The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Ribonuclease H-like superfamily/Ribonuclease H
".
FunFam 65: Protein RRP6-like 2 isoform A
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 2 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
3'-5'-exoribonuclease activity GO:0000175
Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule.
|
2 | Q0WVE8 (/IMP) Q0WVE8 (/IMP) |
|
Single-stranded RNA binding GO:0003727
Interacting selectively and non-covalently with single-stranded RNA.
|
1 | F4HWX0 (/IDA) |
There are 9 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
RNA-directed DNA methylation GO:0080188
An epigenetic RNA-based gene silencing process first elucidated in plants whereby 24-nt small interfering RNAs (siRNAs) guide DNA methyltransferases to the siRNA-generating genomic loci and other loci that are homologous to the siRNAs for de novo DNA methylation. In general this process consists of three phases: biogenesis of siRNAs, scaffold RNA production, and the formation of the guiding complex that recruits de novo DNA methyltransferases to the target loci.
|
4 | A9LLI7 (/IMP) F4HWX0 (/IMP) Q0WVE8 (/IMP) Q0WVE8 (/IMP) |
|
Positive regulation of histone H3-K27 trimethylation GO:1902466
Any process that activates or increases the frequency, rate or extent of histone H3-K27 trimethylation.
|
3 | A9LLI7 (/IMP) Q0WVE8 (/IMP) Q0WVE8 (/IMP) |
|
Methylation-dependent chromatin silencing GO:0006346
Repression of transcription by methylation of DNA, leading to the formation of heterochromatin.
|
1 | F4HWX0 (/IMP) |
|
RRNA processing GO:0006364
Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.
|
1 | A9LLI7 (/IMP) |
|
Polyadenylation-dependent RNA catabolic process GO:0043633
The chemical reactions and pathways resulting in the breakdown of an RNA molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3'-end of the target RNA.
|
1 | A9LLI7 (/IMP) |
|
Regulation of DNA methylation GO:0044030
Any process that modulates the frequency, rate or extent of the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine.
|
1 | F4HWX0 (/IMP) |
|
Positive regulation of production of siRNA involved in RNA interference GO:1903705
Any process that activates or increases the frequency, rate or extent of production of siRNA involved in RNA interference.
|
1 | F4HWX0 (/IMP) |
|
Positive regulation of transcription by RNA polymerase V GO:1904281
Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase V.
|
1 | F4HWX0 (/IMP) |
|
RNA localization to chromatin GO:1990280
A process in which RNA is transported to and maintained in a part of a chromosome that is organized into chromatin.
|
1 | F4HWX0 (/IMP) |
There are 5 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
3 | A9LLI7 (/IDA) Q0WVE8 (/IDA) Q0WVE8 (/IDA) |
|
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
|
3 | A9LLI7 (/IDA) Q0WVE8 (/IDA) Q0WVE8 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | F4HWX0 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | A9LLI7 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | A9LLI7 (/IDA) |