The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Ribonuclease H-like superfamily/Ribonuclease H
".
FunFam 5: CCR4-NOT transcription complex subunit 7
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 16 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
167 |
B3DMA5 (/IPI)
B3DMA5 (/IPI)
B3DMA5 (/IPI)
B3DMA5 (/IPI)
B3DMA5 (/IPI)
B3DMA5 (/IPI)
B3DMA5 (/IPI)
E1JHY7 (/IPI)
Q60809 (/IPI)
Q60809 (/IPI)
(157 more) |
|
Poly(A)-specific ribonuclease activity GO:0004535
Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP.
|
156 |
E1JHY7 (/IDA)
Q8I0I5 (/IDA)
Q8IGD6 (/IDA)
Q9UFF9 (/IDA)
Q9UFF9 (/IDA)
Q9UFF9 (/IDA)
Q9UFF9 (/IDA)
Q9UFF9 (/IDA)
Q9UFF9 (/IDA)
Q9UFF9 (/IDA)
(146 more) |
|
3'-5'-exoribonuclease activity GO:0000175
Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule.
|
151 |
Q9UFF9 (/IDA)
Q9UFF9 (/IDA)
Q9UFF9 (/IDA)
Q9UFF9 (/IDA)
Q9UFF9 (/IDA)
Q9UFF9 (/IDA)
Q9UFF9 (/IDA)
Q9UFF9 (/IDA)
Q9UFF9 (/IDA)
Q9UFF9 (/IDA)
(141 more) |
|
3'-5'-exoribonuclease activity GO:0000175
Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule.
|
118 |
A4II96 (/ISS)
Q08BM8 (/ISS)
Q3KQ85 (/ISS)
Q3KQ85 (/ISS)
Q3ZC01 (/ISS)
Q3ZC01 (/ISS)
Q3ZC01 (/ISS)
Q3ZC01 (/ISS)
Q3ZC01 (/ISS)
Q3ZC01 (/ISS)
(108 more) |
|
Exoribonuclease activity GO:0004532
Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of an RNA molecule.
|
117 |
A4II96 (/ISS)
Q08BM8 (/ISS)
Q3KQ85 (/ISS)
Q3KQ85 (/ISS)
Q3ZC01 (/ISS)
Q3ZC01 (/ISS)
Q3ZC01 (/ISS)
Q3ZC01 (/ISS)
Q3ZC01 (/ISS)
Q3ZC01 (/ISS)
(107 more) |
|
Poly(A)-specific ribonuclease activity GO:0004535
Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP.
|
111 |
A4II96 (/ISS)
Q08BM8 (/ISS)
Q3KQ85 (/ISS)
Q3KQ85 (/ISS)
Q3ZC01 (/ISS)
Q3ZC01 (/ISS)
Q3ZC01 (/ISS)
Q3ZC01 (/ISS)
Q3ZC01 (/ISS)
Q3ZC01 (/ISS)
(101 more) |
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
99 |
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
(89 more) |
|
Exoribonuclease activity GO:0004532
Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of an RNA molecule.
|
99 |
Q9UIV1 (/IDA)
Q9UIV1 (/IDA)
Q9UIV1 (/IDA)
Q9UIV1 (/IDA)
Q9UIV1 (/IDA)
Q9UIV1 (/IDA)
Q9UIV1 (/IDA)
Q9UIV1 (/IDA)
Q9UIV1 (/IDA)
Q9UIV1 (/IDA)
(89 more) |
|
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
99 |
Q9UIV1 (/IPI)
Q9UIV1 (/IPI)
Q9UIV1 (/IPI)
Q9UIV1 (/IPI)
Q9UIV1 (/IPI)
Q9UIV1 (/IPI)
Q9UIV1 (/IPI)
Q9UIV1 (/IPI)
Q9UIV1 (/IPI)
Q9UIV1 (/IPI)
(89 more) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
52 |
Q9UFF9 (/NAS)
Q9UFF9 (/NAS)
Q9UFF9 (/NAS)
Q9UFF9 (/NAS)
Q9UFF9 (/NAS)
Q9UFF9 (/NAS)
Q9UFF9 (/NAS)
Q9UFF9 (/NAS)
Q9UFF9 (/NAS)
Q9UFF9 (/NAS)
(42 more) |
|
3'-5'-exoribonuclease activity GO:0000175
Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule.
