The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Phosphorylase Kinase; domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 80: Protein kinase C

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 41 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
21 P04409 (/IPI) P05696 (/IPI) P05696 (/IPI) P05696 (/IPI) P05771 (/IPI) P05771 (/IPI) P05771 (/IPI) P05771 (/IPI) P17252 (/IPI) P17252 (/IPI)
(11 more)
Protein kinase C activity GO:0004697
Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol.
16 P04409 (/IDA) P05696 (/IDA) P05696 (/IDA) P05696 (/IDA) P05771 (/IDA) P05771 (/IDA) P05771 (/IDA) P05771 (/IDA) P20444 (/IDA) P63319 (/IDA)
(6 more)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
9 A8KBH6 (/ISS) P05126 (/ISS) P05772 (/ISS) P68403 (/ISS) P68403 (/ISS) P68404 (/ISS) P68404 (/ISS) Q7LZQ8 (/ISS) Q7SY24 (/ISS)
Nuclear receptor transcription coactivator activity GO:0030374
The function of a transcription cofactor that activates transcription in conjuction with a ligand-dependent nuclear receptor from a RNA polymerase II promoter; does not bind DNA itself.
9 A8KBH6 (/ISS) P05126 (/ISS) P05772 (/ISS) P68403 (/ISS) P68403 (/ISS) P68404 (/ISS) P68404 (/ISS) Q7LZQ8 (/ISS) Q7SY24 (/ISS)
Histone kinase activity (H3-T6 specific) GO:0035403
Catalysis of the transfer of a phosphate group to the threonine-6 residue of the N-terminal tail of histone H3.
9 A8KBH6 (/ISS) P05126 (/ISS) P05772 (/ISS) P68403 (/ISS) P68403 (/ISS) P68404 (/ISS) P68404 (/ISS) Q7LZQ8 (/ISS) Q7SY24 (/ISS)
Histone binding GO:0042393
Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.
9 A8KBH6 (/ISS) P05126 (/ISS) P05772 (/ISS) P68403 (/ISS) P68403 (/ISS) P68404 (/ISS) P68404 (/ISS) Q7LZQ8 (/ISS) Q7SY24 (/ISS)
Androgen receptor binding GO:0050681
Interacting selectively and non-covalently with an androgen receptor.
9 A8KBH6 (/ISS) P05126 (/ISS) P05772 (/ISS) P68403 (/ISS) P68403 (/ISS) P68404 (/ISS) P68404 (/ISS) Q7LZQ8 (/ISS) Q7SY24 (/ISS)
Protein kinase C activity GO:0004697
Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol.
7 P05129 (/TAS) P05771 (/TAS) P05771 (/TAS) P05771 (/TAS) P05771 (/TAS) P17252 (/TAS) P17252 (/TAS)
Calcium-dependent protein kinase C activity GO:0004698
Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol and calcium.
7 P05696 (/IDA) P05696 (/IDA) P05696 (/IDA) P20444 (/IDA) P63319 (/IDA) P63319 (/IDA) P63319 (/IDA)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
6 P05771 (/EXP) P05771 (/EXP) P05771 (/EXP) P05771 (/EXP) P17252 (/EXP) P17252 (/EXP)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
6 P05771 (/TAS) P05771 (/TAS) P05771 (/TAS) P05771 (/TAS) P17252 (/TAS) P17252 (/TAS)
Protein kinase C activity GO:0004697
Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol.
6 P20444 (/ISO) P63318 (/ISO) P63318 (/ISO) P63318 (/ISO) P68404 (/ISO) P68404 (/ISO)
Histone kinase activity (H3-T6 specific) GO:0035403
Catalysis of the transfer of a phosphate group to the threonine-6 residue of the N-terminal tail of histone H3.
6 P05771 (/IDA) P05771 (/IDA) P05771 (/IDA) P05771 (/IDA) P17252 (/IDA) P17252 (/IDA)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
4 P05771 (/IDA) P05771 (/IDA) P05771 (/IDA) P05771 (/IDA)
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
4 P20444 (/ISO) P63318 (/ISO) P63318 (/ISO) P63318 (/ISO)
Protein kinase C activity GO:0004697
Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol.
4 P05126 (/ISS) P05772 (/ISS) P17252 (/ISS) P17252 (/ISS)
Calcium-dependent protein kinase C activity GO:0004698
Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol and calcium.
4 P20444 (/ISO) P63318 (/ISO) P63318 (/ISO) P63318 (/ISO)
Protein kinase C binding GO:0005080
Interacting selectively and non-covalently with protein kinase C.
4 P05771 (/IPI) P05771 (/IPI) P05771 (/IPI) P05771 (/IPI)
Nuclear receptor transcription coactivator activity GO:0030374
The function of a transcription cofactor that activates transcription in conjuction with a ligand-dependent nuclear receptor from a RNA polymerase II promoter; does not bind DNA itself.
4 P05771 (/IMP) P05771 (/IMP) P05771 (/IMP) P05771 (/IMP)
Histone binding GO:0042393
Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.
4 P05771 (/IDA) P05771 (/IDA) P05771 (/IDA) P05771 (/IDA)
Androgen receptor binding GO:0050681
Interacting selectively and non-covalently with an androgen receptor.
4 P05771 (/IDA) P05771 (/IDA) P05771 (/IDA) P05771 (/IDA)
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
3 P05129 (/IDA) P17252 (/IDA) P17252 (/IDA)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
3 P20444 (/IDA) P68404 (/IDA) P68404 (/IDA)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
3 P20444 (/ISO) P68404 (/ISO) P68404 (/ISO)
Protein kinase C activity GO:0004697
Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol.
3 A0A1D5PCZ1 (/IMP) A0A1D5PUY5 (/IMP) P20444 (/IMP)
Protein serine/threonine/tyrosine kinase activity GO:0004712
Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
3 P63318 (/ISO) P63318 (/ISO) P63318 (/ISO)
Histone kinase activity (H3-T6 specific) GO:0035403
Catalysis of the transfer of a phosphate group to the threonine-6 residue of the N-terminal tail of histone H3.
3 P20444 (/ISO) P68404 (/ISO) P68404 (/ISO)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
2 P68404 (/ISO) P68404 (/ISO)
Protein kinase C binding GO:0005080
Interacting selectively and non-covalently with protein kinase C.
