The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 20: Chaperone protein HscA homolog

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 18 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
91 P0A6Z1 (/IPI) P0A6Z1 (/IPI) P0A6Z1 (/IPI) P0A6Z1 (/IPI) P0A6Z1 (/IPI) P0A6Z1 (/IPI) P0A6Z1 (/IPI) P0A6Z1 (/IPI) P0A6Z1 (/IPI) P0A6Z1 (/IPI)
(81 more)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
87 P0A6Z1 (/IDA) P0A6Z1 (/IDA) P0A6Z1 (/IDA) P0A6Z1 (/IDA) P0A6Z1 (/IDA) P0A6Z1 (/IDA) P0A6Z1 (/IDA) P0A6Z1 (/IDA) P0A6Z1 (/IDA) P0A6Z1 (/IDA)
(77 more)
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
87 P0A6Z1 (/IDA) P0A6Z1 (/IDA) P0A6Z1 (/IDA) P0A6Z1 (/IDA) P0A6Z1 (/IDA) P0A6Z1 (/IDA) P0A6Z1 (/IDA) P0A6Z1 (/IDA) P0A6Z1 (/IDA) P0A6Z1 (/IDA)
(77 more)
ADP binding GO:0043531
Interacting selectively and non-covalently with ADP, adenosine 5'-diphosphate.
87 P0A6Z1 (/IDA) P0A6Z1 (/IDA) P0A6Z1 (/IDA) P0A6Z1 (/IDA) P0A6Z1 (/IDA) P0A6Z1 (/IDA) P0A6Z1 (/IDA) P0A6Z1 (/IDA) P0A6Z1 (/IDA) P0A6Z1 (/IDA)
(77 more)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
3 F1QFC0 (/NAS) Q5XJ12 (/NAS) Q7ZYY3 (/NAS)
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
3 F1QFC0 (/NAS) Q5XJ12 (/NAS) Q7ZYY3 (/NAS)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
2 P38646 (/HDA) P38646 (/HDA)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
2 P38646 (/IPI) P38646 (/IPI)
Unfolded protein binding GO:0051082
Interacting selectively and non-covalently with an unfolded protein.
2 P29845 (/ISS) P29845 (/ISS)
Unfolded protein binding GO:0051082
Interacting selectively and non-covalently with an unfolded protein.
2 P38646 (/TAS) P38646 (/TAS)
Fibroblast growth factor binding GO:0017134
Interacting selectively and non-covalently with a fibroblast growth factor.
1 P48721 (/IPI)
Fibroblast growth factor binding GO:0017134
Interacting selectively and non-covalently with a fibroblast growth factor.
1 P38647 (/ISO)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
1 P38647 (/IPI)
Heat shock protein binding GO:0031072
Interacting selectively and non-covalently with a heat shock protein, any protein synthesized or activated in response to heat shock.
1 P48721 (/IPI)
Heat shock protein binding GO:0031072
Interacting selectively and non-covalently with a heat shock protein, any protein synthesized or activated in response to heat shock.
1 P38647 (/ISO)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
1 P38647 (/ISO)
Chaperone binding GO:0051087
Interacting selectively and non-covalently with a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport.
1 P48721 (/IPI)
Chaperone binding GO:0051087
Interacting selectively and non-covalently with a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport.
1 P38647 (/ISO)

There are 38 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cellular response to cold GO:0070417
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.
87 P0A6Z1 (/IEP) P0A6Z1 (/IEP) P0A6Z1 (/IEP) P0A6Z1 (/IEP) P0A6Z1 (/IEP) P0A6Z1 (/IEP) P0A6Z1 (/IEP) P0A6Z1 (/IEP) P0A6Z1 (/IEP) P0A6Z1 (/IEP)
(77 more)
Protein maturation by iron-sulfur cluster transfer GO:0097428
The transfer of an assembled iron-sulfur cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein.
87 P0A6Z1 (/IDA) P0A6Z1 (/IDA) P0A6Z1 (/IDA) P0A6Z1 (/IDA) P0A6Z1 (/IDA) P0A6Z1 (/IDA) P0A6Z1 (/IDA) P0A6Z1 (/IDA) P0A6Z1 (/IDA) P0A6Z1 (/IDA)
(77 more)
Protein maturation by iron-sulfur cluster transfer GO:0097428
The transfer of an assembled iron-sulfur cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein.