|
8 | Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q9D8X5 (/ISO) |
|
Poly(A)-specific ribonuclease activity GO:0004535
Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP.
|
8 | Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q9D8X5 (/ISO) |
|
Transcription corepressor activity GO:0003714
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A fourth class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators.
|
7 | Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) |
|
Exoribonuclease activity GO:0004532
Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of an RNA molecule.
|
7 | Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) |
|
Poly(A)-specific ribonuclease activity GO:0004535
Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP.
|
7 | Q60809 (/IMP) Q60809 (/IMP) Q60809 (/IMP) Q60809 (/IMP) Q60809 (/IMP) Q60809 (/IMP) Q60809 (/IMP) |
|
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
7 | Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) |
There are 47 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Gene silencing by RNA GO:0031047
Any process in which RNA molecules inactivate expression of target genes.
|
209 |
A4II96 (/ISS)
Q08BM8 (/ISS)
Q3KQ85 (/ISS)
Q3KQ85 (/ISS)
Q3ZC01 (/ISS)
Q3ZC01 (/ISS)
Q3ZC01 (/ISS)
Q3ZC01 (/ISS)
Q3ZC01 (/ISS)
Q3ZC01 (/ISS)
(199 more) |
|
Nuclear-transcribed mRNA poly(A) tail shortening GO:0000289
Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length.
|
151 |
Q9UFF9 (/TAS)
Q9UFF9 (/TAS)
Q9UFF9 (/TAS)
Q9UFF9 (/TAS)
Q9UFF9 (/TAS)
Q9UFF9 (/TAS)
Q9UFF9 (/TAS)
Q9UFF9 (/TAS)
Q9UFF9 (/TAS)
Q9UFF9 (/TAS)
(141 more) |
|
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977
A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the stopping or reduction in rate of the cell cycle.
|
151 |
Q9UFF9 (/TAS)
Q9UFF9 (/TAS)
Q9UFF9 (/TAS)
Q9UFF9 (/TAS)
Q9UFF9 (/TAS)
Q9UFF9 (/TAS)
Q9UFF9 (/TAS)
Q9UFF9 (/TAS)
Q9UFF9 (/TAS)
Q9UFF9 (/TAS)
(141 more) |
|
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
151 |
Q9UFF9 (/IMP)
Q9UFF9 (/IMP)
Q9UFF9 (/IMP)
Q9UFF9 (/IMP)
Q9UFF9 (/IMP)
Q9UFF9 (/IMP)
Q9UFF9 (/IMP)
Q9UFF9 (/IMP)
Q9UFF9 (/IMP)
Q9UFF9 (/IMP)
(141 more) |
|
Gene silencing by miRNA GO:0035195
Downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: endolytic cleavage of the RNA (often mRNA) or mRNA translational repression, usually accompanied by poly-A tail shortening and subsequent degradation of the mRNA.
|
151 |
Q9UFF9 (/TAS)
Q9UFF9 (/TAS)
Q9UFF9 (/TAS)
Q9UFF9 (/TAS)
Q9UFF9 (/TAS)
Q9UFF9 (/TAS)
Q9UFF9 (/TAS)
Q9UFF9 (/TAS)
Q9UFF9 (/TAS)
Q9UFF9 (/TAS)
(141 more) |
|
Exonucleolytic catabolism of deadenylated mRNA GO:0043928
The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 3'-poly(A) tail.
|
151 |
Q9UFF9 (/IDA)
Q9UFF9 (/IDA)
Q9UFF9 (/IDA)
Q9UFF9 (/IDA)
Q9UFF9 (/IDA)
Q9UFF9 (/IDA)
Q9UFF9 (/IDA)
Q9UFF9 (/IDA)
Q9UFF9 (/IDA)
Q9UFF9 (/IDA)
(141 more) |
|
Positive regulation of mRNA catabolic process GO:0061014
Any process that increases the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
|
151 |
Q9UFF9 (/IMP)
Q9UFF9 (/IMP)
Q9UFF9 (/IMP)
Q9UFF9 (/IMP)
Q9UFF9 (/IMP)
Q9UFF9 (/IMP)
Q9UFF9 (/IMP)
Q9UFF9 (/IMP)
Q9UFF9 (/IMP)
Q9UFF9 (/IMP)
(141 more) |
|
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
118 |
A4II96 (/ISS)
Q08BM8 (/ISS)
Q3KQ85 (/ISS)
Q3KQ85 (/ISS)
Q3ZC01 (/ISS)
Q3ZC01 (/ISS)
Q3ZC01 (/ISS)
Q3ZC01 (/ISS)
Q3ZC01 (/ISS)
Q3ZC01 (/ISS)
(108 more) |
|
Exonucleolytic catabolism of deadenylated mRNA GO:0043928
The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 3'-poly(A) tail.