2 P68404 (/ISO) P68404 (/ISO)
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
2 P17252 (/ISS) P17252 (/ISS)
Calcium channel regulator activity GO:0005246
Modulates the activity of a calcium channel.
2 P68404 (/IDA) P68404 (/IDA)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
2 P17252 (/IDA) P17252 (/IDA)
Nuclear receptor transcription coactivator activity GO:0030374
The function of a transcription cofactor that activates transcription in conjuction with a ligand-dependent nuclear receptor from a RNA polymerase II promoter; does not bind DNA itself.
2 P68404 (/ISO) P68404 (/ISO)
Histone binding GO:0042393
Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.
2 P68404 (/ISO) P68404 (/ISO)
Androgen receptor binding GO:0050681
Interacting selectively and non-covalently with an androgen receptor.
2 P68404 (/ISO) P68404 (/ISO)
Calcium-dependent protein kinase C activity GO:0004698
Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol and calcium.
1 P20444 (/IMP)
Protein serine/threonine/tyrosine kinase activity GO:0004712
Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
1 P05129 (/IDA)
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
1 P20444 (/IPI)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
1 P20444 (/ISO)
Syndecan binding GO:0045545
Interacting selectively and non-covalently with syndecan, an integral membrane proteoglycan (250-300 kDa) associated largely with epithelial cells.
1 G1N621 (/TAS)
Scaffold protein binding GO:0097110
Interacting selectively and non-covalently with a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes.
1 P04409 (/IPI)

There are 208 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of angiogenesis GO:0045766
Any process that activates or increases angiogenesis.
14 P04409 (/ISS) P05126 (/ISS) P05696 (/ISS) P05696 (/ISS) P05696 (/ISS) P05771 (/ISS) P05771 (/ISS) P05771 (/ISS) P05771 (/ISS) P05772 (/ISS)
(4 more)
B cell activation GO:0042113
The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
11 A8KBH6 (/ISS) P05126 (/ISS) P05771 (/ISS) P05771 (/ISS) P05771 (/ISS) P05771 (/ISS) P05772 (/ISS) P68403 (/ISS) P68403 (/ISS) Q7LZQ8 (/ISS)
(1 more)
Positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123
Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.
11 A8KBH6 (/ISS) P05126 (/ISS) P05771 (/ISS) P05771 (/ISS) P05771 (/ISS) P05771 (/ISS) P05772 (/ISS) P68403 (/ISS) P68403 (/ISS) Q7LZQ8 (/ISS)
(1 more)
B cell receptor signaling pathway GO:0050853
A series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell.
11 A8KBH6 (/ISS) P05126 (/ISS) P05771 (/ISS) P05771 (/ISS) P05771 (/ISS) P05771 (/ISS) P05772 (/ISS) P68403 (/ISS) P68403 (/ISS) Q7LZQ8 (/ISS)
(1 more)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
9 A8KBH6 (/ISS) P05126 (/ISS) P05772 (/ISS) P68403 (/ISS) P68403 (/ISS) P68404 (/ISS) P68404 (/ISS) Q7LZQ8 (/ISS) Q7SY24 (/ISS)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
9 P04409 (/IDA) P05696 (/IDA) P05696 (/IDA) P05696 (/IDA) P17252 (/IDA) P17252 (/IDA) P20444 (/IDA) P68404 (/IDA) P68404 (/IDA)
Histone H3-T6 phosphorylation GO:0035408
The modification of histone H3 by the addition of an phosphate group to a threonine residue at position 6 of the histone.
9 A8KBH6 (/ISS) P05126 (/ISS) P05772 (/ISS) P68403 (/ISS) P68403 (/ISS) P68404 (/ISS) P68404 (/ISS) Q7LZQ8 (/ISS) Q7SY24 (/ISS)
Negative regulation of glucose transmembrane transport GO:0010829
Any process that decreases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
8 P05126 (/ISS) P05771 (/ISS) P05771 (/ISS) P05771 (/ISS) P05771 (/ISS) P05772 (/ISS) P68403 (/ISS) P68403 (/ISS)
Positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949
Any process that activates or increases the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity.
8 P05126 (/ISS) P05771 (/ISS) P05771 (/ISS) P05771 (/ISS) P05771 (/ISS) P05772 (/ISS) P68403 (/ISS) P68403 (/ISS)
Negative regulation of insulin receptor signaling pathway GO:0046627
Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling.
8 P05126 (/ISS) P05771 (/ISS) P05771 (/ISS) P05771 (/ISS) P05771 (/ISS) P05772 (/ISS) P68404 (/ISS) P68404 (/ISS)
Positive regulation of B cell receptor signaling pathway GO:0050861
Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell.
8 P05126 (/ISS) P05771 (/ISS) P05771 (/ISS) P05771 (/ISS) P05771 (/ISS) P05772 (/ISS) P68403 (/ISS) P68403 (/ISS)
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
8 P05126 (/ISS) P05771 (/ISS) P05771 (/ISS) P05771 (/ISS) P05771 (/ISS) P05772 (/ISS) P68403 (/ISS) P68403 (/ISS)
Platelet activation GO:0030168
A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.
7 P05129 (/TAS) P05771 (/TAS) P05771 (/TAS) P05771 (/TAS) P05771 (/TAS) P17252 (/TAS) P17252 (/TAS)
Regulation of response to food GO:0032095
Any process that modulates the frequency, rate or extent of a response to a food stimulus.
7 P05128 (/ISS) P05129 (/ISS) P10829 (/ISS) P63319 (/ISS) P63319 (/ISS) P63319 (/ISS) Q4R4U2 (/ISS)
Regulation of circadian rhythm GO:0042752
Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
7 P05128 (/ISS) P05129 (/ISS) P10829 (/ISS) P63319 (/ISS) P63319 (/ISS) P63319 (/ISS) Q4R4U2 (/ISS)
Response to morphine GO:0043278
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a morphine stimulus. Morphine is an opioid alkaloid, isolated from opium, with a complex ring structure.
7 P05128 (/ISS) P05129 (/ISS) P10829 (/ISS) P63319 (/ISS) P63319 (/ISS) P63319 (/ISS) Q4R4U2 (/ISS)
Negative regulation of neuron apoptotic process GO:0043524
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.
