The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

Scavenger mRNA decapping enzyme, N-terminal domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Scavenger mRNA decapping enzyme, N-terminal domain

Memebers of this superfamily share the structure of the N-terminal domain of the scavenger mRNA decapping enzyme (DcpS), involved in mRNA degradation via the 3' end decay pathway PMID:15068804. Here mRNA is degraded from the 3' end by the exosome complex following deadenylation with the resulting capped oligonucleotide, of ten nucleotides or fewer, being the substrate for this enzyme. DcpS exists as a dimer and each monomer is comprised of an N-terminal and a C-terminal region. The two N-termini form into a domain-swapped dimer and carry out substrate binding, cap dinucleotide, and hydrolysis PMID:16246173.

GO Diversity

Unique GO annotations
38 Unique GO terms

EC Diversity

Unique EC annotations
1 Unique EC terms

Species Diversity

Unique species annotations
1133 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 36
Domain clusters (>95% seq id): 3
Domain clusters (>35% seq id): 2
Unique PDBs: 13
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 14
Unique EC: 1
Unique GO: 38
Unique Species: 1133