The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Phosphorylase Kinase; domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 95: Mitogen-activated protein kinase kinase kinase 12

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 24 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
4 Q12852 (/ISS) Q12852 (/ISS) Q5R8X7 (/ISS) Q63796 (/ISS)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
4 Q12852 (/ISS) Q12852 (/ISS) Q5R8X7 (/ISS) Q63796 (/ISS)
JUN kinase kinase kinase activity GO:0004706
Catalysis of the reaction: JNKK + ATP = JNKK phosphate + ADP. This reaction is the phosphorylation and activation of JUN kinase kinases (JNKKs).
3 O43283 (/ISS) Q12852 (/ISS) Q12852 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 O43283 (/IPI) Q12852 (/IPI) Q12852 (/IPI)
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
2 Q12852 (/TAS) Q12852 (/TAS)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
2 O43283 (/IDA) Q60700 (/IDA)
JUN kinase kinase kinase activity GO:0004706
Catalysis of the reaction: JNKK + ATP = JNKK phosphate + ADP. This reaction is the phosphorylation and activation of JUN kinase kinases (JNKKs).
2 Q1HKZ5 (/IMP) Q60700 (/IMP)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
2 Q12852 (/IPI) Q12852 (/IPI)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 O43283 (/IDA) Q60700 (/IDA)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
1 Q1HKZ5 (/ISO)
MAP kinase kinase kinase activity GO:0004709
Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases.
1 O43283 (/IDA)
MAP kinase kinase kinase activity GO:0004709
Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases.
1 Q1HKZ5 (/ISO)
MAP kinase kinase kinase activity GO:0004709
Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases.
1 Q5R8X7 (/ISS)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
1 O43283 (/IPI)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
1 Q1HKZ5 (/ISO)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
1 Q60700 (/ISO)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
1 O43283 (/ISS)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
1 O01700 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 O43283 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q1HKZ5 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 Q1HKZ5 (/ISO)
IkappaB kinase complex binding GO:0106137
Interacting selectively and non-covalently with the IkappaB kinase complex.
1 O43283 (/IDA)
IkappaB kinase complex binding GO:0106137
Interacting selectively and non-covalently with the IkappaB kinase complex.
1 Q1HKZ5 (/ISO)
IkappaB kinase complex binding GO:0106137
Interacting selectively and non-covalently with the IkappaB kinase complex.
1 Q5R8X7 (/ISS)

There are 62 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
4 O43283 (/IDA) Q12852 (/IDA) Q12852 (/IDA) Q60700 (/IDA)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
4 Q12852 (/ISS) Q12852 (/ISS) Q5R8X7 (/ISS) Q63796 (/ISS)
Peptidyl-serine phosphorylation GO:0018105
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
4 O43283 (/ISS) Q12852 (/ISS) Q12852 (/ISS) Q63796 (/ISS)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
4 Q12852 (/ISS) Q12852 (/ISS) Q5R8X7 (/ISS) Q63796 (/ISS)
JNK cascade GO:0007254
An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
3 Q12852 (/ISS) Q12852 (/ISS) Q5R8X7 (/ISS)
Activation of JNKK activity GO:0007256
The initiation of the activity of the inactive enzyme JUN kinase kinase (JNKK) activity. JNKKs are involved in a signaling pathway that is primarily activated by cytokines and exposure to environmental stress.
3 O43283 (/ISS) Q12852 (/ISS) Q12852 (/ISS)
Activation of JUN kinase activity GO:0007257
The initiation of the activity of the inactive enzyme JUN kinase (JNK).
3 O43283 (/ISS) Q12852 (/ISS) Q12852 (/ISS)
Histone phosphorylation GO:0016572
The modification of histones by addition of phosphate groups.