7 P05128 (/ISS) P05129 (/ISS) P10829 (/ISS) P63318 (/ISS) P63318 (/ISS) P63318 (/ISS) Q4R4U2 (/ISS)
Positive regulation of macrophage differentiation GO:0045651
Any process that activates or increases the frequency, rate or extent of macrophage differentiation.
7 P04409 (/ISS) P05696 (/ISS) P05696 (/ISS) P05696 (/ISS) P10102 (/ISS) P17252 (/ISS) P17252 (/ISS)
Response to pain GO:0048265
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli.
7 P05128 (/ISS) P05129 (/ISS) P10829 (/ISS) P63319 (/ISS) P63319 (/ISS) P63319 (/ISS) Q4R4U2 (/ISS)
Negative regulation of proteasomal protein catabolic process GO:1901799
Any process that stops, prevents or reduces the frequency, rate or extent of proteasomal protein catabolic process.
7 P05128 (/ISS) P05129 (/ISS) P10829 (/ISS) P63319 (/ISS) P63319 (/ISS) P63319 (/ISS) Q4R4U2 (/ISS)
Positive regulation of dense core granule biogenesis GO:2000707
Any process that activates or increases the frequency, rate or extent of dense core granule biogenesis.
7 P04409 (/ISS) P05696 (/ISS) P05696 (/ISS) P05696 (/ISS) P10102 (/ISS) P17252 (/ISS) P17252 (/ISS)
Positive regulation of endothelial cell proliferation GO:0001938
Any process that activates or increases the rate or extent of endothelial cell proliferation.
6 P04409 (/ISS) P05696 (/ISS) P05696 (/ISS) P05696 (/ISS) P10102 (/ISS) P20444 (/ISS)
Mitotic nuclear envelope disassembly GO:0007077
The cell cycle process in which the controlled breakdown of the nuclear envelope during mitotic cell division occurs.
6 P05771 (/TAS) P05771 (/TAS) P05771 (/TAS) P05771 (/TAS) P17252 (/TAS) P17252 (/TAS)
Positive regulation of endothelial cell migration GO:0010595
Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
6 P04409 (/ISS) P05696 (/ISS) P05696 (/ISS) P05696 (/ISS) P10102 (/ISS) P20444 (/ISS)
Regulation of glucose transmembrane transport GO:0010827
Any process that modulates the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
6 P05126 (/ISS) P05772 (/ISS) P68403 (/ISS) P68403 (/ISS) P68404 (/ISS) P68404 (/ISS)
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
6 P04409 (/ISS) P05696 (/ISS) P05696 (/ISS) P05696 (/ISS) P10102 (/ISS) P20444 (/ISS)
Negative regulation of protein ubiquitination GO:0031397
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein.
6 P05128 (/ISS) P10829 (/ISS) P63319 (/ISS) P63319 (/ISS) P63319 (/ISS) Q4R4U2 (/ISS)
Positive regulation of lipopolysaccharide-mediated signaling pathway GO:0031666
Any process that activates or increases the frequency, rate or extent of signaling in response to detection of lipopolysaccharide.
6 P04409 (/ISS) P05696 (/ISS) P05696 (/ISS) P05696 (/ISS) P10102 (/ISS) P20444 (/ISS)
Negative regulation of glial cell apoptotic process GO:0034351
Any process that stops, prevents, or reduces the frequency, rate, or extent of glial cell apoptotic process.
6 P04409 (/ISS) P05696 (/ISS) P05696 (/ISS) P05696 (/ISS) P10102 (/ISS) P20444 (/ISS)
Histone H3-T6 phosphorylation GO:0035408
The modification of histone H3 by the addition of an phosphate group to a threonine residue at position 6 of the histone.
6 P05771 (/IDA) P05771 (/IDA) P05771 (/IDA) P05771 (/IDA) P17252 (/IDA) P17252 (/IDA)
Positive regulation of cell adhesion GO:0045785
Any process that activates or increases the frequency, rate or extent of cell adhesion.
6 P04409 (/ISS) P05696 (/ISS) P05696 (/ISS) P05696 (/ISS) P10102 (/ISS) P20444 (/ISS)
Positive regulation of mitotic cell cycle GO:0045931
Any process that activates or increases the rate or extent of progression through the mitotic cell cycle.
6 P04409 (/ISS) P05696 (/ISS) P05696 (/ISS) P05696 (/ISS) P10102 (/ISS) P20444 (/ISS)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
6 P05696 (/IDA) P05696 (/IDA) P05696 (/IDA) P63319 (/IDA) P63319 (/IDA) P63319 (/IDA)
Presynaptic modulation of chemical synaptic transmission GO:0099171
Any process, acting in the presynapse that results in modulation of chemical synaptic transmission.
6 P20444 (/IDA) P63318 (/IDA) P63318 (/IDA) P63318 (/IDA) P68404 (/IDA) P68404 (/IDA)
Presynaptic modulation of chemical synaptic transmission GO:0099171
Any process, acting in the presynapse that results in modulation of chemical synaptic transmission.
6 P20444 (/IMP) P63318 (/IMP) P63318 (/IMP) P63318 (/IMP) P68404 (/IMP) P68404 (/IMP)
Regulation of synaptic vesicle exocytosis GO:2000300
Any process that modulates the frequency, rate or extent of synaptic vesicle exocytosis.
6 P20444 (/IDA) P63318 (/IDA) P63318 (/IDA) P63318 (/IDA) P68404 (/IDA) P68404 (/IDA)
Regulation of synaptic vesicle exocytosis GO:2000300
Any process that modulates the frequency, rate or extent of synaptic vesicle exocytosis.
6 P20444 (/IMP) P63318 (/IMP) P63318 (/IMP) P63318 (/IMP) P68404 (/IMP) P68404 (/IMP)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
5 P05129 (/TAS) P05771 (/TAS) P05771 (/TAS) P05771 (/TAS) P05771 (/TAS)
Positive regulation of cardiac muscle hypertrophy GO:0010613
Any process that increases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division.
5 P04409 (/ISS) P10102 (/ISS) P17252 (/ISS) P17252 (/ISS) P20444 (/ISS)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
5 P63319 (/NAS) P63319 (/NAS) P63319 (/NAS) P68403 (/NAS) P68403 (/NAS)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
5 P04409 (/ISS) P10102 (/ISS) P17252 (/ISS) P17252 (/ISS) P20444 (/ISS)
Regulation of platelet aggregation GO:0090330
Any process that modulates the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules.
