The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
GHMP Kinase, N-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 10: Exosome complex component RRP41

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
18 Q921I9 (/IPI) Q921I9 (/IPI) Q9NPD3 (/IPI) Q9NPD3 (/IPI) Q9NPD3 (/IPI) Q9NPD3 (/IPI) Q9NPD3 (/IPI) Q9NPD3 (/IPI) Q9NPD3 (/IPI) Q9NPD3 (/IPI)
(8 more)
3'-5'-exoribonuclease activity GO:0000175
Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule.
16 Q9NPD3 (/NAS) Q9NPD3 (/NAS) Q9NPD3 (/NAS) Q9NPD3 (/NAS) Q9NPD3 (/NAS) Q9NPD3 (/NAS) Q9NPD3 (/NAS) Q9NPD3 (/NAS) Q9NPD3 (/NAS) Q9NPD3 (/NAS)
(6 more)
MRNA 3'-UTR AU-rich region binding GO:0035925
Interacting selectively and non-covalently with a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule.
16 Q9NPD3 (/IDA) Q9NPD3 (/IDA) Q9NPD3 (/IDA) Q9NPD3 (/IDA) Q9NPD3 (/IDA) Q9NPD3 (/IDA) Q9NPD3 (/IDA) Q9NPD3 (/IDA) Q9NPD3 (/IDA) Q9NPD3 (/IDA)
(6 more)
MRNA 3'-UTR AU-rich region binding GO:0035925
Interacting selectively and non-covalently with a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule.
2 Q921I9 (/ISO) Q921I9 (/ISO)

There are 19 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Maturation of 5.8S rRNA GO:0000460
Any process involved in the maturation of a precursor 5.8S ribosomal RNA (rRNA) molecule into a mature 5.8S rRNA molecule.
16 Q9NPD3 (/IMP) Q9NPD3 (/IMP) Q9NPD3 (/IMP) Q9NPD3 (/IMP) Q9NPD3 (/IMP) Q9NPD3 (/IMP) Q9NPD3 (/IMP) Q9NPD3 (/IMP) Q9NPD3 (/IMP) Q9NPD3 (/IMP)
(6 more)
Nuclear-transcribed mRNA catabolic process GO:0000956
The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells.
16 Q9NPD3 (/IMP) Q9NPD3 (/IMP) Q9NPD3 (/IMP) Q9NPD3 (/IMP) Q9NPD3 (/IMP) Q9NPD3 (/IMP) Q9NPD3 (/IMP) Q9NPD3 (/IMP) Q9NPD3 (/IMP) Q9NPD3 (/IMP)
(6 more)
RRNA processing GO:0006364
Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.
16 Q9NPD3 (/NAS) Q9NPD3 (/NAS) Q9NPD3 (/NAS) Q9NPD3 (/NAS) Q9NPD3 (/NAS) Q9NPD3 (/NAS) Q9NPD3 (/NAS) Q9NPD3 (/NAS) Q9NPD3 (/NAS) Q9NPD3 (/NAS)
(6 more)
RRNA processing GO:0006364
Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.
16 Q9NPD3 (/TAS) Q9NPD3 (/TAS) Q9NPD3 (/TAS) Q9NPD3 (/TAS) Q9NPD3 (/TAS) Q9NPD3 (/TAS) Q9NPD3 (/TAS) Q9NPD3 (/TAS) Q9NPD3 (/TAS) Q9NPD3 (/TAS)
(6 more)
Positive regulation of cell growth GO:0030307
Any process that activates or increases the frequency, rate, extent or direction of cell growth.
16 Q9NPD3 (/IMP) Q9NPD3 (/IMP) Q9NPD3 (/IMP) Q9NPD3 (/IMP) Q9NPD3 (/IMP) Q9NPD3 (/IMP) Q9NPD3 (/IMP) Q9NPD3 (/IMP) Q9NPD3 (/IMP) Q9NPD3 (/IMP)
(6 more)
Regulation of mRNA stability GO:0043488
Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs.
16 Q9NPD3 (/TAS) Q9NPD3 (/TAS) Q9NPD3 (/TAS) Q9NPD3 (/TAS) Q9NPD3 (/TAS) Q9NPD3 (/TAS) Q9NPD3 (/TAS) Q9NPD3 (/TAS) Q9NPD3 (/TAS) Q9NPD3 (/TAS)
(6 more)
Exonucleolytic catabolism of deadenylated mRNA GO:0043928
The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 3'-poly(A) tail.
