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CATH Superfamily 3.30.450.30

Dynein light chain 2a, cytoplasmic

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Dynein light chain 2a, cytoplasmic
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4: ragulator complex protein LAMTOR2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 1 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
 51 Q9JHS3 (/IPI) Q9JHS3 (/IPI) Q9Y2Q5 (/IPI) Q9Y2Q5 (/IPI) Q9Y2Q5 (/IPI) Q9Y2Q5 (/IPI) Q9Y2Q5 (/IPI) Q9Y2Q5 (/IPI) Q9Y2Q5 (/IPI) Q9Y2Q5 (/IPI)
(41 more)

There are 18 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of cell growth GO:0001558
Any process that modulates the frequency, rate, extent or direction of cell growth.
 71 B5FYY5 (/ISS) B5FYY5 (/ISS) B5FYY5 (/ISS) B5FYY5 (/ISS) B5FYY5 (/ISS) B5FYY5 (/ISS) B5FYY5 (/ISS) B5FYY5 (/ISS) B5X7X4 (/ISS) B5X7X4 (/ISS)
(61 more)
Cellular protein localization GO:0034613
Any process in which a protein is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell.
 71 B5FYY5 (/ISS) B5FYY5 (/ISS) B5FYY5 (/ISS) B5FYY5 (/ISS) B5FYY5 (/ISS) B5FYY5 (/ISS) B5FYY5 (/ISS) B5FYY5 (/ISS) B5X7X4 (/ISS) B5X7X4 (/ISS)
(61 more)
Cellular response to amino acid stimulus GO:0071230
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups.
 71 B5FYY5 (/ISS) B5FYY5 (/ISS) B5FYY5 (/ISS) B5FYY5 (/ISS) B5FYY5 (/ISS) B5FYY5 (/ISS) B5FYY5 (/ISS) B5FYY5 (/ISS) B5X7X4 (/ISS) B5X7X4 (/ISS)
(61 more)
Positive regulation of TOR signaling GO:0032008
Any process that activates or increases the frequency, rate or extent of TOR signaling.
 69 B5FYY5 (/ISS) B5FYY5 (/ISS) B5FYY5 (/ISS) B5FYY5 (/ISS) B5FYY5 (/ISS) B5FYY5 (/ISS) B5FYY5 (/ISS) B5FYY5 (/ISS) B5X7X4 (/ISS) B5X7X4 (/ISS)
(59 more)
Positive regulation of TOR signaling GO:0032008
Any process that activates or increases the frequency, rate or extent of TOR signaling.
 51 Q9V8I2 (/IMP) Q9V8I2 (/IMP) Q9Y2Q5 (/IMP) Q9Y2Q5 (/IMP) Q9Y2Q5 (/IMP) Q9Y2Q5 (/IMP) Q9Y2Q5 (/IMP) Q9Y2Q5 (/IMP) Q9Y2Q5 (/IMP) Q9Y2Q5 (/IMP)
(41 more)
Cellular response to amino acid stimulus GO:0071230
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups.
 51 Q9V8I2 (/IMP) Q9V8I2 (/IMP) Q9Y2Q5 (/IMP) Q9Y2Q5 (/IMP) Q9Y2Q5 (/IMP) Q9Y2Q5 (/IMP) Q9Y2Q5 (/IMP) Q9Y2Q5 (/IMP) Q9Y2Q5 (/IMP) Q9Y2Q5 (/IMP)
(41 more)
MAPK cascade GO:0000165
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
 49 Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS)
(39 more)
Regulation of cell growth GO:0001558
Any process that modulates the frequency, rate, extent or direction of cell growth.
 49 Q9Y2Q5 (/IMP) Q9Y2Q5 (/IMP) Q9Y2Q5 (/IMP) Q9Y2Q5 (/IMP) Q9Y2Q5 (/IMP) Q9Y2Q5 (/IMP) Q9Y2Q5 (/IMP) Q9Y2Q5 (/IMP) Q9Y2Q5 (/IMP) Q9Y2Q5 (/IMP)
(39 more)
Cell cycle arrest GO:0007050
A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M).
 49 Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS)
(39 more)
Regulation of macroautophagy GO:0016241
Any process that modulates the frequency, rate or extent of macroautophagy.
 49 Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS)
(39 more)
Cellular protein localization GO:0034613
Any process in which a protein is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell.
 49 Q9Y2Q5 (/IMP) Q9Y2Q5 (/IMP) Q9Y2Q5 (/IMP) Q9Y2Q5 (/IMP) Q9Y2Q5 (/IMP) Q9Y2Q5 (/IMP) Q9Y2Q5 (/IMP) Q9Y2Q5 (/IMP) Q9Y2Q5 (/IMP) Q9Y2Q5 (/IMP)
(39 more)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
 49 Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS)
(39 more)
Activation of MAPKK activity GO:0000186
The initiation of the activity of the inactive enzyme MAP kinase kinase (MAPKK).
 2 Q9JHS3 (/IDA) Q9JHS3 (/IDA)
Regulation of cell growth GO:0001558
Any process that modulates the frequency, rate, extent or direction of cell growth.
 2 Q9JHS3 (/ISO) Q9JHS3 (/ISO)
Positive regulation of TOR signaling GO:0032008
Any process that activates or increases the frequency, rate or extent of TOR signaling.
 2 Q9JHS3 (/ISO) Q9JHS3 (/ISO)
Cellular protein localization GO:0034613
Any process in which a protein is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell.
 2 Q9JHS3 (/ISO) Q9JHS3 (/ISO)
Cellular response to amino acid stimulus GO:0071230
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups.
 2 Q9JHS3 (/ISO) Q9JHS3 (/ISO)
Activation of MAPKK activity GO:0000186
The initiation of the activity of the inactive enzyme MAP kinase kinase (MAPKK).
 1 Q54F59 (/ISS)