5 P04409 (/ISS) P05696 (/ISS) P05696 (/ISS) P05696 (/ISS) P10102 (/ISS)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
4 P05771 (/IMP) P05771 (/IMP) P05771 (/IMP) P05771 (/IMP)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
4 P05771 (/NAS) P05771 (/NAS) P05771 (/NAS) P05771 (/NAS)
Regulation of glucose transmembrane transport GO:0010827
Any process that modulates the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
4 P05771 (/IDA) P05771 (/IDA) P05771 (/IDA) P05771 (/IDA)
Lipoprotein transport GO:0042953
The directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
4 P05771 (/TAS) P05771 (/TAS) P05771 (/TAS) P05771 (/TAS)
Regulation of myeloid cell differentiation GO:0045637
Any process that modulates the frequency, rate or extent of myeloid cell differentiation.
4 P05771 (/TAS) P05771 (/TAS) P05771 (/TAS) P05771 (/TAS)
Positive regulation of angiogenesis GO:0045766
Any process that activates or increases angiogenesis.
4 P17252 (/IMP) P17252 (/IMP) P68404 (/IMP) P68404 (/IMP)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
4 P20444 (/ISO) P63318 (/ISO) P63318 (/ISO) P63318 (/ISO)
B cell receptor signaling pathway GO:0050853
A series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell.
4 A0A1D5PCZ1 (/IMP) A0A1D5PUY5 (/IMP) P68404 (/IMP) P68404 (/IMP)
Response to reactive oxygen species GO:0000302
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.
3 P05696 (/IMP) P05696 (/IMP) P05696 (/IMP)
Chemical synaptic transmission GO:0007268
The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
3 P63318 (/IMP) P63318 (/IMP) P63318 (/IMP)
Chemical synaptic transmission GO:0007268
The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
3 P63319 (/NAS) P63319 (/NAS) P63319 (/NAS)
Aging GO:0007568
A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
3 P05696 (/IEP) P05696 (/IEP) P05696 (/IEP)
Learning or memory GO:0007611
The acquisition and processing of information and/or the storage and retrieval of this information over time.
3 P63319 (/IEP) P63319 (/IEP) P63319 (/IEP)
Learning or memory GO:0007611
The acquisition and processing of information and/or the storage and retrieval of this information over time.
3 P05696 (/IMP) P05696 (/IMP) P05696 (/IMP)
Chemosensory behavior GO:0007635
Behavior that is dependent upon the sensation of chemicals.
3 P63318 (/IMP) P63318 (/IMP) P63318 (/IMP)
Response to mechanical stimulus GO:0009612
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.
3 P05696 (/IEP) P05696 (/IEP) P05696 (/IEP)
Response to toxic substance GO:0009636
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.
3 P05696 (/IEP) P05696 (/IEP) P05696 (/IEP)
Positive regulation of cardiac muscle hypertrophy GO:0010613
Any process that increases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division.
3 P05696 (/IDA) P05696 (/IDA) P05696 (/IDA)
Response to organic cyclic compound GO:0014070
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
3 P05696 (/IEP) P05696 (/IEP) P05696 (/IEP)
Phosphorylation GO:0016310
The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
3 P63318 (/ISO) P63318 (/ISO) P63318 (/ISO)
Negative regulation of translation GO:0017148
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
3 P05696 (/IMP) P05696 (/IMP) P05696 (/IMP)
Peptidyl-serine phosphorylation GO:0018105
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
3 P05696 (/IDA) P05696 (/IDA) P05696 (/IDA)
Peptidyl-threonine phosphorylation GO:0018107
The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
3 P05696 (/IDA) P05696 (/IDA) P05696 (/IDA)
Peptidyl-threonine phosphorylation GO:0018107
The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
3 P05696 (/IMP) P05696 (/IMP) P05696 (/IMP)
Central nervous system neuron axonogenesis GO:0021955
Generation of a long process from a neuron whose cell body resides in the central nervous system. The process carries efferent (outgoing) action potentials from the cell body towards target cells.
3 P05696 (/IMP) P05696 (/IMP) P05696 (/IMP)
Negative regulation of protein ubiquitination GO:0031397
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein.
3 P63318 (/IMP) P63318 (/IMP) P63318 (/IMP)
Negative regulation of protein ubiquitination GO:0031397
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein.
3 P63318 (/ISO) P63318 (/ISO) P63318 (/ISO)
Regulation of response to food GO:0032095
Any process that modulates the frequency, rate or extent of a response to a food stimulus.
3 P63318 (/IMP) P63318 (/IMP) P63318 (/IMP)
Response to estradiol GO:0032355
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
3 P05696 (/IMP) P05696 (/IMP) P05696 (/IMP)
Positive regulation of mismatch repair GO:0032425
Any process that activates or increases the frequency, rate or extent of mismatch repair.
3 P63318 (/ISO) P63318 (/ISO) P63318 (/ISO)
Histone H3-T6 phosphorylation GO:0035408
The modification of histone H3 by the addition of an phosphate group to a threonine residue at position 6 of the histone.
3 P20444 (/ISO) P68404 (/ISO) P68404 (/ISO)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
3 P05696 (/IDA) P05696 (/IDA) P05696 (/IDA)
Negative regulation of protein catabolic process GO:0042177
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
3 P63318 (/ISO) P63318 (/ISO) P63318 (/ISO)
Regulation of circadian rhythm GO:0042752
Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
3 P63318 (/IMP) P63318 (/IMP) P63318 (/IMP)
Response to morphine GO:0043278
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a morphine stimulus. Morphine is an opioid alkaloid, isolated from opium, with a complex ring structure.
3 P63318 (/IMP) P63318 (/IMP) P63318 (/IMP)
Response to peptide hormone GO:0043434
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.
3 P05696 (/IEP) P05696 (/IEP) P05696 (/IEP)
Negative regulation of neuron apoptotic process GO:0043524
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.
3 P63319 (/IMP) P63319 (/IMP) P63319 (/IMP)
Negative regulation of neuron apoptotic process GO:0043524
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.
