ISS) Q63503 (/ISS)
Response to leptin GO:0044321
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism].
6 B3SV56 (/ISS) P20393 (/ISS) P20393 (/ISS) P20393 (/ISS) Q08E02 (/ISS) Q63503 (/ISS)
Regulation of fat cell differentiation GO:0045598
Any process that modulates the frequency, rate or extent of adipocyte differentiation.
6 B3SV56 (/ISS) P20393 (/ISS) P20393 (/ISS) P20393 (/ISS) Q08E02 (/ISS) Q63503 (/ISS)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
6 P20393 (/IMP) P20393 (/IMP) P20393 (/IMP) Q3UV55 (/IMP) Q60674 (/IMP) Q60674 (/IMP)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
6 B3SV56 (/ISS) P45447 (/ISS) P45447 (/ISS) Q08E02 (/ISS) Q63503 (/ISS) Q63504 (/ISS)
Negative regulation of inflammatory response GO:0050728
Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response.
6 B3SV56 (/ISS) P20393 (/ISS) P20393 (/ISS) P20393 (/ISS) Q08E02 (/ISS) Q63503 (/ISS)
Circadian temperature homeostasis GO:0060086
Any homeostatic process in which an organism modulates its internal body temperature at different values with a regularity of approximately 24 hours.
6 B3SV56 (/ISS) P20393 (/ISS) P20393 (/ISS) P20393 (/ISS) Q08E02 (/ISS) Q63503 (/ISS)
Regulation of insulin secretion involved in cellular response to glucose stimulus GO:0061178
Any process that modulates the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.
6 B3SV56 (/ISS) P20393 (/ISS) P20393 (/ISS) P20393 (/ISS) Q08E02 (/ISS) Q63503 (/ISS)
Regulation of type B pancreatic cell proliferation GO:0061469
Any process that modulates the frequency, rate or extent of type B pancreatic cell proliferation.
6 B3SV56 (/ISS) P20393 (/ISS) P20393 (/ISS) P20393 (/ISS) Q08E02 (/ISS) Q63503 (/ISS)
Negative regulation of astrocyte activation GO:0061889
Any process that decreases the frequency, rate or extent of astrocyte activation.
6 B3SV56 (/ISS) P20393 (/ISS) P20393 (/ISS) P20393 (/ISS) Q08E02 (/ISS) Q63503 (/ISS)
Positive regulation of bile acid biosynthetic process GO:0070859
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids.
6 B3SV56 (/ISS) P20393 (/ISS) P20393 (/ISS) P20393 (/ISS) Q08E02 (/ISS) Q63503 (/ISS)
Cellular response to interleukin-1 GO:0071347
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.
6 B3SV56 (/ISS) P20393 (/ISS) P20393 (/ISS) P20393 (/ISS) Q08E02 (/ISS) Q63503 (/ISS)
Cellular response to tumor necrosis factor GO:0071356
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
6 B3SV56 (/ISS) P20393 (/ISS) P20393 (/ISS) P20393 (/ISS) Q08E02 (/ISS) Q63503 (/ISS)
Negative regulation of cold-induced thermogenesis GO:0120163
Any process that stops, prevents, or reduces the rate of cold-induced thermogenesis.
6 G3V770 (/ISS) G3V9L8 (/ISS) P20393 (/ISS) P20393 (/ISS) P20393 (/ISS) Q63503 (/ISS)
Negative regulation of neuroinflammatory response GO:0150079
Any process that stops, prevents or reduces the frequency, rate or extent of neuroinflammatory response.
6 B3SV56 (/ISS) P20393 (/ISS) P20393 (/ISS) P20393 (/ISS) Q08E02 (/ISS) Q63503 (/ISS)
Negative regulation of microglial cell activation GO:1903979
Any process that stops, prevents or reduces the frequency, rate or extent of microglial cell activation.
6 B3SV56 (/ISS) P20393 (/ISS) P20393 (/ISS) P20393 (/ISS) Q08E02 (/ISS) Q63503 (/ISS)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
5 P20393 (/IDA) P20393 (/IDA) P20393 (/IDA) Q60674 (/IDA) Q60674 (/IDA)
Transcription initiation from RNA polymerase II promoter GO:0006367
Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription.
