The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

Type II secretion system, protein E, N-terminal domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Type II secretion system, protein E, N-terminal domain

This superfamily includes the N-terminal domain of type II secretion system protein E. Gram-negative bacteria use type II secretion systems for the transport of virulence factors and hydrolytic enzymes through the outer membrane. Proteins in this superfamily are typically involved in Type IV pilus biogenesis (e.g. Q9X4G8), though some are involved in other processes; for instance aggregation in Myxococcus xanthus (e.g. Q9RF11) PMID:11073903. The N-terminal domain has an alpha+beta conformation consisting of three alpha-helices and three beta-strands.

PFAM:PF05157, INTERPRO:IPR007831,DOI:10.1016/j.jmb.2005.02.061

GO Diversity

Unique GO annotations
13 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
7035 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 7
Domain clusters (>95% seq id): 3
Domain clusters (>35% seq id): 2
Unique PDBs: 4
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 25
Unique EC:
Unique GO: 13
Unique Species: 7035