3 P63318 (/ISO) P63318 (/ISO) P63318 (/ISO)
Establishment of protein localization GO:0045184
The directed movement of a protein to a specific location.
3 P05696 (/TAS) P05696 (/TAS) P05696 (/TAS)
Response to ethanol GO:0045471
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
3 P05696 (/IMP) P05696 (/IMP) P05696 (/IMP)
Negative regulation of heart contraction GO:0045822
Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction.
3 P05696 (/IMP) P05696 (/IMP) P05696 (/IMP)
Positive regulation of exocytosis GO:0045921
Any process that activates or increases the frequency, rate or extent of exocytosis.
3 P05696 (/IMP) P05696 (/IMP) P05696 (/IMP)
Response to antibiotic GO:0046677
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.
3 P05696 (/IEP) P05696 (/IEP) P05696 (/IEP)
Regulation of receptor-mediated endocytosis GO:0048259
Any process that modulates the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport.
3 P05696 (/IMP) P05696 (/IMP) P05696 (/IMP)
Response to pain GO:0048265
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli.
3 P63318 (/IMP) P63318 (/IMP) P63318 (/IMP)
Positive regulation of smooth muscle cell proliferation GO:0048661
Any process that activates or increases the rate or extent of smooth muscle cell proliferation.
3 P05696 (/IMP) P05696 (/IMP) P05696 (/IMP)
Regulation of phagocytosis GO:0050764
Any process that modulates the frequency, rate or extent of phagocytosis, the process in which phagocytes engulf external particulate material.
3 P63318 (/IMP) P63318 (/IMP) P63318 (/IMP)
Response to corticosterone GO:0051412
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosterone stimulus. Corticosterone is a 21 carbon steroid hormone of the corticosteroid type, produced in the cortex of the adrenal glands. In many species, corticosterone is the principal glucocorticoid, involved in regulation of fuel metabolism, immune reactions, and stress responses.
3 P05696 (/IEP) P05696 (/IEP) P05696 (/IEP)
Positive regulation of synapse assembly GO:0051965
Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.
3 P05696 (/IMP) P05696 (/IMP) P05696 (/IMP)
Innervation GO:0060384
The process in which a nerve invades a tissue and makes functional synaptic connection within the tissue.
3 P63318 (/IMP) P63318 (/IMP) P63318 (/IMP)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
3 P05696 (/IMP) P05696 (/IMP) P05696 (/IMP)
Cellular response to carbohydrate stimulus GO:0071322
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus.
3 P20444 (/IDA) P68404 (/IDA) P68404 (/IDA)
Negative regulation of proteasomal protein catabolic process GO:1901799
Any process that stops, prevents or reduces the frequency, rate or extent of proteasomal protein catabolic process.
3 P63318 (/IMP) P63318 (/IMP) P63318 (/IMP)
Response to psychosocial stress GO:1990911
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of exposure to aversive or demanding psychological and social conditions that tax or exceed the behavioral resources of the organism.
3 P63319 (/IDA) P63319 (/IDA) P63319 (/IDA)
Response to psychosocial stress GO:1990911
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of exposure to aversive or demanding psychological and social conditions that tax or exceed the behavioral resources of the organism.
3 P63318 (/ISO) P63318 (/ISO) P63318 (/ISO)
Positive regulation of endothelial cell proliferation GO:0001938
Any process that activates or increases the rate or extent of endothelial cell proliferation.
2 P17252 (/IMP) P17252 (/IMP)
Desmosome assembly GO:0002159
A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm.
2 P17252 (/IMP) P17252 (/IMP)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
2 P68404 (/ISO) P68404 (/ISO)
Calcium ion transport GO:0006816
The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 P68404 (/IDA) P68404 (/IDA)
Cellular calcium ion homeostasis GO:0006874
Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.
2 P68404 (/IDA) P68404 (/IDA)
I-kappaB kinase/NF-kappaB signaling GO:0007249
The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
2 A0A1D5PCZ1 (/IMP) A0A1D5PUY5 (/IMP)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
2 P17252 (/TAS) P17252 (/TAS)
Blood coagulation GO:0007596
The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.
2 A0A2R8QIY5 (/IMP) Q7SY24 (/IMP)
Response to glucose GO:0009749
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
2 P68403 (/IEP) P68403 (/IEP)
Positive regulation of endothelial cell migration GO:0010595
Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
2 P17252 (/IMP) P17252 (/IMP)
Negative regulation of glucose transmembrane transport GO:0010829
Any process that decreases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 P68404 (/IMP) P68404 (/IMP)
Regulation of dopamine secretion GO:0014059
Any process that modulates the frequency, rate or extent of the regulated release of dopamine.
2 P68403 (/IMP) P68403 (/IMP)
Regulation of dopamine secretion GO:0014059
Any process that modulates the frequency, rate or extent of the regulated release of dopamine.
2 P68404 (/ISO) P68404 (/ISO)
Peptidyl-serine phosphorylation GO:0018105
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
2 P17252 (/TAS) P17252 (/TAS)
Peptidyl-threonine phosphorylation GO:0018107
The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
2 P17252 (/ISS) P17252 (/ISS)
Dibenzo-p-dioxin metabolic process GO:0018894
The chemical reactions and pathways involving dibenzo-p-dioxin, a substance composed of two benzene rings linked by two ether bonds. Dibenzo-p-dioxins are generated as by-products in the manufacturing of herbicides, insecticides, fungicides, paper pulp bleaching, and in incineration, and can accumulate in milk and throughout the food chain, creating significant health concern.
2 P68403 (/IEP) P68403 (/IEP)
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
2 P17252 (/IMP) P17252 (/IMP)
Positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949
Any process that activates or increases the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity.
2 P68404 (/IMP) P68404 (/IMP)
Positive regulation of lipopolysaccharide-mediated signaling pathway GO:0031666
Any process that activates or increases the frequency, rate or extent of signaling in response to detection of lipopolysaccharide.
2 P17252 (/IMP) P17252 (/IMP)
Response to vitamin D GO:0033280
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin D stimulus.
2 P68403 (/IEP) P68403 (/IEP)
Negative regulation of glial cell apoptotic process GO:0034351
Any process that stops, prevents, or reduces the frequency, rate, or extent of glial cell apoptotic process.