4 P20393 (/TAS) P20393 (/TAS) P20393 (/TAS) Q14995 (/TAS)
Circadian regulation of gene expression GO:0032922
Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
4 B3DHW0 (/IDA) F1QIC9 (/IDA) F1R8I2 (/IDA) Q90Z65 (/IDA)
Circadian regulation of gene expression GO:0032922
Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
4 F1RAU6 (/IMP) Q3UV55 (/IMP) Q503Y6 (/IMP) Q6TNS3 (/IMP)
Regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter GO:0035947
Any process that modulates the frequency, rate or extent of gluconeogenesis, by regulation of transcription from an RNA polymerase II promoter.
4 B3SV56 (/ISS) Q08E02 (/ISS) Q3UV55 (/ISS) Q63503 (/ISS)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
3 P20393 (/IMP) P20393 (/IMP) P20393 (/IMP)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
3 P13055 (/ISS) P13055 (/ISS) P17671 (/ISS)
Autophagy GO:0006914
The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation.
3 F1RAU6 (/IMP) Q503Y6 (/IMP) Q6TNS3 (/IMP)
Regulation of ecdysteroid metabolic process GO:0007553
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development, including the metamorphosis of immature forms and the development of the reproductive system and the maturation of oocytes in adult females.
3 P13055 (/IMP) P13055 (/IMP) P17671 (/IMP)
Molting cycle, chitin-based cuticle GO:0007591
The periodic shedding of part or all of a chitin-based cuticle, which is then replaced by a new cuticle. An example of this is found in Drosophila melanogaster.
3 P13055 (/IMP) P13055 (/IMP) P17671 (/IMP)
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
3 P20393 (/TAS) P20393 (/TAS) P20393 (/TAS)
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
3 P13055 (/IDA) P13055 (/IDA) P17671 (/IDA)
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
3 F1RAU6 (/IGI) Q503Y6 (/IGI) Q6TNS3 (/IGI)
Negative regulation of receptor biosynthetic process GO:0010871
Any process that decreases the frequency or rate of receptor biosynthesis. Receptor biosynthesis is the collection of chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
3 P20393 (/IMP) P20393 (/IMP) P20393 (/IMP)
Ecdysis, chitin-based cuticle GO:0018990
The shedding of the old chitin-based cuticlar fragments during the molting cycle. An example of this is found in Drosophila melanogaster.
3 P13055 (/IMP) P13055 (/IMP) P17671 (/IMP)
Regulation of lipid metabolic process GO:0019216
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids.
3 Q3UV55 (/IMP) Q60674 (/IMP) Q60674 (/IMP)
Antimicrobial humoral response GO:0019730
An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus.
3 P13055 (/IMP) P13055 (/IMP) P17671 (/IMP)
Negative regulation of toll-like receptor 4 signaling pathway GO:0034144
Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 4 signaling pathway.
3 P20393 (/IMP) P20393 (/IMP) P20393 (/IMP)
Response to ecdysone GO:0035075
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ecdysone stimulus.
3 P13055 (/IMP) P13055 (/IMP) P17671 (/IMP)
Regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter GO:0035947
Any process that modulates the frequency, rate or extent of gluconeogenesis, by regulation of transcription from an RNA polymerase II promoter.
3 P20393 (/IMP) P20393 (/IMP) P20393 (/IMP)
Regulation of circadian rhythm GO:0042752
Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
3 Q60674 (/IDA) Q60674 (/IDA) Q63503 (/IDA)
Regulation of circadian rhythm GO:0042752
Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
3 Q3UV55 (/IMP) Q60674 (/IMP) Q60674 (/IMP)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
3 Q3UV55 (/ISO) Q60674 (/ISO) Q60674 (/ISO)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
3 Q3UV55 (/IMP) Q60674 (/IMP) Q60674 (/IMP)
Oogenesis GO:0048477
The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster.
3 P13055 (/NAS) P13055 (/NAS) P17671 (/NAS)
Negative regulation of inflammatory response GO:0050728
Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response.
3 Q3UV55 (/IMP) Q60674 (/IMP) Q60674 (/IMP)
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
3 P20393 (/IMP) P20393 (/IMP) P20393 (/IMP)
Regulation of locomotor rhythm GO:1904059
Any process that modulates the frequency, rate or extent of locomotor rhythm.