16 Q9NPD3 (/TAS) Q9NPD3 (/TAS) Q9NPD3 (/TAS) Q9NPD3 (/TAS) Q9NPD3 (/TAS) Q9NPD3 (/TAS) Q9NPD3 (/TAS) Q9NPD3 (/TAS) Q9NPD3 (/TAS) Q9NPD3 (/TAS)
(6 more)
DNA deamination GO:0045006
The removal of an amino group from a nucleotide base in DNA. An example is the deamination of cytosine to produce uracil.
16 Q9NPD3 (/IDA) Q9NPD3 (/IDA) Q9NPD3 (/IDA) Q9NPD3 (/IDA) Q9NPD3 (/IDA) Q9NPD3 (/IDA) Q9NPD3 (/IDA) Q9NPD3 (/IDA) Q9NPD3 (/IDA) Q9NPD3 (/IDA)
(6 more)
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
16 Q9NPD3 (/IMP) Q9NPD3 (/IMP) Q9NPD3 (/IMP) Q9NPD3 (/IMP) Q9NPD3 (/IMP) Q9NPD3 (/IMP) Q9NPD3 (/IMP) Q9NPD3 (/IMP) Q9NPD3 (/IMP) Q9NPD3 (/IMP)
(6 more)
Nuclear mRNA surveillance GO:0071028
The set of processes involved in identifying and degrading defective or aberrant mRNAs within the nucleus.
16 Q9NPD3 (/IMP) Q9NPD3 (/IMP) Q9NPD3 (/IMP) Q9NPD3 (/IMP) Q9NPD3 (/IMP) Q9NPD3 (/IMP) Q9NPD3 (/IMP) Q9NPD3 (/IMP) Q9NPD3 (/IMP) Q9NPD3 (/IMP)
(6 more)
Histone mRNA catabolic process GO:0071044
The chemical reactions and pathways resulting in the breakdown of histone messenger RNA (mRNA).
16 Q9NPD3 (/IMP) Q9NPD3 (/IMP) Q9NPD3 (/IMP) Q9NPD3 (/IMP) Q9NPD3 (/IMP) Q9NPD3 (/IMP) Q9NPD3 (/IMP) Q9NPD3 (/IMP) Q9NPD3 (/IMP) Q9NPD3 (/IMP)
(6 more)
Histone mRNA catabolic process GO:0071044
The chemical reactions and pathways resulting in the breakdown of histone messenger RNA (mRNA).
3 Q7YRA3 (/ISS) Q921I9 (/ISS) Q921I9 (/ISS)
Maturation of 5.8S rRNA GO:0000460
Any process involved in the maturation of a precursor 5.8S ribosomal RNA (rRNA) molecule into a mature 5.8S rRNA molecule.
2 Q921I9 (/ISO) Q921I9 (/ISO)
Nuclear-transcribed mRNA catabolic process GO:0000956
The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells.
2 Q921I9 (/ISO) Q921I9 (/ISO)
Positive regulation of cell growth GO:0030307
Any process that activates or increases the frequency, rate, extent or direction of cell growth.
2 Q921I9 (/ISO) Q921I9 (/ISO)
DNA deamination GO:0045006
The removal of an amino group from a nucleotide base in DNA. An example is the deamination of cytosine to produce uracil.
2 Q921I9 (/ISO) Q921I9 (/ISO)
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
2 Q921I9 (/ISO) Q921I9 (/ISO)
Nuclear mRNA surveillance GO:0071028
The set of processes involved in identifying and degrading defective or aberrant mRNAs within the nucleus.
2 Q921I9 (/ISO) Q921I9 (/ISO)
Histone mRNA catabolic process GO:0071044
The chemical reactions and pathways resulting in the breakdown of histone messenger RNA (mRNA).
2 Q921I9 (/ISO) Q921I9 (/ISO)

There are 17 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
17 E9PI41 (/IDA) Q9NPD3 (/IDA) Q9NPD3 (/IDA) Q9NPD3 (/IDA) Q9NPD3 (/IDA) Q9NPD3 (/IDA) Q9NPD3 (/IDA) Q9NPD3 (/IDA) Q9NPD3 (/IDA) Q9NPD3 (/IDA)
(7 more)
Intermediate filament cytoskeleton GO:0045111
Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell.