|
118 |
A4II96 (/ISS)
Q08BM8 (/ISS)
Q3KQ85 (/ISS)
Q3KQ85 (/ISS)
Q3ZC01 (/ISS)
Q3ZC01 (/ISS)
Q3ZC01 (/ISS)
Q3ZC01 (/ISS)
Q3ZC01 (/ISS)
Q3ZC01 (/ISS)
(108 more) |
|
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
117 |
A4II96 (/ISS)
Q08BM8 (/ISS)
Q3KQ85 (/ISS)
Q3KQ85 (/ISS)
Q3ZC01 (/ISS)
Q3ZC01 (/ISS)
Q3ZC01 (/ISS)
Q3ZC01 (/ISS)
Q3ZC01 (/ISS)
Q3ZC01 (/ISS)
(107 more) |
|
Positive regulation of nuclear-transcribed mRNA poly(A) tail shortening GO:0060213
Any process that increases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length.
|
117 |
A4II96 (/ISS)
Q08BM8 (/ISS)
Q3KQ85 (/ISS)
Q3KQ85 (/ISS)
Q3ZC01 (/ISS)
Q3ZC01 (/ISS)
Q3ZC01 (/ISS)
Q3ZC01 (/ISS)
Q3ZC01 (/ISS)
Q3ZC01 (/ISS)
(107 more) |
|
Positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:1900153
Any process that activates or increases the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay.
|
117 |
A4II96 (/ISS)
Q08BM8 (/ISS)
Q3KQ85 (/ISS)
Q3KQ85 (/ISS)
Q3ZC01 (/ISS)
Q3ZC01 (/ISS)
Q3ZC01 (/ISS)
Q3ZC01 (/ISS)
Q3ZC01 (/ISS)
Q3ZC01 (/ISS)
(107 more) |
|
Positive regulation of nuclear-transcribed mRNA poly(A) tail shortening GO:0060213
Any process that increases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length.
|
106 |
Q60809 (/IMP)
Q60809 (/IMP)
Q60809 (/IMP)
Q60809 (/IMP)
Q60809 (/IMP)
Q60809 (/IMP)
Q60809 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
(96 more) |
|
Positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:1900153
Any process that activates or increases the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay.
|
106 |
Q60809 (/IMP)
Q60809 (/IMP)
Q60809 (/IMP)
Q60809 (/IMP)
Q60809 (/IMP)
Q60809 (/IMP)
Q60809 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
(96 more) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
99 |
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
(89 more) |
|
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
99 |
Q9UIV1 (/IDA)
Q9UIV1 (/IDA)
Q9UIV1 (/IDA)
Q9UIV1 (/IDA)
Q9UIV1 (/IDA)
Q9UIV1 (/IDA)
Q9UIV1 (/IDA)
Q9UIV1 (/IDA)
Q9UIV1 (/IDA)
Q9UIV1 (/IDA)
(89 more) |
|
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
99 |
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
(89 more) |
|
Regulation of tyrosine phosphorylation of STAT protein GO:0042509
Any process that modulates the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
|
99 |
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
(89 more) |
|
Positive regulation of viral genome replication GO:0045070
Any process that activates or increases the frequency, rate or extent of viral genome replication.
|
99 |
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
(89 more) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
99 |
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
(89 more) |
|
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
|
99 |
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
(89 more) |
|
Negative regulation of type I interferon-mediated signaling pathway GO:0060339
Any process that decreases the rate, frequency or extent of a type I interferon-mediated signaling pathway. A type I interferon-mediated signaling pathway is the series of molecular events generated as a consequence of a type I interferon binding to a cell surface receptor.