3 Q12852 (/ISS) Q12852 (/ISS) Q63796 (/ISS)
Peptidyl-threonine phosphorylation GO:0018107
The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
3 Q12852 (/ISS) Q12852 (/ISS) Q63796 (/ISS)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
2 Q1HKZ5 (/ISO) Q60700 (/ISO)
Golgi organization GO:0007030
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus.
2 D3DMF6 (/IMP) Q9VW24 (/IMP)
JNK cascade GO:0007254
An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
2 Q12852 (/TAS) Q12852 (/TAS)
Activation of JNKK activity GO:0007256
The initiation of the activity of the inactive enzyme JUN kinase kinase (JNKK) activity. JNKKs are involved in a signaling pathway that is primarily activated by cytokines and exposure to environmental stress.
2 Q1HKZ5 (/IMP) Q60700 (/IMP)
Activation of JUN kinase activity GO:0007257
The initiation of the activity of the inactive enzyme JUN kinase (JNK).
2 Q1HKZ5 (/IMP) Q60700 (/IMP)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
2 D3DMF6 (/IMP) Q9VW24 (/IMP)
Long-term memory GO:0007616
The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.
2 D3DMF6 (/IGI) Q9VW24 (/IGI)
Peptidyl-serine phosphorylation GO:0018105
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
2 Q1HKZ5 (/IMP) Q60700 (/IMP)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
2 Q12852 (/TAS) Q12852 (/TAS)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
2 Q12852 (/IMP) Q12852 (/IMP)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
2 Q60700 (/ISS) Q63796 (/ISS)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
2 O43283 (/IDA) Q60700 (/IDA)
Collateral sprouting of injured axon GO:0048674
The process resulting in reformation of a growth cone by the tip of an injured axon, or in collateral sprouting of the axon. Collateral sprouting is the process in which outgrowths develop from the shafts of existing axons.
2 D3DMF6 (/IMP) Q9VW24 (/IMP)
Sprouting of injured axon GO:0048682
The process involved in sprouting of an injured axon.
2 D3DMF6 (/IMP) Q9VW24 (/IMP)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
2 Q12852 (/IMP) Q12852 (/IMP)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
2 Q60700 (/ISS) Q63796 (/ISS)
Regulation of terminal button organization GO:2000331
Any process that modulates the frequency, rate or extent of terminal button organization.
2 D3DMF6 (/IMP) Q9VW24 (/IMP)
Activation of MAPKK activity GO:0000186
The initiation of the activity of the inactive enzyme MAP kinase kinase (MAPKK).
1 O43283 (/IDA)
Activation of MAPKK activity GO:0000186
The initiation of the activity of the inactive enzyme MAP kinase kinase (MAPKK).
1 O01700 (/IGI)
Activation of MAPKK activity GO:0000186
The initiation of the activity of the inactive enzyme MAP kinase kinase (MAPKK).
1 Q1HKZ5 (/ISO)
Activation of MAPKK activity GO:0000186
The initiation of the activity of the inactive enzyme MAP kinase kinase (MAPKK).
1 Q5R8X7 (/ISS)
Activation of MAPK activity GO:0000187
The initiation of the activity of the inactive enzyme MAP kinase (MAPK).
1 O01700 (/IGI)
Activation of MAPK activity GO:0000187
The initiation of the activity of the inactive enzyme MAP kinase (MAPK).
1 O01700 (/IMP)
JNK cascade GO:0007254
An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
1 O43283 (/IDA)
JNK cascade GO:0007254
An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
1 Q1HKZ5 (/ISO)
Positive regulation of neuron maturation GO:0014042
Any process that activates or increases the frequency, rate or extent of neuron maturation.
1 Q1HKZ5 (/IMP)
Positive regulation of neuron maturation GO:0014042
Any process that activates or increases the frequency, rate or extent of neuron maturation.
1 O43283 (/ISS)
Histone phosphorylation GO:0016572
The modification of histones by addition of phosphate groups.
