The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Pseudouridine synthase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: H/ACA ribonucleoprotein complex subunit CBF5

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 26 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
9 O60832 (/IPI) O60832 (/IPI) O60832 (/IPI) P33322 (/IPI) P40615 (/IPI) Q57612 (/IPI) Q7LWY0 (/IPI) Q7LWY0 (/IPI) Q9ESX5 (/IPI)
Pseudouridine synthase activity GO:0009982
Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5.
6 P40615 (/ISS) Q5ZJH9 (/ISS) Q9ESX5 (/ISS) Q9LD90 (/ISS) Q9LD90 (/ISS) Q9LD90 (/ISS)
Pseudouridine synthase activity GO:0009982
Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5.
4 O60832 (/IMP) O60832 (/IMP) O60832 (/IMP) P33322 (/IMP)
Telomerase activity GO:0003720
Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence.
3 O60832 (/IDA) O60832 (/IDA) O60832 (/IDA)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
3 O60832 (/HDA) O60832 (/HDA) O60832 (/HDA)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
3 O60832 (/IPI) O60832 (/IPI) O60832 (/IPI)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
3 O60832 (/TAS) O60832 (/TAS) O60832 (/TAS)
Pseudouridine synthase activity GO:0009982
Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5.
3 Q9LD90 (/TAS) Q9LD90 (/TAS) Q9LD90 (/TAS)
Box H/ACA snoRNA binding GO:0034513
Interacting selectively and non-covalently with box H/ACA small nucleolar RNA.
3 O60832 (/IPI) O60832 (/IPI) O60832 (/IPI)
Telomerase RNA binding GO:0070034
Interacting selectively and non-covalently with the telomerase RNA template.
3 O60832 (/IC) O60832 (/IC) O60832 (/IC)
Telomerase RNA binding GO:0070034
Interacting selectively and non-covalently with the telomerase RNA template.
3 O60832 (/IPI) O60832 (/IPI) O60832 (/IPI)
Pseudouridine synthase activity GO:0009982
Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5.
2 O14007 (/ISO) Q9ESX5 (/ISO)
Telomerase activity GO:0003720
Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence.
1 Q9ESX5 (/ISO)
Telomerase activity GO:0003720
Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence.
1 Q54T81 (/ISS)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
1 Q38CM1 (/ISM)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
1 Q9ESX5 (/ISO)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
1 Q54T81 (/ISS)
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
1 P33322 (/HDA)
Pseudouridylate synthase activity GO:0004730
Catalysis of the reaction: D-ribose 5-phosphate + uracil = H(2)O + pseudouridine 5'-phosphate.
1 O43100 (/ISA)
Pseudouridylate synthase activity GO:0004730
Catalysis of the reaction: D-ribose 5-phosphate + uracil = H(2)O + pseudouridine 5'-phosphate.
1 Q38CM1 (/ISM)
Pseudouridine synthase activity GO:0009982
Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5.
1 P33322 (/IDA)
Pseudouridine synthase activity GO:0009982
Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5.
1 P33322 (/ISA)
RRNA binding GO:0019843
Interacting selectively and non-covalently with ribosomal RNA.
1 O14007 (/ISO)
Box H/ACA snoRNA binding GO:0034513
Interacting selectively and non-covalently with box H/ACA small nucleolar RNA.
1 O14007 (/IC)
Box H/ACA snoRNA binding GO:0034513
Interacting selectively and non-covalently with box H/ACA small nucleolar RNA.
1 Q9ESX5 (/ISO)
Telomerase RNA binding GO:0070034
Interacting selectively and non-covalently with the telomerase RNA template.
1 Q9ESX5 (/ISO)

There are 53 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
RRNA processing GO:0006364
Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.
6 F1Q749 (/IMP) O44081 (/IMP) O44081 (/IMP) P33322 (/IMP) Q498Z9 (/IMP) Q7ZUT3 (/IMP)
Telomere maintenance via telomerase GO:0007004
The maintenance of proper telomeric length by the addition of telomeric repeats by telomerase.
4 O60832 (/TAS) O60832 (/TAS) O60832 (/TAS) Q5ZJH9 (/TAS)
Positive regulation of telomerase activity GO:0051973
Any process that activates or increases the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
4 O60832 (/IMP) O60832 (/IMP) O60832 (/IMP) Q9ESX5 (/IMP)
Enzyme-directed rRNA pseudouridine synthesis GO:0000455
The intramolecular conversion of uridine to pseudouridine during ribosome biogenesis where the enzyme specifies the site that becomes pseudouridylated without using a guide RNA.
3 O60832 (/IMP) O60832 (/IMP) O60832 (/IMP)
Enzyme-directed rRNA pseudouridine synthesis GO:0000455
The intramolecular conversion of uridine to pseudouridine during ribosome biogenesis where the enzyme specifies the site that becomes pseudouridylated without using a guide RNA.
