The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Aconitase, domain 3
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 14: Aconitate hydratase 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 8 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Aconitate hydratase activity GO:0003994
Catalysis of the reaction: citrate = isocitrate. The reaction occurs in two steps: (1) citrate = cis-aconitate + H2O, (2) cis-aconitate + H2O = isocitrate. This reaction is the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate.
14 Q8IDR8 (/IDA) Q8IDR8 (/IDA) Q8IDR8 (/IDA) Q8IDR8 (/IDA) Q8IDR8 (/IDA) Q8IDR8 (/IDA) Q8IDR8 (/IDA) Q8IDR8 (/IDA) Q8IDR8 (/IDA) Q8IDR8 (/IDA)
(4 more)
Iron ion binding GO:0005506
Interacting selectively and non-covalently with iron (Fe) ions.
13 Q8IDR8 (/ISS) Q8IDR8 (/ISS) Q8IDR8 (/ISS) Q8IDR8 (/ISS) Q8IDR8 (/ISS) Q8IDR8 (/ISS) Q8IDR8 (/ISS) Q8IDR8 (/ISS) Q8IDR8 (/ISS) Q8IDR8 (/ISS)
(3 more)
Aconitate hydratase activity GO:0003994
Catalysis of the reaction: citrate = isocitrate. The reaction occurs in two steps: (1) citrate = cis-aconitate + H2O, (2) cis-aconitate + H2O = isocitrate. This reaction is the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate.
7 Q8EJW3 (/ISS) Q9KSC0 (/ISS) Q9KSC0 (/ISS) Q9KSC0 (/ISS) Q9KSC0 (/ISS) Q9KSC0 (/ISS) Q9KSC0 (/ISS)
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
1 Q937N8 (/ISS)
MRNA 3'-UTR binding GO:0003730
Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule.
1 Q937N8 (/ISS)
Hydro-lyase activity GO:0016836
Catalysis of the cleavage of a carbon-oxygen bond by elimination of water.
1 Q8EJW3 (/IDA)
2-methylisocitrate dehydratase activity GO:0047456
Catalysis of the reaction: (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = cis-2-methylaconitate + H(2)O.
1 Q937N8 (/ISS)
4 iron, 4 sulfur cluster binding GO:0051539
Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
1 Q937N8 (/ISS)

There are 5 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Tricarboxylic acid cycle GO:0006099
A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
20 Q8EJW3 (/ISS) Q8IDR8 (/ISS) Q8IDR8 (/ISS) Q8IDR8 (/ISS) Q8IDR8 (/ISS) Q8IDR8 (/ISS) Q8IDR8 (/ISS) Q8IDR8 (/ISS) Q8IDR8 (/ISS) Q8IDR8 (/ISS)
(10 more)
Regulation of translational initiation by iron GO:0006447
Any process that modulates the frequency, rate or extent of the translation of certain mRNAs involved in iron metabolism; regulated by the concentration of iron.
13 Q8IDR8 (/ISS) Q8IDR8 (/ISS) Q8IDR8 (/ISS) Q8IDR8 (/ISS) Q8IDR8 (/ISS) Q8IDR8 (/ISS) Q8IDR8 (/ISS) Q8IDR8 (/ISS) Q8IDR8 (/ISS) Q8IDR8 (/ISS)
(3 more)
Tricarboxylic acid cycle GO:0006099
A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle.
1 Q937N8 (/TAS)
Propionate catabolic process, 2-methylcitrate cycle GO:0019629
The chemical reactions and pathways resulting in the breakdown of propionate that occurs in the 2-methylcitrate cycle.
1 Q8EJW3 (/IDA)
Propionate metabolic process, methylcitrate cycle GO:0019679
The chemical reactions and pathways involving propionate that occur in the methylcitrate cycle.
1 Q937N8 (/TAS)

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
13 Q8IDR8 (/IDA) Q8IDR8 (/IDA) Q8IDR8 (/IDA) Q8IDR8 (/IDA) Q8IDR8 (/IDA) Q8IDR8 (/IDA) Q8IDR8 (/IDA) Q8IDR8 (/IDA) Q8IDR8 (/IDA) Q8IDR8 (/IDA)
(3 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
13 Q8IDR8 (/IDA) Q8IDR8 (/IDA) Q8IDR8 (/IDA) Q8IDR8 (/IDA) Q8IDR8 (/IDA) Q8IDR8 (/IDA) Q8IDR8 (/IDA) Q8IDR8 (/IDA) Q8IDR8 (/IDA) Q8IDR8 (/IDA)
(3 more)
Food vacuole GO:0020020
Vacuole within a parasite used for digestion of the host cell cytoplasm. An example of this component is found in the Apicomplexa.
13 Q8IDR8 (/IDA) Q8IDR8 (/IDA) Q8IDR8 (/IDA) Q8IDR8 (/IDA) Q8IDR8 (/IDA) Q8IDR8 (/IDA) Q8IDR8 (/IDA) Q8IDR8 (/IDA) Q8IDR8 (/IDA) Q8IDR8 (/IDA)
(3 more)