There are 11 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Late endosome GO:0005770
A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
 116 B5FYY5 (/ISS) B5FYY5 (/ISS) B5FYY5 (/ISS) B5FYY5 (/ISS) B5FYY5 (/ISS) B5FYY5 (/ISS) B5FYY5 (/ISS) B5FYY5 (/ISS) B5X7X4 (/ISS) B5X7X4 (/ISS)
(106 more)
Ragulator complex GO:0071986
A eukaryotically conserved protein complex; in humans, it is comprised of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4, and LAMTOR5. The complex is anchored to lipid rafts in late endosome membranes via LAMTOR1, constitutes a guanine nucleotide exchange factor (GEF) for the Rag GTPases.
 70 B5FYY5 (/ISS) B5FYY5 (/ISS) B5FYY5 (/ISS) B5FYY5 (/ISS) B5FYY5 (/ISS) B5FYY5 (/ISS) B5FYY5 (/ISS) B5FYY5 (/ISS) B5X7X4 (/ISS) B5X7X4 (/ISS)
(60 more)
Lysosomal membrane GO:0005765
The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
 49 Q9Y2Q5 (/HDA) Q9Y2Q5 (/HDA) Q9Y2Q5 (/HDA) Q9Y2Q5 (/HDA) Q9Y2Q5 (/HDA) Q9Y2Q5 (/HDA) Q9Y2Q5 (/HDA) Q9Y2Q5 (/HDA) Q9Y2Q5 (/HDA) Q9Y2Q5 (/HDA)
(39 more)
Lysosomal membrane GO:0005765
The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
 49 Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS)
(39 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
 49 Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS)
(39 more)
Endosome membrane GO:0010008
The lipid bilayer surrounding an endosome.
 49 Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS)
(39 more)
Specific granule membrane GO:0035579
The lipid bilayer surrounding a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.
 49 Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS)
(39 more)
Tertiary granule membrane GO:0070821
The lipid bilayer surrounding a tertiary granule.
 49 Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS) Q9Y2Q5 (/TAS)
(39 more)
Ragulator complex GO:0071986
A eukaryotically conserved protein complex; in humans, it is comprised of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4, and LAMTOR5. The complex is anchored to lipid rafts in late endosome membranes via LAMTOR1, constitutes a guanine nucleotide exchange factor (GEF) for the Rag GTPases.
 49 Q9Y2Q5 (/IDA) Q9Y2Q5 (/IDA) Q9Y2Q5 (/IDA) Q9Y2Q5 (/IDA) Q9Y2Q5 (/IDA) Q9Y2Q5 (/IDA) Q9Y2Q5 (/IDA) Q9Y2Q5 (/IDA) Q9Y2Q5 (/IDA) Q9Y2Q5 (/IDA)
(39 more)
Late endosome GO:0005770
A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center.
 2 Q9JHS3 (/IDA) Q9JHS3 (/IDA)
Ragulator complex GO:0071986
A eukaryotically conserved protein complex; in humans, it is comprised of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4, and LAMTOR5. The complex is anchored to lipid rafts in late endosome membranes via LAMTOR1, constitutes a guanine nucleotide exchange factor (GEF) for the Rag GTPases.
 2 Q9JHS3 (/ISO) Q9JHS3 (/ISO)