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CATH Superfamily 3.30.360.30

homospermidine synthase like

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
homospermidine synthase like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily EC Annotations

Note: the EC figure is not being displayed for this superfamily as there are more than 100 different EC terms.

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Homospermidine synthase. [EC: 2.5.1.44]
(1) 2 putrescine = sym-homospermidine + NH(3) + H(+). (2) Putrescine + spermidine = sym-homospermidine + propane-1,3-diamine.
  • The reaction of this enzyme occurs in three steps, with some of the intermediates presumably remaining enzyme-bound: NAD(+)-dependent dehydrogenation of putrescine, transfer of the 4-aminobutylidene group from dehydroputrescine to a second molecule of putrescine and reduction of the imine intermediate to form homospermidine.
  • Hence the overall reaction is transfer of a 4-aminobutyl group.
  • Differs from EC 2.5.1.45, which cannot use putrescine as donor of the aminobutyl group.
 2 O32323 Q98H64