3 P40615 (/ISS) Q5ZJH9 (/ISS) Q9ESX5 (/ISS)
RRNA processing GO:0006364
Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.
3 O60832 (/TAS) O60832 (/TAS) O60832 (/TAS)
RNA processing GO:0006396
Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules.
3 O60832 (/TAS) O60832 (/TAS) O60832 (/TAS)
Telomere maintenance via telomerase GO:0007004
The maintenance of proper telomeric length by the addition of telomeric repeats by telomerase.
3 O60832 (/IDA) O60832 (/IDA) O60832 (/IDA)
Telomere maintenance via telomerase GO:0007004
The maintenance of proper telomeric length by the addition of telomeric repeats by telomerase.
3 O60832 (/IMP) O60832 (/IMP) O60832 (/IMP)
Telomere maintenance via telomerase GO:0007004
The maintenance of proper telomeric length by the addition of telomeric repeats by telomerase.
3 P40615 (/ISS) Q5ZJH9 (/ISS) Q9ESX5 (/ISS)
RRNA pseudouridine synthesis GO:0031118
The intramolecular conversion of uridine to pseudouridine in an rRNA molecule.
3 O60832 (/TAS) O60832 (/TAS) O60832 (/TAS)
Definitive hemopoiesis GO:0060216
A second wave of blood cell production that, in vertebrates, generates long-term hemopoietic stem cells that continously provide erythroid, myeloid and lymphoid lineages throughout adulthood.
3 F1Q749 (/IGI) Q498Z9 (/IGI) Q7ZUT3 (/IGI)
Definitive hemopoiesis GO:0060216
A second wave of blood cell production that, in vertebrates, generates long-term hemopoietic stem cells that continously provide erythroid, myeloid and lymphoid lineages throughout adulthood.
3 F1Q749 (/IMP) Q498Z9 (/IMP) Q7ZUT3 (/IMP)
ScaRNA localization to Cajal body GO:0090666
A process in which a small Cajal body-specific RNA is transported to, or maintained in, a Cajal body.
3 O60832 (/IMP) O60832 (/IMP) O60832 (/IMP)
Telomerase RNA stabilization GO:0090669
Prevention of degradation of telomerase RNA (TERC) molecules.
3 O60832 (/IMP) O60832 (/IMP) O60832 (/IMP)
Positive regulation of establishment of protein localization to telomere GO:1904851
Any process that activates or increases the frequency, rate or extent of establishment of protein localization to telomere.
3 O60832 (/IMP) O60832 (/IMP) O60832 (/IMP)
Positive regulation of protein localization to Cajal body GO:1904871
Any process that activates or increases the frequency, rate or extent of protein localization to Cajal body.
3 O60832 (/HMP) O60832 (/HMP) O60832 (/HMP)
Regulation of telomerase RNA localization to Cajal body GO:1904872
Any process that modulates the frequency, rate or extent of telomerase RNA localization to Cajal body.
3 O60832 (/IMP) O60832 (/IMP) O60832 (/IMP)
Positive regulation of telomerase RNA localization to Cajal body GO:1904874
Any process that activates or increases the frequency, rate or extent of telomerase RNA localization to Cajal body.
3 O60832 (/HMP) O60832 (/HMP) O60832 (/HMP)
Positive regulation of telomerase RNA localization to Cajal body GO:1904874
Any process that activates or increases the frequency, rate or extent of telomerase RNA localization to Cajal body.
3 O60832 (/IMP) O60832 (/IMP) O60832 (/IMP)
RRNA modification GO:0000154
The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically.
2 P33322 (/IMP) Q38CM1 (/IMP)
Pseudouridine synthesis GO:0001522
The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs.
2 O44081 (/IMP) O44081 (/IMP)
Germ cell development GO:0007281
The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.
2 O44081 (/IMP) O44081 (/IMP)
RRNA pseudouridine synthesis GO:0031118
The intramolecular conversion of uridine to pseudouridine in an rRNA molecule.
2 P33322 (/IMP) Q9ESX5 (/IMP)
Wing disc development GO:0035220
Progression of the wing disc over time, from its initial formation through to its metamorphosis to form adult structures including the wing hinge, wing blade and pleura.
2 O44081 (/IMP) O44081 (/IMP)
Ribosome biogenesis GO:0042254
A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis.
2 O44081 (/IMP) O44081 (/IMP)
SnoRNA guided rRNA pseudouridine synthesis GO:0000454
The intramolecular conversion of uridine to pseudouridine in an rRNA molecule during ribosome biogenesis using a snoRNA guide that targets the position of pseudouridylation.