2 P17252 (/IMP) P17252 (/IMP)
ERBB2 signaling pathway GO:0038128
A series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptors on the surface of a cell, where the signal is transmitted by ERBB2. The pathway ends with regulation of a downstream cellular process, e.g. transcription. ERBB2 receptors are themselves unable to bind to ligands, but act as a signal-amplifying tyrosine kinase within a heterodimeric pair.
2 P17252 (/TAS) P17252 (/TAS)
Regulation of growth GO:0040008
Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development.
2 P68403 (/IMP) P68403 (/IMP)
Regulation of growth GO:0040008
Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development.
2 P68404 (/ISO) P68404 (/ISO)
B cell activation GO:0042113
The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
2 P68404 (/IMP) P68404 (/IMP)
Positive regulation of odontogenesis of dentin-containing tooth GO:0042488
Any process that activates or increases the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages that are borne on the jaws, or on other bones in the walls of the mouth or pharynx of most vertebrates.
2 P68403 (/IEP) P68403 (/IEP)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
2 P68403 (/IMP) P68403 (/IMP)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
2 P68404 (/ISO) P68404 (/ISO)
Positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123
Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.
2 P68404 (/IMP) P68404 (/IMP)
Regulation of mRNA stability GO:0043488
Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs.
2 P17252 (/TAS) P17252 (/TAS)
Positive regulation of blood vessel endothelial cell migration GO:0043536
Any process that activates or increases the frequency, rate or extent of the migration of the endothelial cells of blood vessels.
2 P17252 (/IDA) P17252 (/IDA)
Response to ethanol GO:0045471
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
2 P68403 (/IEP) P68403 (/IEP)
Positive regulation of bone resorption GO:0045780
Any process that activates or increases the frequency, rate or extent of bone resorption.
2 P17252 (/ISS) P17252 (/ISS)
Positive regulation of cell adhesion GO:0045785
Any process that activates or increases the frequency, rate or extent of cell adhesion.
2 P17252 (/IMP) P17252 (/IMP)
Positive regulation of mitotic cell cycle GO:0045931
Any process that activates or increases the rate or extent of progression through the mitotic cell cycle.
2 P17252 (/IMP) P17252 (/IMP)
Negative regulation of insulin receptor signaling pathway GO:0046627
Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling.
2 P68403 (/IDA) P68403 (/IDA)
Negative regulation of insulin receptor signaling pathway GO:0046627
Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling.
2 P68404 (/ISO) P68404 (/ISO)
Regulation of insulin secretion GO:0050796
Any process that modulates the frequency, rate or extent of the regulated release of insulin.
2 P17252 (/TAS) P17252 (/TAS)
Positive regulation of B cell receptor signaling pathway GO:0050861
Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell.
2 P68404 (/IMP) P68404 (/IMP)
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
2 P68404 (/IMP) P68404 (/IMP)
Response to interleukin-1 GO:0070555
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.
2 P17252 (/IMP) P17252 (/IMP)
Regulation of platelet aggregation GO:0090330
Any process that modulates the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules.
2 P17252 (/IDA) P17252 (/IDA)
Apoptotic signaling pathway GO:0097190
A series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered.
2 P17252 (/TAS) P17252 (/TAS)
Positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0106071
Any process that activates or increases the frequency, rate or extent of an adenylate cyclase-activating G protein-coupled receptor signaling pathway.
2 P17252 (/ISS) P17252 (/ISS)
Inactivation of MAPK activity GO:0000188
Any process that terminates the activity of the active enzyme MAP kinase.
1 P20444 (/IMP)
Response to reactive oxygen species GO:0000302
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.
1 P20444 (/ISO)
Receptor recycling GO:0001881
The process that results in the return of receptor molecules to an active state and an active cellular location after they have been stimulated by a ligand. An active state is when the receptor is ready to receive a signal.
1 F1QJU6 (/IDA)
Negative regulation of protein phosphorylation GO:0001933
Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.
1 P20444 (/IGI)
Negative regulation of protein phosphorylation GO:0001933
Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.
1 P20444 (/IMP)
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
1 P20444 (/IMP)
Positive regulation of endothelial cell proliferation GO:0001938
Any process that activates or increases the rate or extent of endothelial cell proliferation.
1 P20444 (/ISO)
Regulation of the force of heart contraction GO:0002026
Any process that modulates the extent of heart contraction, changing the force with which blood is propelled.
1 P20444 (/IMP)
Chondrocyte differentiation GO:0002062
The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage.
1 P20444 (/IDA)
Desmosome assembly GO:0002159
A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm.
1 P20444 (/ISO)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
1 P20444 (/ISO)
Negative regulation of protein kinase activity GO:0006469
Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity.
1 P20444 (/IMP)
Cellular calcium ion homeostasis GO:0006874
Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.
1 P20444 (/IMP)
Regulation of muscle contraction GO:0006937
Any process that modulates the frequency, rate or extent of muscle contraction.
1 P20444 (/IMP)
Learning or memory GO:0007611
The acquisition and processing of information and/or the storage and retrieval of this information over time.
1 P20444 (/ISO)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 P20444 (/IGI)
Negative regulation of anion channel activity GO:0010360
Any process that stops, prevents, or reduces the frequency, rate, or extent of the anion channel activity.
1 P20444 (/IMP)
Gene expression GO:0010467
The process in which a gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q5F3X1 (/IMP)
Gene expression GO:0010467
The process in which a gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 G1N621 (/TAS)
Positive regulation of endothelial cell migration GO:0010595
Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
1 P20444 (/ISO)
Positive regulation of cardiac muscle hypertrophy GO:0010613
Any process that increases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division.
1 P20444 (/ISO)
Phosphorylation GO:0016310
The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
1 P05129 (/IDA)
Negative regulation of translation GO:0017148
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
1 P20444 (/ISO)
Peptidyl-serine phosphorylation GO:0018105
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
1 A0A1D5PCZ1 (/IMP)
Peptidyl-serine phosphorylation GO:0018105
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
1 P20444 (/ISO)
Peptidyl-threonine phosphorylation GO:0018107
The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
1 P20444 (/ISO)
Central nervous system neuron axonogenesis GO:0021955
Generation of a long process from a neuron whose cell body resides in the central nervous system. The process carries efferent (outgoing) action potentials from the cell body towards target cells.
1 P20444 (/ISO)
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
1 P20444 (/ISO)
Neutrophil chemotaxis GO:0030593
The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.
