The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Exopolyphosphatase. Domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Ectonucleoside triphosphate diphosphohydrolase 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleoside-diphosphatase activity GO:0017110
Catalysis of the reaction: a nucleoside diphosphate + H2O = a nucleotide + phosphate.
9 O55026 (/IDA) O55026 (/IDA) P55772 (/IDA) P55772 (/IDA) Q3TC04 (/IDA) Q3TDX3 (/IDA) Q8BFW6 (/IDA) Q8CCV2 (/IDA) Q8K0L2 (/IDA)
Nucleoside-triphosphatase activity GO:0017111
Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate.
9 O55026 (/IDA) O55026 (/IDA) P55772 (/IDA) P55772 (/IDA) Q3TC04 (/IDA) Q3TDX3 (/IDA) Q8BFW6 (/IDA) Q8CCV2 (/IDA) Q8K0L2 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 O55026 (/IPI) O55026 (/IPI) O75355 (/IPI) P49961 (/IPI)
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
4 A0A1D5PS27 (/IDA) O35795 (/IDA) P79784 (/IDA) P97687 (/IDA)
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
4 O55026 (/ISO) O55026 (/ISO) P55772 (/ISO) P55772 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
4 O55026 (/ISO) O55026 (/ISO) P55772 (/ISO) P55772 (/ISO)
Adenosine-diphosphatase activity GO:0043262
Catalysis of the reaction: ADP + H2O = AMP + phosphate.
4 O55026 (/ISO) O55026 (/ISO) P55772 (/ISO) P55772 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 O35795 (/IDA) P97687 (/IDA)
Adenosine-diphosphatase activity GO:0043262
Catalysis of the reaction: ADP + H2O = AMP + phosphate.
2 O35795 (/IDA) P97687 (/IDA)

There are 34 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Response to ethanol GO:0045471
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
8 E7FG27 (/IDA) F1Q7R9 (/IDA) F1QSE5 (/IDA) F1RDI7 (/IDA) Q66L64 (/IDA) Q6DC46 (/IDA) Q6ZM68 (/IDA) Q6ZM69 (/IDA)
Response to copper ion GO:0046688
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus.
8 E7FG27 (/IDA) F1Q7R9 (/IDA) F1QSE5 (/IDA) F1RDI7 (/IDA) Q66L64 (/IDA) Q6DC46 (/IDA) Q6ZM68 (/IDA) Q6ZM69 (/IDA)
Cellular response to methanol GO:0071405
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methanol stimulus.
5 E7FG27 (/IDA) F1Q7R9 (/IDA) F1QSE5 (/IDA) Q6DC46 (/IDA) Q6ZM69 (/IDA)
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
4 O55026 (/IDA) O55026 (/IDA) P55772 (/IDA) P55772 (/IDA)
Nucleoside diphosphate catabolic process GO:0009134
The chemical reactions and pathways resulting in the breakdown of a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar.
4 Q3TC04 (/IDA) Q3TDX3 (/IDA) Q8BFW6 (/IDA) Q8CCV2 (/IDA)
Nucleoside triphosphate catabolic process GO:0009143
The chemical reactions and pathways resulting in the breakdown of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar.
4 Q3TC04 (/IDA) Q3TDX3 (/IDA) Q8BFW6 (/IDA) Q8CCV2 (/IDA)
Purine ribonucleoside diphosphate catabolic process GO:0009181
The chemical reactions and pathways resulting in the breakdown of purine ribonucleoside diphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with diphosphate on the sugar.
4 O55026 (/IDA) O55026 (/IDA) P55772 (/IDA) P55772 (/IDA)
Platelet activation GO:0030168
A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.
4 O55026 (/IDA) O55026 (/IDA) P55772 (/IDA) P55772 (/IDA)
Nucleobase-containing small molecule catabolic process GO:0034656
The chemical reactions and pathways resulting in the breakdown of a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide.
4 O75355 (/TAS) P49961 (/TAS) Q5MY95 (/TAS) Q9Y5L3 (/TAS)
Protein homooligomerization GO:0051260
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
4 O55026 (/ISO) O55026 (/ISO) P55772 (/ISO) P55772 (/ISO)
Response to auditory stimulus GO:0010996
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auditory stimulus.
2 O35795 (/IEP) P97687 (/IEP)
Negative regulation of dopamine secretion GO:0033602
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of dopamine.
2 P55772 (/ISO) P55772 (/ISO)
Cellular response to interferon-alpha GO:0035457
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-alpha stimulus. Interferon-alpha is a type I interferon.