1 Q60700 (/IDA)
Peptidyl-serine phosphorylation GO:0018105
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
1 Q60700 (/IDA)
Peptidyl-threonine phosphorylation GO:0018107
The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
1 Q60700 (/IDA)
Axon regeneration GO:0031103
The regrowth of axons following their loss or damage.
1 O01700 (/IGI)
P38MAPK cascade GO:0038066
An intracellular protein kinase cascade containing at least a p38 MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
1 O01700 (/IMP)
Positive regulation of axon extension GO:0045773
Any process that activates or increases the frequency, rate or extent of axon extension.
1 O01700 (/IGI)
Positive regulation of axon extension GO:0045773
Any process that activates or increases the frequency, rate or extent of axon extension.
1 Q1HKZ5 (/IMP)
Positive regulation of axon extension GO:0045773
Any process that activates or increases the frequency, rate or extent of axon extension.
1 O43283 (/ISS)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 Q60700 (/ISO)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
1 Q1HKZ5 (/ISO)
Axon extension involved in regeneration GO:0048677
Long distance growth of a single axon process involved in regeneration of the neuron.
1 O01700 (/IMP)
Formation of growth cone in injured axon GO:0048689
The formation of a growth cone in an injured axon.
1 O01700 (/IMP)
Positive regulation of axon extension involved in regeneration GO:0048691
Any process that activates, maintains or increases the rate of axon extension involved in regeneration.
1 O01700 (/IMP)
Regulation of axon extension involved in axon guidance GO:0048841
Any process that modulates the frequency, rate or extent of axon extension involved in axon guidance.
1 O01700 (/IGI)
Regulation of synapse organization GO:0050807
Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
1 O01700 (/IGI)
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
1 O43283 (/IDA)
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
1 Q1HKZ5 (/ISO)
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
1 Q5R8X7 (/ISS)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
1 Q60700 (/ISO)
Medium-term memory GO:0072375
The memory process that deals with the storage, retrieval and modification of information received at a time ago that is intermediate between that of short and long term memory (30min - 7hrs in Drosophila melanogaster).
1 D3DMF6 (/IMP)
Positive regulation of neuron projection arborization GO:0150012
Any process that activates or increases the frequency, rate or extent of the process in which the anatomical structures of a neuron projection are generated and organized into branches.
1 Q1HKZ5 (/IMP)
Positive regulation of neuron projection arborization GO:0150012
Any process that activates or increases the frequency, rate or extent of the process in which the anatomical structures of a neuron projection are generated and organized into branches.
1 O43283 (/ISS)
Positive regulation of branching morphogenesis of a nerve GO:1905492
Any process that activates or increases the frequency, rate or extent of branching morphogenesis of a nerve.
1 Q1HKZ5 (/IMP)
Positive regulation of branching morphogenesis of a nerve GO:1905492
Any process that activates or increases the frequency, rate or extent of branching morphogenesis of a nerve.
1 O43283 (/ISS)
Regulation of 3'-UTR-mediated mRNA stabilization GO:1905868
Any process that modulates the frequency, rate or extent of 3'-UTR-mediated mRNA stabilization.
1 O01700 (/IGI)
Negative regulation of motor neuron apoptotic process GO:2000672
Any process that stops, prevents or reduces the frequency, rate or extent of motor neuron apoptotic process.
1 Q60700 (/IMP)

There are 13 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 Q12852 (/ISS) Q12852 (/ISS) Q63796 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 Q12852 (/ISS) Q12852 (/ISS) Q63796 (/ISS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
3 Q12852 (/ISS) Q12852 (/ISS) Q5R8X7 (/ISS)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
3 D3DMF6 (/IDA) Q60700 (/IDA) Q9VW24 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q12852 (/TAS) Q12852 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q12852 (/TAS) Q12852 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q60700 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q60700 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 O43283 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q1HKZ5 (/ISO)
Growth cone GO:0030426
The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
1 Q60700 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 O01700 (/IDA)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
1 O01700 (/IDA)