|
99 |
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
(89 more) |
|
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
|
52 |
Q9UFF9 (/NAS)
Q9UFF9 (/NAS)
Q9UFF9 (/NAS)
Q9UFF9 (/NAS)
Q9UFF9 (/NAS)
Q9UFF9 (/NAS)
Q9UFF9 (/NAS)
Q9UFF9 (/NAS)
Q9UFF9 (/NAS)
Q9UFF9 (/NAS)
(42 more) |
|
Nuclear-transcribed mRNA poly(A) tail shortening GO:0000289
Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length.
|
12 |
E1JHY7 (/IMP)
Q60809 (/IMP)
Q60809 (/IMP)
Q60809 (/IMP)
Q60809 (/IMP)
Q60809 (/IMP)
Q60809 (/IMP)
Q60809 (/IMP)
Q8I0I5 (/IMP)
Q8IGD6 (/IMP)
(2 more) |
|
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
8 | Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q9D8X5 (/ISO) |
|
Exonucleolytic catabolism of deadenylated mRNA GO:0043928
The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 3'-poly(A) tail.
|
8 | Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q9D8X5 (/ISO) |
|
Positive regulation of mRNA catabolic process GO:0061014
Any process that increases the rate, frequency, or extent of a mRNA catabolic process, the chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
|
8 | Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q9D8X5 (/ISO) |
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
7 | Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) |
|
Deadenylation-dependent decapping of nuclear-transcribed mRNA GO:0000290
Cleavage of the 5'-cap of a nuclear mRNA triggered by shortening of the poly(A) tail to below a minimum functional length.
|
7 | Q60809 (/IGI) Q60809 (/IGI) Q60809 (/IGI) Q60809 (/IGI) Q60809 (/IGI) Q60809 (/IGI) Q60809 (/IGI) |
|
Deadenylation-dependent decapping of nuclear-transcribed mRNA GO:0000290
Cleavage of the 5'-cap of a nuclear mRNA triggered by shortening of the poly(A) tail to below a minimum functional length.
|
7 | Q60809 (/IMP) Q60809 (/IMP) Q60809 (/IMP) Q60809 (/IMP) Q60809 (/IMP) Q60809 (/IMP) Q60809 (/IMP) |
|
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
|
7 | Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) |
|
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
7 | Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) |
|
Gene silencing by RNA GO:0031047
Any process in which RNA molecules inactivate expression of target genes.
|
7 | Q60809 (/IMP) Q60809 (/IMP) Q60809 (/IMP) Q60809 (/IMP) Q60809 (/IMP) Q60809 (/IMP) Q60809 (/IMP) |
|
Cytoplasmic mRNA processing body assembly GO:0033962
The aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body.
|
7 | Q60809 (/IGI) Q60809 (/IGI) Q60809 (/IGI) Q60809 (/IGI) Q60809 (/IGI) Q60809 (/IGI) Q60809 (/IGI) |
|
Regulation of tyrosine phosphorylation of STAT protein GO:0042509
Any process that modulates the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
|
7 | Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) |
|
Positive regulation of viral genome replication GO:0045070
Any process that activates or increases the frequency, rate or extent of viral genome replication.
|
7 | Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
7 | Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
7 | Q60809 (/IDA) Q60809 (/IDA) Q60809 (/IDA) Q60809 (/IDA) Q60809 (/IDA) Q60809 (/IDA) Q60809 (/IDA) |
|
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
|
7 | Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) |
|
Positive regulation of nuclear-transcribed mRNA poly(A) tail shortening GO:0060213
Any process that increases the frequency, rate or extent of poly(A) tail shortening of a nuclear-transcribed mRNA. Poly(A) tail shortening is the decrease in length of the poly(A) tail of an mRNA from full length to an oligo(A) length.
|
7 | Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) |
|
Negative regulation of type I interferon-mediated signaling pathway GO:0060339
Any process that decreases the rate, frequency or extent of a type I interferon-mediated signaling pathway. A type I interferon-mediated signaling pathway is the series of molecular events generated as a consequence of a type I interferon binding to a cell surface receptor.
|
7 | Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) |
|
Positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:1900153
Any process that activates or increases the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay.
|
7 | Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) |
|
MRNA catabolic process GO:0006402
The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.