87 P0A6Z1 (/IMP) P0A6Z1 (/IMP) P0A6Z1 (/IMP) P0A6Z1 (/IMP) P0A6Z1 (/IMP) P0A6Z1 (/IMP) P0A6Z1 (/IMP) P0A6Z1 (/IMP) P0A6Z1 (/IMP) P0A6Z1 (/IMP)
(77 more)
Protein folding GO:0006457
The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
8 P29845 (/ISS) P29845 (/ISS) Q9KTX8 (/ISS) Q9KTX8 (/ISS) Q9KTX8 (/ISS) Q9KTX8 (/ISS) Q9KTX8 (/ISS) Q9KTX8 (/ISS)
Erythrocyte differentiation GO:0030218
The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.
6 O35501 (/ISS) P38647 (/ISS) P48721 (/ISS) Q3ZCH0 (/ISS) Q5R511 (/ISS) Q5ZM98 (/ISS)
Regulation of erythrocyte differentiation GO:0045646
Any process that modulates the frequency, rate or extent of erythrocyte differentiation.
6 O35501 (/ISS) P38647 (/ISS) P48721 (/ISS) Q3ZCH0 (/ISS) Q5R511 (/ISS) Q5ZM98 (/ISS)
Negative regulation of erythrocyte differentiation GO:0045647
Any process that stops, prevents, or reduces the frequency, rate or extent of erythrocyte differentiation.
6 O35501 (/ISS) P38647 (/ISS) P48721 (/ISS) Q3ZCH0 (/ISS) Q5R511 (/ISS) Q5ZM98 (/ISS)
Iron-sulfur cluster assembly GO:0016226
The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.
5 O35501 (/ISS) P48721 (/ISS) Q3ZCH0 (/ISS) Q5R511 (/ISS) Q5ZM98 (/ISS)
Negative regulation of hematopoietic stem cell differentiation GO:1902037
Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell differentiation.
5 O35501 (/ISS) P48721 (/ISS) Q3ZCH0 (/ISS) Q5R511 (/ISS) Q5ZM98 (/ISS)
Negative regulation of hemopoiesis GO:1903707
Any process that stops, prevents or reduces the frequency, rate or extent of hemopoiesis.
5 O35501 (/ISS) P48721 (/ISS) Q3ZCH0 (/ISS) Q5R511 (/ISS) Q5ZM98 (/ISS)
Response to heat GO:0009408
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
4 Q5HV33 (/IDA) Q5HV33 (/IDA) Q5HV33 (/IDA) Q5HV33 (/IDA)
Posttranscriptional regulation of gene expression GO:0010608
Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript.
3 Q585X3 (/IDA) Q585X3 (/IDA) Q585X3 (/IDA)
Iron-sulfur cluster assembly GO:0016226
The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.
3 P38646 (/IMP) P38646 (/IMP) P38647 (/IMP)
Hemopoiesis GO:0030097
The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.
3 F1QFC0 (/IMP) Q5XJ12 (/IMP) Q7ZYY3 (/IMP)
Fin regeneration GO:0031101
The regrowth of fin tissue following its loss or destruction.
3 F1QFC0 (/IMP) Q5XJ12 (/IMP) Q7ZYY3 (/IMP)
Autophagy of mitochondrion GO:0000422
The autophagic process in which mitochondria are delivered to the vacuole and degraded in response to changing cellular conditions.
2 P29845 (/IMP) P29845 (/IMP)
Positive regulation of mitochondrial membrane potential GO:0010918
Any process that activates or increases the frequency, rate or extent of establishment or extent of a mitochondrial membrane potential, the electric potential existing across any mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
2 P29845 (/IMP) P29845 (/IMP)
Erythrocyte differentiation GO:0030218
The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.
2 P38646 (/IMP) P38646 (/IMP)
Interleukin-12-mediated signaling pathway GO:0035722
A series of molecular signals initiated by the binding of interleukin-12 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 P38646 (/TAS) P38646 (/TAS)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
2 P38646 (/TAS) P38646 (/TAS)
Regulation of erythrocyte differentiation GO:0045646
Any process that modulates the frequency, rate or extent of erythrocyte differentiation.
2 P38646 (/IMP) P38646 (/IMP)
Negative regulation of erythrocyte differentiation GO:0045647
Any process that stops, prevents, or reduces the frequency, rate or extent of erythrocyte differentiation.