2 O35795 (/IEP) P97687 (/IEP)
Protein homooligomerization GO:0051260
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
2 O35795 (/IDA) P97687 (/IDA)
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
2 O35795 (/IEP) P97687 (/IEP)
Cellular response to interleukin-6 GO:0071354
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus.
2 O55026 (/ISO) O55026 (/ISO)
Cellular response to tumor necrosis factor GO:0071356
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
2 O35795 (/IEP) P97687 (/IEP)
Negative regulation of ATP biosynthetic process GO:2001170
Any process that stops, prevents or reduces the frequency, rate or extent of ATP biosynthetic process.
2 P55772 (/ISO) P55772 (/ISO)
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
1 P49961 (/NAS)
Blood coagulation GO:0007596
The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.
1 P49961 (/TAS)
Nucleoside monophosphate biosynthetic process GO:0009124
The chemical reactions and pathways resulting in the formation of a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar.
1 Q8K0L2 (/IDA)
Nucleoside diphosphate biosynthetic process GO:0009133
The chemical reactions and pathways resulting in the formation of a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar.
1 Q8K0L2 (/IDA)
Response to proline GO:0010238
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a proline stimulus.
1 P97687 (/IEP)
Response to gamma radiation GO:0010332
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum.
1 P97687 (/IEP)
Response to caffeine GO:0031000
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them.
1 P97687 (/IEP)
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
1 P97687 (/IEP)
Response to ATP GO:0033198
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus.
1 P97687 (/IEP)
Negative regulation of dopamine secretion GO:0033602
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of dopamine.
1 P97687 (/IMP)
Response to interferon-beta GO:0035456
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon.
1 P97687 (/IEP)
Response to morphine GO:0043278
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a morphine stimulus. Morphine is an opioid alkaloid, isolated from opium, with a complex ring structure.
1 P97687 (/IEP)
Cellular response to aluminum ion GO:0071275
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aluminum ion stimulus.
1 P97687 (/IEP)
Cellular response to interleukin-6 GO:0071354
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus.
1 O35795 (/IMP)
Response to L-arginine GO:1903576
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-arginine stimulus.
1 P97687 (/IEP)
Negative regulation of ATP biosynthetic process GO:2001170
Any process that stops, prevents or reduces the frequency, rate or extent of ATP biosynthetic process.
1 P97687 (/IMP)

There are 29 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
7 O35795 (/IDA) O55026 (/IDA) O55026 (/IDA) Q3TC04 (/IDA) Q3TDX3 (/IDA) Q8BFW6 (/IDA) Q8CCV2 (/IDA)
Basement membrane GO:0005604
A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.
4 O55026 (/IDA) O55026 (/IDA) P55772 (/IDA) P55772 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 O75355 (/TAS) P49961 (/TAS) Q5MY95 (/TAS) Q9Y5L3 (/TAS)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
4 O55026 (/ISO) O55026 (/ISO) P55772 (/ISO) P55772 (/ISO)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 P55772 (/ISO) P55772 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 O55026 (/ISO) O55026 (/ISO)
Synaptic vesicle GO:0008021
A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
2 P55772 (/ISO) P55772 (/ISO)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
2 O35795 (/IDA) P97687 (/IDA)
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
2 P55772 (/ISO) P55772 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 P79784 (/IDA) Q8K0L2 (/IDA)
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
2 P55772 (/ISO) P55772 (/ISO)
Cell projection membrane GO:0031253
The portion of the plasma membrane surrounding a plasma membrane bounded cell surface projection.
2 O55026 (/ISO) O55026 (/ISO)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
2 P55772 (/ISO) P55772 (/ISO)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
2 P55772 (/ISO) P55772 (/ISO)
Cell body GO:0044297
The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.
2 O55026 (/ISO) O55026 (/ISO)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
2 P49961 (/HDA) Q9Y5L3 (/HDA)
Synaptic membrane GO:0097060
A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
2 P55772 (/ISO) P55772 (/ISO)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 P97687 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P49961 (/NAS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P49961 (/TAS)
Synaptic vesicle GO:0008021
A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
1 P97687 (/IDA)
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
1 P97687 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 P49961 (/HDA)
Basolateral plasma membrane GO:0016323
The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
1 P97687 (/IDA)
Cell projection membrane GO:0031253
The portion of the plasma membrane surrounding a plasma membrane bounded cell surface projection.
1 O35795 (/IDA)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 P97687 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 P97687 (/IDA)
Cell body GO:0044297
The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.
1 O35795 (/IDA)
Synaptic membrane GO:0097060
A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
1 P97687 (/IDA)