3 F1RAU6 (/IMP) Q503Y6 (/IMP) Q6TNS3 (/IMP)
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
2 Q3UV55 (/IEP) Q63503 (/IEP)
Circadian behavior GO:0048512
The specific behavior of an organism that recurs with a regularity of approximately 24 hours.
2 Q60674 (/IMP) Q60674 (/IMP)
Circadian behavior GO:0048512
The specific behavior of an organism that recurs with a regularity of approximately 24 hours.
2 Q14995 (/ISS) Q63504 (/ISS)
Regulation of inflammatory response GO:0050727
Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents.
2 Q60674 (/IMP) Q60674 (/IMP)
Regulation of inflammatory response GO:0050727
Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents.
2 Q14995 (/ISS) Q63504 (/ISS)
Lipid homeostasis GO:0055088
Any process involved in the maintenance of an internal steady state of lipid within an organism or cell.
2 Q60674 (/IMP) Q60674 (/IMP)
Lipid homeostasis GO:0055088
Any process involved in the maintenance of an internal steady state of lipid within an organism or cell.
2 Q14995 (/ISS) Q63504 (/ISS)
Energy homeostasis GO:0097009
Any process involved in the balance between food intake (energy input) and energy expenditure.
2 Q60674 (/IMP) Q60674 (/IMP)
Energy homeostasis GO:0097009
Any process involved in the balance between food intake (energy input) and energy expenditure.
2 Q14995 (/ISS) Q63504 (/ISS)
Regulation of skeletal muscle cell differentiation GO:2001014
Any process that modulates the frequency, rate or extent of skeletal muscle cell differentiation.
2 Q60674 (/IMP) Q60674 (/IMP)
Regulation of skeletal muscle cell differentiation GO:2001014
Any process that modulates the frequency, rate or extent of skeletal muscle cell differentiation.
2 Q14995 (/ISS) Q63504 (/ISS)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 Q3UV55 (/ISO)
Glycogen biosynthetic process GO:0005978
The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues.
1 Q3UV55 (/IMP)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
1 Q14995 (/TAS)
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
1 Q3UV55 (/IDA)
Photoperiodism GO:0009648
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a period of light or dark of a given length, measured relative to a particular duration known as the 'critical day length'. The critical day length varies between species.
1 Q63503 (/IEP)
Proteasomal protein catabolic process GO:0010498
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome.
1 Q3UV55 (/IDA)
Negative regulation of receptor biosynthetic process GO:0010871
Any process that decreases the frequency or rate of receptor biosynthesis. Receptor biosynthesis is the collection of chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
1 Q3UV55 (/ISO)
Protein destabilization GO:0031648
Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation.
1 Q3UV55 (/IMP)
Negative regulation of toll-like receptor 4 signaling pathway GO:0034144
Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 4 signaling pathway.
1 Q3UV55 (/ISO)
Regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter GO:0035947
Any process that modulates the frequency, rate or extent of gluconeogenesis, by regulation of transcription from an RNA polymerase II promoter.
1 Q3UV55 (/ISO)
Cholesterol homeostasis GO:0042632
Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell.
1 Q3UV55 (/IMP)
Regulation of circadian sleep/wake cycle GO:0042749
Any process that modulates the frequency, rate or extent of the circadian sleep/wake cycle.
1 Q3UV55 (/IMP)
Regulation of circadian rhythm GO:0042752
Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
1 Q3UV55 (/ISO)
Positive regulation of circadian rhythm GO:0042753
Any process that activates or increases the frequency, rate or extent of a circadian rhythm behavior.
1 Q63503 (/IDA)
Positive regulation of circadian rhythm GO:0042753
Any process that activates or increases the frequency, rate or extent of a circadian rhythm behavior.
1 Q3UV55 (/ISO)
Negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124
Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling.
1 Q3UV55 (/IMP)
Response to leptin GO:0044321
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism].
1 Q3UV55 (/IDA)
Regulation of fat cell differentiation GO:0045598
Any process that modulates the frequency, rate or extent of adipocyte differentiation.
1 Q3UV55 (/IMP)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 Q63503 (/IDA)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 Q3UV55 (/ISO)
Circadian temperature homeostasis GO:0060086
Any homeostatic process in which an organism modulates its internal body temperature at different values with a regularity of approximately 24 hours.