|
5 | E1JHY7 (/IDA) Q8I0I5 (/IDA) Q8IGD6 (/IDA) Q9VTS4 (/IDA) X2JCC3 (/IDA) |
|
Negative regulation of translation GO:0017148
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
|
5 | E1JHY7 (/IDA) Q8I0I5 (/IDA) Q8IGD6 (/IDA) Q9VTS4 (/IDA) X2JCC3 (/IDA) |
|
Neuron development GO:0048666
The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
|
2 | A8E5K6 (/IGI) Q7SXS5 (/IGI) |
|
Neuron development GO:0048666
The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
|
2 | A8E5K6 (/IMP) Q7SXS5 (/IMP) |
|
MRNA catabolic process GO:0006402
The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.
|
1 | Q08BM8 (/IMP) |
There are 23 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
165 |
B3DMA5 (/IDA)
B3DMA5 (/IDA)
B3DMA5 (/IDA)
B3DMA5 (/IDA)
B3DMA5 (/IDA)
B3DMA5 (/IDA)
B3DMA5 (/IDA)
Q60809 (/IDA)
Q60809 (/IDA)
Q60809 (/IDA)
(155 more) |
|
CCR4-NOT complex GO:0030014
The evolutionarily conserved CCR4-NOT complex is involved in several aspects of mRNA metabolism, including repression and activation of mRNA initiation, control of mRNA elongation, and the deadenylation and subsequent degradation of mRNA. In Saccharomyces the CCR4-NOT complex comprises a core complex of 9 proteins (Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p), Caf4p, Caf16p, and several less well characterized proteins.
|
156 |
E1JHY7 (/IDA)
Q8I0I5 (/IDA)
Q8IGD6 (/IDA)
Q9UFF9 (/IDA)
Q9UFF9 (/IDA)
Q9UFF9 (/IDA)
Q9UFF9 (/IDA)
Q9UFF9 (/IDA)
Q9UFF9 (/IDA)
Q9UFF9 (/IDA)
(146 more) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
151 |
Q9UFF9 (/TAS)
Q9UFF9 (/TAS)
Q9UFF9 (/TAS)
Q9UFF9 (/TAS)
Q9UFF9 (/TAS)
Q9UFF9 (/TAS)
Q9UFF9 (/TAS)
Q9UFF9 (/TAS)
Q9UFF9 (/TAS)
Q9UFF9 (/TAS)
(141 more) |
|
CCR4-NOT complex GO:0030014
The evolutionarily conserved CCR4-NOT complex is involved in several aspects of mRNA metabolism, including repression and activation of mRNA initiation, control of mRNA elongation, and the deadenylation and subsequent degradation of mRNA. In Saccharomyces the CCR4-NOT complex comprises a core complex of 9 proteins (Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p), Caf4p, Caf16p, and several less well characterized proteins.
|
111 |
A4II96 (/ISS)
Q08BM8 (/ISS)
Q3KQ85 (/ISS)
Q3KQ85 (/ISS)
Q3ZC01 (/ISS)
Q3ZC01 (/ISS)
Q3ZC01 (/ISS)
Q3ZC01 (/ISS)
Q3ZC01 (/ISS)
Q3ZC01 (/ISS)
(101 more) |
|
P-body GO:0000932
A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.
|
106 |
Q3ZC01 (/ISS)
Q3ZC01 (/ISS)
Q3ZC01 (/ISS)
Q3ZC01 (/ISS)
Q3ZC01 (/ISS)
Q3ZC01 (/ISS)
Q3ZC01 (/ISS)
Q9UIV1 (/ISS)
Q9UIV1 (/ISS)
Q9UIV1 (/ISS)
(96 more) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
99 |
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
(89 more) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
99 |
Q9UIV1 (/HDA)
Q9UIV1 (/HDA)
Q9UIV1 (/HDA)
Q9UIV1 (/HDA)
Q9UIV1 (/HDA)
Q9UIV1 (/HDA)
Q9UIV1 (/HDA)
Q9UIV1 (/HDA)
Q9UIV1 (/HDA)
Q9UIV1 (/HDA)
(89 more) |
|
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
|
99 |
Q9UIV1 (/IDA)
Q9UIV1 (/IDA)
Q9UIV1 (/IDA)
Q9UIV1 (/IDA)
Q9UIV1 (/IDA)
Q9UIV1 (/IDA)
Q9UIV1 (/IDA)
Q9UIV1 (/IDA)
Q9UIV1 (/IDA)
Q9UIV1 (/IDA)
(89 more) |
|
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
|
99 |
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
(89 more) |
|
CCR4-NOT complex GO:0030014
The evolutionarily conserved CCR4-NOT complex is involved in several aspects of mRNA metabolism, including repression and activation of mRNA initiation, control of mRNA elongation, and the deadenylation and subsequent degradation of mRNA. In Saccharomyces the CCR4-NOT complex comprises a core complex of 9 proteins (Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p), Caf4p, Caf16p, and several less well characterized proteins.