1 P20444 (/IMP)
Negative regulation of protein ubiquitination GO:0031397
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein.
1 P05129 (/IDA)
Positive regulation of lipopolysaccharide-mediated signaling pathway GO:0031666
Any process that activates or increases the frequency, rate or extent of signaling in response to detection of lipopolysaccharide.
1 P20444 (/ISO)
Response to estradiol GO:0032355
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
1 P20444 (/ISO)
Positive regulation of mismatch repair GO:0032425
Any process that activates or increases the frequency, rate or extent of mismatch repair.
1 P05129 (/IDA)
Negative regulation of glial cell apoptotic process GO:0034351
Any process that stops, prevents, or reduces the frequency, rate, or extent of glial cell apoptotic process.
1 P20444 (/ISO)
Embryonic hemopoiesis GO:0035162
The stages of blood cell formation that take place within the embryo.
1 Q7SY24 (/IMP)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
1 P20444 (/ISO)
Peptidyl-serine autophosphorylation GO:0036289
The phosphorylation by a protein of one or more of its own serine amino acid residues, or a serine residue on an identical protein.
1 P20444 (/IDA)
Negative regulation of protein catabolic process GO:0042177
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
1 P05129 (/IDA)
Positive regulation of blood vessel endothelial cell migration GO:0043536
Any process that activates or increases the frequency, rate or extent of the migration of the endothelial cells of blood vessels.
1 P20444 (/ISO)
Response to ethanol GO:0045471
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
1 P20444 (/ISO)
Positive regulation of macrophage differentiation GO:0045651
Any process that activates or increases the frequency, rate or extent of macrophage differentiation.
1 P20444 (/IMP)
Positive regulation of angiogenesis GO:0045766
Any process that activates or increases angiogenesis.
1 P20444 (/ISO)
Positive regulation of bone resorption GO:0045780
Any process that activates or increases the frequency, rate or extent of bone resorption.
1 P20444 (/IMP)
Positive regulation of cell adhesion GO:0045785
Any process that activates or increases the frequency, rate or extent of cell adhesion.
1 P20444 (/ISO)
Negative regulation of heart contraction GO:0045822
Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction.
1 P20444 (/ISO)
Positive regulation of exocytosis GO:0045921
Any process that activates or increases the frequency, rate or extent of exocytosis.
1 P20444 (/ISO)
Positive regulation of mitotic cell cycle GO:0045931
Any process that activates or increases the rate or extent of progression through the mitotic cell cycle.
1 P20444 (/ISO)
Negative regulation of glucose import GO:0046325
Any process that stops, prevents, or reduces the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle.
1 P20444 (/IMP)
Negative regulation of insulin receptor signaling pathway GO:0046627
Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling.
1 P20444 (/IMP)
Regulation of response to osmotic stress GO:0047484
Any process that modulates the rate or extent of the response to osmotic stress.
1 P20444 (/IMP)
Regulation of receptor-mediated endocytosis GO:0048259
Any process that modulates the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport.
1 P20444 (/ISO)
Positive regulation of smooth muscle cell proliferation GO:0048661
Any process that activates or increases the rate or extent of smooth muscle cell proliferation.
1 P20444 (/ISO)
Positive regulation of inflammatory response GO:0050729
Any process that activates or increases the frequency, rate or extent of the inflammatory response.
1 P20444 (/IMP)
Regulation of peptidyl-tyrosine phosphorylation GO:0050730
Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
1 P20444 (/IMP)
Induction of positive chemotaxis GO:0050930
Any process that initiates the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical.
1 P20444 (/IMP)
Positive regulation of synapse assembly GO:0051965
Any process that activates, maintains or increases the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse.
1 P20444 (/ISO)
Synapse maturation GO:0060074
The process that organizes a synapse so that it attains its fully functional state. Synaptic maturation plays a critical role in the establishment of effective synaptic connections in early development.
1 F1QJU6 (/IMP)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
1 P20444 (/ISO)
Prolactin secretion GO:0070459
The regulated release of prolactin, a peptide hormone that stimulates lactation, from secretory granules in the anterior pituitary.
1 Q5F3X1 (/IMP)
Prolactin secretion GO:0070459
The regulated release of prolactin, a peptide hormone that stimulates lactation, from secretory granules in the anterior pituitary.
1 G1N621 (/TAS)
Response to interleukin-1 GO:0070555
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.
1 P20444 (/ISO)
Cellular response to staurosporine GO:0072734
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a staurosporine stimulus.
1 G1N621 (/IDA)
Regulation of platelet aggregation GO:0090330
Any process that modulates the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules.
1 P20444 (/IMP)
Regulation of platelet aggregation GO:0090330
Any process that modulates the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules.
1 P20444 (/ISO)
Intrinsic apoptotic signaling pathway GO:0097193
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP).
1 P20444 (/IMP)
Positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0106071
Any process that activates or increases the frequency, rate or extent of an adenylate cyclase-activating G protein-coupled receptor signaling pathway.
1 P04409 (/IDA)
Positive regulation of dense core granule biogenesis GO:2000707
Any process that activates or increases the frequency, rate or extent of dense core granule biogenesis.