17 E9PI41 (/IDA) Q9NPD3 (/IDA) Q9NPD3 (/IDA) Q9NPD3 (/IDA) Q9NPD3 (/IDA) Q9NPD3 (/IDA) Q9NPD3 (/IDA) Q9NPD3 (/IDA) Q9NPD3 (/IDA) Q9NPD3 (/IDA)
(7 more)
Exosome (RNase complex) GO:0000178
A ribonuclease complex that has 3-prime to 5-prime exoribonuclease activity and possibly endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured.
16 Q9NPD3 (/IDA) Q9NPD3 (/IDA) Q9NPD3 (/IDA) Q9NPD3 (/IDA) Q9NPD3 (/IDA) Q9NPD3 (/IDA) Q9NPD3 (/IDA) Q9NPD3 (/IDA) Q9NPD3 (/IDA) Q9NPD3 (/IDA)
(6 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
16 Q9NPD3 (/IDA) Q9NPD3 (/IDA) Q9NPD3 (/IDA) Q9NPD3 (/IDA) Q9NPD3 (/IDA) Q9NPD3 (/IDA) Q9NPD3 (/IDA) Q9NPD3 (/IDA) Q9NPD3 (/IDA) Q9NPD3 (/IDA)
(6 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
16 Q9NPD3 (/TAS) Q9NPD3 (/TAS) Q9NPD3 (/TAS) Q9NPD3 (/TAS) Q9NPD3 (/TAS) Q9NPD3 (/TAS) Q9NPD3 (/TAS) Q9NPD3 (/TAS) Q9NPD3 (/TAS) Q9NPD3 (/TAS)
(6 more)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
16 Q9NPD3 (/NAS) Q9NPD3 (/NAS) Q9NPD3 (/NAS) Q9NPD3 (/NAS) Q9NPD3 (/NAS) Q9NPD3 (/NAS) Q9NPD3 (/NAS) Q9NPD3 (/NAS) Q9NPD3 (/NAS) Q9NPD3 (/NAS)
(6 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
16 Q9NPD3 (/IDA) Q9NPD3 (/IDA) Q9NPD3 (/IDA) Q9NPD3 (/IDA) Q9NPD3 (/IDA) Q9NPD3 (/IDA) Q9NPD3 (/IDA) Q9NPD3 (/IDA) Q9NPD3 (/IDA) Q9NPD3 (/IDA)
(6 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
16 Q9NPD3 (/NAS) Q9NPD3 (/NAS) Q9NPD3 (/NAS) Q9NPD3 (/NAS) Q9NPD3 (/NAS) Q9NPD3 (/NAS) Q9NPD3 (/NAS) Q9NPD3 (/NAS) Q9NPD3 (/NAS) Q9NPD3 (/NAS)
(6 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
16 Q9NPD3 (/TAS) Q9NPD3 (/TAS) Q9NPD3 (/TAS) Q9NPD3 (/TAS) Q9NPD3 (/TAS) Q9NPD3 (/TAS) Q9NPD3 (/TAS) Q9NPD3 (/TAS) Q9NPD3 (/TAS) Q9NPD3 (/TAS)
(6 more)
Transcriptionally active chromatin GO:0035327
The ordered and organized complex of DNA and protein that forms regions of the chromosome that are being actively transcribed.
16 Q9NPD3 (/IMP) Q9NPD3 (/IMP) Q9NPD3 (/IMP) Q9NPD3 (/IMP) Q9NPD3 (/IMP) Q9NPD3 (/IMP) Q9NPD3 (/IMP) Q9NPD3 (/IMP) Q9NPD3 (/IMP) Q9NPD3 (/IMP)
(6 more)
Exosome (RNase complex) GO:0000178
A ribonuclease complex that has 3-prime to 5-prime exoribonuclease activity and possibly endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured.
3 Q7YRA3 (/ISS) Q921I9 (/ISS) Q921I9 (/ISS)
Exosome (RNase complex) GO:0000178
A ribonuclease complex that has 3-prime to 5-prime exoribonuclease activity and possibly endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured.
2 Q921I9 (/ISO) Q921I9 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q921I9 (/ISO) Q921I9 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q921I9 (/ISO) Q921I9 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q921I9 (/ISO) Q921I9 (/ISO)
Transcriptionally active chromatin GO:0035327
The ordered and organized complex of DNA and protein that forms regions of the chromosome that are being actively transcribed.
2 Q921I9 (/ISO) Q921I9 (/ISO)
Intermediate filament cytoskeleton GO:0045111
Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell.
2 Q921I9 (/ISO) Q921I9 (/ISO)