The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: K homology (KH) domain

This entry represents the KH domain, which is an RNA-binding domain important for post-translational activities DOI:10.1016/B978-0-12-809633-8.20662-6. A conserved glycine-rich GXXG motif is characteristic of the majority of KH domains. The KH domain contains three alpha-helices and a three-stranded anti-parallel beta-sheet PMID:27166440. There are two different versions of the KH motif, type I (commonly found in eukaryotic proteins) and type II (commonly found in prokaryotic proteins) PMID:18422648. The prokaryotic KH domain has been found in a number of proteins, including the N-terminal domain of the S3 ribosomal protein PMID:11014182, the C-terminal domain of Era GTPase PMID:10411886 and the two C-terminal domains of the NusA transcription factor PMID:11430821.

PMID:27166440 PMID:11014182 PMID:10411886 PMID:11430821

GO Diversity

Unique GO annotations
154 Unique GO terms

EC Diversity

Unique EC annotations
2 Unique EC terms

Species Diversity

Unique species annotations
25202 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 529
Domain clusters (>95% seq id): 58
Domain clusters (>35% seq id): 30
Unique PDBs: 470
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 83
Function
Unique EC: 2
Unique GO: 154
Taxonomy
Unique Species: 25202