1 P40615 (/IDA)
SnoRNA guided rRNA pseudouridine synthesis GO:0000454
The intramolecular conversion of uridine to pseudouridine in an rRNA molecule during ribosome biogenesis using a snoRNA guide that targets the position of pseudouridylation.
1 Q9ESX5 (/ISO)
Enzyme-directed rRNA pseudouridine synthesis GO:0000455
The intramolecular conversion of uridine to pseudouridine during ribosome biogenesis where the enzyme specifies the site that becomes pseudouridylated without using a guide RNA.
1 Q9ESX5 (/ISO)
Box H/ACA snoRNA 3'-end processing GO:0000495
Any process involved in forming the mature 3' end of a box H/ACA snoRNA molecule.
1 P33322 (/IMP)
Box H/ACA snoRNA 3'-end processing GO:0000495
Any process involved in forming the mature 3' end of a box H/ACA snoRNA molecule.
1 O14007 (/ISO)
TRNA modification GO:0006400
The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically.
1 Q38CM1 (/ISM)
Endocytosis GO:0006897
A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
1 O43100 (/IMP)
Telomere maintenance via telomerase GO:0007004
The maintenance of proper telomeric length by the addition of telomeric repeats by telomerase.
1 Q9ESX5 (/ISO)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
1 P40615 (/IDA)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
1 Q9ESX5 (/ISO)
Establishment of cell polarity GO:0030010
The specification and formation of anisotropic intracellular organization or cell growth patterns.
1 O43100 (/IMP)
RRNA pseudouridine synthesis GO:0031118
The intramolecular conversion of uridine to pseudouridine in an rRNA molecule.
1 O14007 (/ISO)
SnRNA pseudouridine synthesis GO:0031120
The intramolecular conversion of uridine to pseudouridine in an snRNA molecule.
1 P33322 (/IDA)
SnRNA pseudouridine synthesis GO:0031120
The intramolecular conversion of uridine to pseudouridine in an snRNA molecule.
1 P33322 (/IMP)
SnRNA pseudouridine synthesis GO:0031120
The intramolecular conversion of uridine to pseudouridine in an snRNA molecule.
1 O14007 (/ISO)
Positive regulation of telomere maintenance via telomerase GO:0032212
Any process that activates or increases the frequency, rate or extent of the addition of telomeric repeats by telomerase.
1 Q9ESX5 (/IMP)
Box H/ACA snoRNA metabolic process GO:0033979
The chemical reactions and pathways involving box H/ACA type small nucleolar RNA.
1 Q9ESX5 (/IMP)
Response to mercury ion GO:0046689
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercury ion stimulus.
1 Q54T81 (/IDA)
Conidium formation GO:0048315
The process of producing non-motile spores, called conidia, via mitotic asexual reproduction in higher fungi. Conidia are haploid cells genetically identical to their haploid parent. They are produced by conversion of hyphal elements, or are borne on sporogenous cells on or within specialized structures termed conidiophores, and participate in dispersal of the fungus.
1 O43100 (/IMP)
Anisotropic cell growth GO:0051211
The process in which a cell irreversibly increases in size in one or more axes, where the growth rate varies according to the direction of growth. Growth may be limited to a particular axis, axes, or to particular locations on the surface of the cell.
1 O43100 (/IMP)
Positive regulation of telomerase activity GO:0051973
Any process that activates or increases the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
1 Q9ESX5 (/ISO)
ScaRNA localization to Cajal body GO:0090666
A process in which a small Cajal body-specific RNA is transported to, or maintained in, a Cajal body.
1 Q9ESX5 (/ISO)
Telomerase RNA stabilization GO:0090669
Prevention of degradation of telomerase RNA (TERC) molecules.
1 Q9ESX5 (/ISO)
Positive regulation of establishment of protein localization to telomere GO:1904851
Any process that activates or increases the frequency, rate or extent of establishment of protein localization to telomere.
1 Q9ESX5 (/ISO)
Regulation of telomerase RNA localization to Cajal body GO:1904872
Any process that modulates the frequency, rate or extent of telomerase RNA localization to Cajal body.
1 Q9ESX5 (/ISO)
Positive regulation of telomerase RNA localization to Cajal body GO:1904874
Any process that activates or increases the frequency, rate or extent of telomerase RNA localization to Cajal body.
1 Q9ESX5 (/ISO)
MRNA pseudouridine synthesis GO:1990481
The intramolecular conversion of uridine to pseudouridine in an mRNA molecule.
1 P33322 (/IMP)

There are 31 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
7 O44081 (/IDA) O44081 (/IDA) P40615 (/IDA) Q9ESX5 (/IDA) Q9LD90 (/IDA) Q9LD90 (/IDA) Q9LD90 (/IDA)
Box H/ACA snoRNP complex GO:0031429
A box H/ACA RNP complex that is located in the nucleolus.