2 P38646 (/IMP) P38646 (/IMP)
Mitochondrion morphogenesis GO:0070584
The process in which the anatomical structures of a mitochondrion are generated and organized.
2 P29845 (/IMP) P29845 (/IMP)
Protein export from nucleus GO:0006611
The directed movement of a protein from the nucleus into the cytoplasm.
1 P38647 (/IDA)
Response to toxic substance GO:0009636
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.
1 P48721 (/IEP)
Iron-sulfur cluster assembly GO:0016226
The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.
1 P38647 (/ISO)
Erythrocyte differentiation GO:0030218
The process in which a myeloid precursor cell acquires specializes features of an erythrocyte.
1 P38647 (/ISO)
Regulation of erythrocyte differentiation GO:0045646
Any process that modulates the frequency, rate or extent of erythrocyte differentiation.
1 P38647 (/ISO)
Negative regulation of erythrocyte differentiation GO:0045647
Any process that stops, prevents, or reduces the frequency, rate or extent of erythrocyte differentiation.
1 P38647 (/ISO)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
1 P48721 (/IDA)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
1 P38647 (/ISO)
Response to folic acid GO:0051593
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a folic acid stimulus.
1 P48721 (/IEP)
Negative regulation of cell death GO:0060548
Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
1 P48721 (/IDA)
Negative regulation of cell death GO:0060548
Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
1 P38647 (/ISO)
Cellular response to interleukin-1 GO:0071347
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.
1 P48721 (/IEP)
Response to thyroxine GO:0097068
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroxine stimulus.
1 P48721 (/IEP)
Negative regulation of hematopoietic stem cell differentiation GO:1902037
Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell differentiation.
1 P38647 (/IMP)
Negative regulation of hemopoiesis GO:1903707
Any process that stops, prevents or reduces the frequency, rate or extent of hemopoiesis.
1 P38647 (/IMP)

There are 19 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
87 P0A6Z1 (/IDA) P0A6Z1 (/IDA) P0A6Z1 (/IDA) P0A6Z1 (/IDA) P0A6Z1 (/IDA) P0A6Z1 (/IDA) P0A6Z1 (/IDA) P0A6Z1 (/IDA) P0A6Z1 (/IDA) P0A6Z1 (/IDA)
(77 more)
Iron-sulfur cluster transfer complex GO:1990230
A protein complex capable of catalyzing the transfer of an iron-sulfur (Fe-S) cluster from one compound (donor) to another (acceptor).
87 P0A6Z1 (/IDA) P0A6Z1 (/IDA) P0A6Z1 (/IDA) P0A6Z1 (/IDA) P0A6Z1 (/IDA) P0A6Z1 (/IDA) P0A6Z1 (/IDA) P0A6Z1 (/IDA) P0A6Z1 (/IDA) P0A6Z1 (/IDA)
(77 more)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
7 P38646 (/IDA) P38646 (/IDA) P38647 (/IDA) P48721 (/IDA) Q585X3 (/IDA) Q585X3 (/IDA) Q585X3 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
6 O35501 (/ISS) P29845 (/ISS) P29845 (/ISS) Q3ZCH0 (/ISS) Q5R511 (/ISS) Q5ZM98 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 P38646 (/TAS) P38646 (/TAS) P38647 (/TAS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
3 P29845 (/HDA) P29845 (/HDA) P38647 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
3 Q585X3 (/RCA) Q585X3 (/RCA) Q585X3 (/RCA)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
3 F1QFC0 (/NAS) Q5XJ12 (/NAS) Q7ZYY3 (/NAS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 P38646 (/TAS) P38646 (/TAS)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
2 P38646 (/TAS) P38646 (/TAS)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
2 P38646 (/HDA) P38646 (/HDA)
Mitochondrial nucleoid GO:0042645
The region of a mitochondrion to which the DNA is confined.
2 P38646 (/IDA) P38646 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
2 P38646 (/HDA) P38646 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P48721 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P38647 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 P38647 (/ISO)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
1 P38647 (/IDA)
Mitochondrial nucleoid GO:0042645
The region of a mitochondrion to which the DNA is confined.
1 P38647 (/ISO)
Myelin sheath GO:0043209
An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.
1 P38647 (/HDA)