1 Q3UV55 (/IMP)
Regulation of insulin secretion involved in cellular response to glucose stimulus GO:0061178
Any process that modulates the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.
1 Q3UV55 (/IMP)
Regulation of type B pancreatic cell proliferation GO:0061469
Any process that modulates the frequency, rate or extent of type B pancreatic cell proliferation.
1 Q3UV55 (/IMP)
Negative regulation of astrocyte activation GO:0061889
Any process that decreases the frequency, rate or extent of astrocyte activation.
1 Q3UV55 (/IMP)
Positive regulation of bile acid biosynthetic process GO:0070859
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids.
1 Q3UV55 (/IMP)
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
1 Q3UV55 (/ISO)
Cellular response to interleukin-1 GO:0071347
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.
1 Q3UV55 (/IDA)
Cellular response to tumor necrosis factor GO:0071356
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
1 Q3UV55 (/IDA)
Negative regulation of cold-induced thermogenesis GO:0120163
Any process that stops, prevents, or reduces the rate of cold-induced thermogenesis.
1 Q3UV55 (/IMP)
Negative regulation of neuroinflammatory response GO:0150079
Any process that stops, prevents or reduces the frequency, rate or extent of neuroinflammatory response.
1 Q3UV55 (/IMP)
Negative regulation of microglial cell activation GO:1903979
Any process that stops, prevents or reduces the frequency, rate or extent of microglial cell activation.
1 Q3UV55 (/IMP)
Regulation of hepatic stellate cell activation GO:2000489
Any process that modulates the frequency, rate or extent of hepatic stellate cell activation.
1 Q63503 (/IDA)
Regulation of hepatic stellate cell activation GO:2000489
Any process that modulates the frequency, rate or extent of hepatic stellate cell activation.
1 Q3UV55 (/ISO)

There are 22 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
9 B3SV56 (/ISS) P20393 (/ISS) P20393 (/ISS) P20393 (/ISS) Q08E02 (/ISS) Q60674 (/ISS) Q60674 (/ISS) Q63503 (/ISS) Q63504 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
8 B3SV56 (/ISS) P20393 (/ISS) P20393 (/ISS) P20393 (/ISS) Q08E02 (/ISS) Q14995 (/ISS) Q63503 (/ISS) Q63504 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
7 P13055 (/IDA) P13055 (/IDA) P17671 (/IDA) Q14995 (/IDA) Q3UV55 (/IDA) Q60674 (/IDA) Q60674 (/IDA)
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
6 F1D8S3 (/IDA) F1D8S3 (/IDA) F1D8S3 (/IDA) P20393 (/IDA) P20393 (/IDA) P20393 (/IDA)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
6 B3SV56 (/ISS) P20393 (/ISS) P20393 (/ISS) P20393 (/ISS) Q08E02 (/ISS) Q63503 (/ISS)
Dendritic spine GO:0043197
A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including \thin\, \stubby\, \mushroom\, and \branched\, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
6 B3SV56 (/ISS) P20393 (/ISS) P20393 (/ISS) P20393 (/ISS) Q08E02 (/ISS) Q63503 (/ISS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
5 P20393 (/TAS) P20393 (/TAS) P20393 (/TAS) Q14995 (/TAS) Q3UV55 (/TAS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
4 P20393 (/TAS) P20393 (/TAS) P20393 (/TAS) Q14995 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 Q3UV55 (/IDA) Q60674 (/IDA) Q60674 (/IDA) Q63503 (/IDA)
Chromatin GO:0000785
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
3 F1RAU6 (/IDA) Q503Y6 (/IDA) Q6TNS3 (/IDA)
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
3 P20393 (/IDA) P20393 (/IDA) P20393 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q60674 (/ISO) Q60674 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 F1D8P2 (/IDA) Q14995 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 Q60674 (/ISO) Q60674 (/ISO)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
2 Q3UV55 (/IDA) Q63503 (/IDA)
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
1 Q3UV55 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q3UV55 (/ISO)
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
1 Q3UV55 (/ISO)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
1 Q3UV55 (/ISO)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 Q63503 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 Q3UV55 (/ISO)
Dendritic spine GO:0043197
A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including \thin\, \stubby\, \mushroom\, and \branched\, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
1 Q3UV55 (/IDA)