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CATH Superfamily 3.30.428.10

HIT-like

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
HIT-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily EC Annotations

Note: the EC figure is not being displayed for this superfamily as there are more than 100 different EC terms.

There are 9 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
UDP-glucose--hexose-1-phosphate uridylyltransferase. [EC: 2.7.7.12]
UDP-alpha-D-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose.
    		 208 A0A069XWL8 A0A069XWL8 A0A070SPW9 A0A070SPW9 A0A0B0E8F0 A0A0B0E8F0 A0A0D6GZL6 A0A0D6GZL6 A0A0E0TV27 A0A0E0TV27
    (198 more...)
    Adenosine-5'-diphospho-5'-(DNA) diphosphatase. [EC: 3.1.11.7]
    (1) Adenosine-5'-diphospho-5'-(DNA) + H(2)O = AMP + phospho-5'-(DNA). (2) Adenosine-5'-diphospho-5'-(ribonucleotide)-(DNA) + H(2)O = AMP + 5'-phospho-(ribonucleotide)-(DNA).
    • Aprataxin is a DNA-binding protein involved in different types of DNA break repair.
    • The enzyme acts (among other activities) on abortive DNA ligation intermediates that contain an adenylate covalently linked to the 5'-phosphate DNA terminus.
    • It also acts when the adenylate is covalently linked to the 5'-phosphate of a ribonucleotide linked to a DNA strand, which is the result of abortive ligase activty on products of EC 3.1.26.4, an enzyme that cleaves RNA-DNA hybrids on the 5' side of the ribonucleotide found in the 5'-RNA-DNA-3' junction.
    • Aprataxin binds the adenylate group to a histidine residue within the active site, followed by its hydrolysis from the nucleic acid and eventual release, leaving a 5'-phosphate terminus that can be efficiently rejoined.
    • The enzyme also possesses the activities of EC 3.1.11.8 and EC 3.1.12.2.
    		 20 A9UL60 C7GWD1 C8ZH09 H9YUS5 N1NYS3 O74859 P61797 P61798 P61799 P61800
    (10 more...)
    DNA-3'-diphospho-5'-guanosine diphosphatase. [EC: 3.1.12.2]
    (DNA)-3'-diphospho-5'-guanosine + H(2)O = (DNA)-3'-phosphate + GMP.
    • Aprataxin is a DNA-binding protein that catalyzes (among other activities) the 3' decapping of DNA-ppG (formed by EC 6.5.1.8).
    • The enzyme binds the guanylate group to a histidine residue at its active site, forming a covalent enzyme-nucleotide phosphate intermediate, followed by the hydrolysis of the guanylate from the nucleic acid and its eventual release.
    • The enzyme also possesses the activity of EC 3.1.11.7 and EC 3.1.11.8.
    		 20 A9UL60 C7GWD1 C8ZH09 H9YUS5 N1NYS3 O74859 P61797 P61798 P61799 P61800
    (10 more...)
    5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase. [EC: 3.6.1.59]
    A 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] + H(2)O = N(7)- methylguanosine 5'-phosphate + a 5'-diphospho-[mRNA].
    • The enzyme removes (decaps) the N(7)-methylguanosine 5-phosphate cap from an mRNA degraded to a maximal length of 10 nucleotides.
    • Decapping is an important process in the control of eukaryotic mRNA degradation.
    • The enzyme functions to clear the cell of cap structure following decay of the RNA body.
    • The nematode enzyme can also decap triply methylated substrates, 5'-(N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-[mRNA].
    • Formerly EC 3.6.1.30.
    		 18 A0A0L8VL28 A0A384MTI8 A0A480PF49 A7A1F1 B3RHF3 C7GQX1 C8ZDN4 D3K0N9 G2WJ95 G5EFS4
    (8 more...)
    Bis(5'-adenosyl)-triphosphatase. [EC: 3.6.1.29]
    P(1)-P(3)-bis(5'-adenosyl) triphosphate + H(2)O = ADP + AMP.
      		 17 A0A024R366 A0A178UKE7 A6ZYQ3 B3LFZ1 B5VGI4 C7GQV5 C8Z5L6 F4KEV7 N1PAH4 O76463
      (7 more...)
      ATP adenylyltransferase. [EC: 2.7.7.53]
      ADP + ATP = phosphate + P(1),P(4)-bis(5'-adenosyl) tetraphosphate.
      • GTP and adenosine tetraphosphate can also act as adenylyl acceptors.
      		 13 A0A045IIB8 A0A0H3LJ75 A0A0H3M7J4 A0A0K2HYR5 A0A109SQE8 A0A109SYX6 A0A1R3Y1Q2 A0A328GD76 A5U5W4 G0TQL1
      (3 more...)
      Adenylylsulfatase. [EC: 3.6.2.1]
      Adenylyl sulfate + H(2)O = AMP + sulfate.
        		 8 A0A178UAY8 A0A178UKE7 A0A178UVT4 A0A178VI77 F4K1R2 F4KEV7 Q84VV6 Q8GUN2
        Sulfate adenylyltransferase (ADP). [EC: 2.7.7.5]
        ADP + sulfate = phosphate + adenylyl sulfate.
          		 2 A0A178UVT4 Q84VV6
          Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical). [EC: 3.6.1.17]
          P(1),P(4)-bis(5'-guanosyl) tetraphosphate + H(2)O = GTP + GMP.
          • Also acts on bis(5'-xanthosyl)-tetraphosphate and, more slowly, on bis(5'-adenosyl)-tetraphosphate and bis(5'-uridyl)-tetraphosphate (cf. EC 3.6.1.41).
          		 1 P49776