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CATH Superfamily 3.30.46.10

Glycine N-methyltransferase, chain A, domain 1

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Glycine N-methyltransferase, chain A, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily EC Annotations

Note: the EC figure is not being displayed for this superfamily as there are more than 100 different EC terms.

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Glycine N-methyltransferase. [EC: 2.1.1.20]
S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine.
  • Thought to play an important role in the regulation of methyl group metabolism in the liver and pancreas by regulating the ratio between S-adenosyl-L-methionine and S-adenosyl-L-homocysteine.
  • Inhibited by 5-methyltetrahydrofolate pentaglutamate.
  • Sarcosine, which has no physiological role, is converted back into glycine by the action of EC 1.5.8.3.
 9 A0A2R8ZA16 G3RCK3 H2QT12 P13255 Q14749 Q29513 Q29555 Q9QXF8 V9HW60
Glycine/sarcosine N-methyltransferase. [EC: 2.1.1.156]
2 S-adenosyl-L-methionine + glycine = 2 S-adenosyl-L-homocysteine + N,N-dimethylglycine.
  • Cells of the oxygen-evolving halotolerant cyanobacterium Aphanocthece halophytica synthesize betaine from glycine by a three-step methylation process.
  • This is the first enzyme and it leads to the formation of either sarcosine or N,N-dimethylglycine, which is further methylated to yield betaine (N,N,N-trimethylglycine) by the action of EC 2.1.1.157.
  • Differs from EC 2.1.1.20, as it can further methylate the product of the first reaction.
  • Acetate, dimethylglycine and S-adenosyl-L-homocysteine can inhibit the reaction.
 6 A0A0X8XA52 K9YF78 Q7U4Z8 Q83WC4 Q9KJ20 Q9KJ22
Sarcosine/dimethylglycine N-methyltransferase. [EC: 2.1.1.157]
2 S-adenosyl-L-methionine + sarcosine = 2 S-adenosyl-L-homocysteine + betaine.
  • Cells of the oxygen-evolving halotolerant cyanobacterium Aphanocthece halophytica synthesize betaine from glycine by a three-step methylation process.
  • The first enzyme, EC 2.1.1.156, leads to the formation of either sarcosine or N,N-dimethylglycine, which is further methylated to yield betaine (N,N,N-trimethylglycine) by the action of this enzyme.
  • Both of these enzymes can catalyze the formation of N,N-dimethylglycine from sarcosine.
  • The reactions are strongly inhibited by S-adenosyl-L-homocysteine.
 1 Q9KJ20