5 O60832 (/IDA) O60832 (/IDA) O60832 (/IDA) P33322 (/IDA) P40615 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
4 O60832 (/IDA) O60832 (/IDA) O60832 (/IDA) Q38CM1 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
4 O60832 (/TAS) O60832 (/TAS) O60832 (/TAS) Q5ZJH9 (/TAS)
Telomerase holoenzyme complex GO:0005697
Telomerase is a ribonucleoprotein enzyme complex, with a minimal catalytic core composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition. In vivo, the holoenzyme complex often contains additional subunits.
4 P40615 (/ISS) Q54T81 (/ISS) Q5ZJH9 (/ISS) Q9ESX5 (/ISS)
Fibrillar center GO:0001650
A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures.
3 O60832 (/IDA) O60832 (/IDA) O60832 (/IDA)
Telomerase holoenzyme complex GO:0005697
Telomerase is a ribonucleoprotein enzyme complex, with a minimal catalytic core composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition. In vivo, the holoenzyme complex often contains additional subunits.
3 O60832 (/IDA) O60832 (/IDA) O60832 (/IDA)
Telomerase holoenzyme complex GO:0005697
Telomerase is a ribonucleoprotein enzyme complex, with a minimal catalytic core composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition. In vivo, the holoenzyme complex often contains additional subunits.
3 O60832 (/TAS) O60832 (/TAS) O60832 (/TAS)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
3 O60832 (/TAS) O60832 (/TAS) O60832 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 Q9LD90 (/IDA) Q9LD90 (/IDA) Q9LD90 (/IDA)
Plasmodesma GO:0009506
A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell.
3 Q9LD90 (/IDA) Q9LD90 (/IDA) Q9LD90 (/IDA)
Box H/ACA snoRNP complex GO:0031429
A box H/ACA RNP complex that is located in the nucleolus.
3 O60832 (/TAS) O60832 (/TAS) O60832 (/TAS)
Box H/ACA scaRNP complex GO:0072589
A box H/ACA RNP complex that is located in the Cajal body of the nucleoplasm. In higher eukaryotes, box H/ACA RNP located in Cajal bodies mediate pseudouridylation of spliceosomal snRNAs.
3 O60832 (/TAS) O60832 (/TAS) O60832 (/TAS)
Box H/ACA telomerase RNP complex GO:0090661
A box H/ACA ribonucleoprotein complex that contains the RNA component of vertebrate telomerase, the enzyme essential for the replication of chromosome termini in most eukaryotes. This ribonucleoprotein complex is a structural box H/ACA RNP, which does not have the catalytic pseudouridylation function shared by the majority of H/ACA RNPs present in the cell.
3 O60832 (/IDA) O60832 (/IDA) O60832 (/IDA)
Box H/ACA telomerase RNP complex GO:0090661
A box H/ACA ribonucleoprotein complex that contains the RNA component of vertebrate telomerase, the enzyme essential for the replication of chromosome termini in most eukaryotes. This ribonucleoprotein complex is a structural box H/ACA RNP, which does not have the catalytic pseudouridylation function shared by the majority of H/ACA RNPs present in the cell.
3 O60832 (/TAS) O60832 (/TAS) O60832 (/TAS)
Cajal body GO:0015030
A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA.
2 P40615 (/IDA) Q9ESX5 (/IDA)
Box H/ACA snoRNP complex GO:0031429
A box H/ACA RNP complex that is located in the nucleolus.
2 O14007 (/ISO) Q9ESX5 (/ISO)
Fibrillar center GO:0001650
A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures.
1 Q9ESX5 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q38CM1 (/ISA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9ESX5 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 P40615 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q9ESX5 (/ISO)
Telomerase holoenzyme complex GO:0005697
Telomerase is a ribonucleoprotein enzyme complex, with a minimal catalytic core composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition. In vivo, the holoenzyme complex often contains additional subunits.
1 Q9ESX5 (/ISO)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
1 P33322 (/IC)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
1 Q9ESX5 (/ISO)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
1 Q54T81 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 O14007 (/HDA)
Cajal body GO:0015030
A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA.
1 Q9ESX5 (/ISO)
90S preribosome GO:0030686
A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.
1 P33322 (/HDA)
Box H/ACA snoRNP complex GO:0031429
A box H/ACA RNP complex that is located in the nucleolus.
1 P33322 (/IPI)
Box H/ACA telomerase RNP complex GO:0090661
A box H/ACA ribonucleoprotein complex that contains the RNA component of vertebrate telomerase, the enzyme essential for the replication of chromosome termini in most eukaryotes. This ribonucleoprotein complex is a structural box H/ACA RNP, which does not have the catalytic pseudouridylation function shared by the majority of H/ACA RNPs present in the cell.
1 Q9ESX5 (/ISO)