|
99 |
Q9UIV1 (/NAS)
Q9UIV1 (/NAS)
Q9UIV1 (/NAS)
Q9UIV1 (/NAS)
Q9UIV1 (/NAS)
Q9UIV1 (/NAS)
Q9UIV1 (/NAS)
Q9UIV1 (/NAS)
Q9UIV1 (/NAS)
Q9UIV1 (/NAS)
(89 more) |
|
Host cell PML body GO:0075341
A nuclear body that reacts against SP100 auto-antibodies (PML = promyelocytic leukemia) located within a cell of a host organism.
|
99 |
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
Q9UIV1 (/IMP)
(89 more) |
|
Intracellular GO:0005622
The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm.
|
52 |
Q9UFF9 (/IDA)
Q9UFF9 (/IDA)
Q9UFF9 (/IDA)
Q9UFF9 (/IDA)
Q9UFF9 (/IDA)
Q9UFF9 (/IDA)
Q9UFF9 (/IDA)
Q9UFF9 (/IDA)
Q9UFF9 (/IDA)
Q9UFF9 (/IDA)
(42 more) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
52 |
Q9UFF9 (/NAS)
Q9UFF9 (/NAS)
Q9UFF9 (/NAS)
Q9UFF9 (/NAS)
Q9UFF9 (/NAS)
Q9UFF9 (/NAS)
Q9UFF9 (/NAS)
Q9UFF9 (/NAS)
Q9UFF9 (/NAS)
Q9UFF9 (/NAS)
(42 more) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
12 |
E1JHY7 (/IDA)
Q60809 (/IDA)
Q60809 (/IDA)
Q60809 (/IDA)
Q60809 (/IDA)
Q60809 (/IDA)
Q60809 (/IDA)
Q60809 (/IDA)
Q8I0I5 (/IDA)
Q8IGD6 (/IDA)
(2 more) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
8 | Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q9D8X5 (/ISO) |
|
CCR4-NOT complex GO:0030014
The evolutionarily conserved CCR4-NOT complex is involved in several aspects of mRNA metabolism, including repression and activation of mRNA initiation, control of mRNA elongation, and the deadenylation and subsequent degradation of mRNA. In Saccharomyces the CCR4-NOT complex comprises a core complex of 9 proteins (Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p), Caf4p, Caf16p, and several less well characterized proteins.
|
8 | Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q9D8X5 (/ISO) |
|
P-body GO:0000932
A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.
|
7 | Q60809 (/IDA) Q60809 (/IDA) Q60809 (/IDA) Q60809 (/IDA) Q60809 (/IDA) Q60809 (/IDA) Q60809 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
7 | Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) |
|
Nuclear body GO:0016604
Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins.
|
7 | Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) |
|
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
|
7 | Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) |
|
CCR4-NOT complex GO:0030014
The evolutionarily conserved CCR4-NOT complex is involved in several aspects of mRNA metabolism, including repression and activation of mRNA initiation, control of mRNA elongation, and the deadenylation and subsequent degradation of mRNA. In Saccharomyces the CCR4-NOT complex comprises a core complex of 9 proteins (Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p), Caf4p, Caf16p, and several less well characterized proteins.
|
7 | Q60809 (/IPI) Q60809 (/IPI) Q60809 (/IPI) Q60809 (/IPI) Q60809 (/IPI) Q60809 (/IPI) Q60809 (/IPI) |
|
Host cell PML body GO:0075341
A nuclear body that reacts against SP100 auto-antibodies (PML = promyelocytic leukemia) located within a cell of a host organism.
|
7 | Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) Q60809 (/ISO) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
5 | E1JHY7 (/HDA) Q8I0I5 (/HDA) Q8IGD6 (/HDA) Q9VTS4 (/HDA) X2JCC3 (/HDA) |