1 P20444 (/IMP)

There are 57 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
47 A0A091FNS9 (/ISS) A0A096NTX9 (/ISS) A0A096NTX9 (/ISS) A0A096NTX9 (/ISS) A0A096NTX9 (/ISS) A0A096NTX9 (/ISS) A0A096NTX9 (/ISS) A0JM65 (/ISS) B0JYP1 (/ISS) B5DFC4 (/ISS)
(37 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
21 G1N621 (/IDA) L7RSM7 (/IDA) L7RSM7 (/IDA) P05696 (/IDA) P05696 (/IDA) P05696 (/IDA) P05771 (/IDA) P05771 (/IDA) P05771 (/IDA) P05771 (/IDA)
(11 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
16 L7RSM7 (/IDA) L7RSM7 (/IDA) P05696 (/IDA) P05696 (/IDA) P05696 (/IDA) P05771 (/IDA) P05771 (/IDA) P05771 (/IDA) P05771 (/IDA) P17252 (/IDA)
(6 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
12 P05771 (/IDA) P05771 (/IDA) P05771 (/IDA) P05771 (/IDA) P17252 (/IDA) P17252 (/IDA) P20444 (/IDA) P63318 (/IDA) P63318 (/IDA) P63318 (/IDA)
(2 more)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
12 P04409 (/ISS) P05128 (/ISS) P05129 (/ISS) P10102 (/ISS) P10829 (/ISS) P17252 (/ISS) P17252 (/ISS) P20444 (/ISS) P63318 (/ISS) P63318 (/ISS)
(2 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
10 P05771 (/IDA) P05771 (/IDA) P05771 (/IDA) P05771 (/IDA) P20444 (/IDA) P63318 (/IDA) P63318 (/IDA) P63318 (/IDA) P68404 (/IDA) P68404 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
9 A8KBH6 (/ISS) P05126 (/ISS) P05772 (/ISS) P68403 (/ISS) P68403 (/ISS) P68404 (/ISS) P68404 (/ISS) Q7LZQ8 (/ISS) Q7SY24 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
9 P04409 (/ISS) P05128 (/ISS) P05129 (/ISS) P10102 (/ISS) P10829 (/ISS) P63318 (/ISS) P63318 (/ISS) P63318 (/ISS) Q4R4U2 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
9 P05129 (/TAS) P05771 (/TAS) P05771 (/TAS) P05771 (/TAS) P05771 (/TAS) P17252 (/TAS) P17252 (/TAS) P20444 (/TAS) Q6AZF7 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
7 P05771 (/TAS) P05771 (/TAS) P05771 (/TAS) P05771 (/TAS) P17252 (/TAS) P17252 (/TAS) Q6AZF7 (/TAS)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
7 P20444 (/IDA) P63318 (/IDA) P63318 (/IDA) P63318 (/IDA) P63319 (/IDA) P63319 (/IDA) P63319 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
6 P05771 (/TAS) P05771 (/TAS) P05771 (/TAS) P05771 (/TAS) P17252 (/TAS) P17252 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
6 P20444 (/ISO) P63318 (/ISO) P63318 (/ISO) P63318 (/ISO) P68404 (/ISO) P68404 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
6 P20444 (/ISO) P63318 (/ISO) P63318 (/ISO) P63318 (/ISO) P68404 (/ISO) P68404 (/ISO)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
6 P05696 (/IDA) P05696 (/IDA) P05696 (/IDA) P63319 (/IDA) P63319 (/IDA) P63319 (/IDA)
Calyx of Held GO:0044305
The terminal specialization of a calyciferous axon which forms large synapses in the mammalian auditory central nervous system.
6 P20444 (/IDA) P63318 (/IDA) P63318 (/IDA) P63318 (/IDA) P68404 (/IDA) P68404 (/IDA)
Calyx of Held GO:0044305
The terminal specialization of a calyciferous axon which forms large synapses in the mammalian auditory central nervous system.
6 P20444 (/IMP) P63318 (/IMP) P63318 (/IMP) P63318 (/IMP) P68404 (/IMP) P68404 (/IMP)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
6 P05696 (/IDA) P05696 (/IDA) P05696 (/IDA) P63319 (/IDA) P63319 (/IDA) P63319 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
6 P05771 (/HDA) P05771 (/HDA) P05771 (/HDA) P05771 (/HDA) P17252 (/HDA) P17252 (/HDA)
Presynaptic cytosol GO:0099523
The region of the cytosol consisting of all cytosol that is part of the presynapse.
6 P20444 (/IDA) P63318 (/IDA) P63318 (/IDA) P63318 (/IDA) P68404 (/IDA) P68404 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
5 P04409 (/ISS) P05696 (/ISS) P05696 (/ISS) P05696 (/ISS) P10102 (/ISS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
4 P05771 (/IDA) P05771 (/IDA) P05771 (/IDA) P05771 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
4 P05696 (/IDA) P05696 (/IDA) P05696 (/IDA) P20444 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
4 P05696 (/IDA) P05696 (/IDA) P05696 (/IDA) P20444 (/IDA)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
4 P20444 (/ISO) P63318 (/ISO) P63318 (/ISO) P63318 (/ISO)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
4 P20444 (/ISO) P63318 (/ISO) P63318 (/ISO) P63318 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 P20444 (/ISO) P68404 (/ISO) P68404 (/ISO)
Cell-cell junction GO:0005911
A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.
3 P63318 (/IDA) P63318 (/IDA) P63318 (/IDA)
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
3 P63318 (/IDA) P63318 (/IDA) P63318 (/IDA)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
3 P63318 (/ISO) P63318 (/ISO) P63318 (/ISO)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
3 P05128 (/ISS) P05129 (/ISS) P10829 (/ISS)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
3 P05696 (/IDA) P05696 (/IDA) P05696 (/IDA)
Synaptic membrane GO:0097060
A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.
3 P63318 (/IDA) P63318 (/IDA) P63318 (/IDA)
Postsynaptic cytosol GO:0099524
The region of the cytosol consisting of all cytosol that is part of the postsynapse.
3 P63319 (/IDA) P63319 (/IDA) P63319 (/IDA)
Postsynaptic cytosol GO:0099524
The region of the cytosol consisting of all cytosol that is part of the postsynapse.
3 P63318 (/ISO) P63318 (/ISO) P63318 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 P68404 (/ISO) P68404 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 P68404 (/ISO) P68404 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 P17252 (/HDA) P17252 (/HDA)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
2 P17252 (/IDA) P17252 (/IDA)
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
2 P68403 (/IDA) P68403 (/IDA)
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
2 P68404 (/ISO) P68404 (/ISO)
Brush border membrane GO:0031526
The portion of the plasma membrane surrounding the brush border.
2 P68403 (/IDA) P68403 (/IDA)
Brush border membrane GO:0031526
The portion of the plasma membrane surrounding the brush border.
2 P68404 (/ISO) P68404 (/ISO)
Alphav-beta3 integrin-PKCalpha complex GO:0035866
A protein complex that consists of an alphav-beta3 integrin complex bound to protein kinase C alpha.
2 P17252 (/ISS) P17252 (/ISS)
Photoreceptor outer segment GO:0001750
The outer segment of a vertebrate photoreceptor that contains a stack of membrane discs embedded with photoreceptor proteins.
1 P20444 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 P20444 (/ISO)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
1 P20444 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 G1N621 (/IMP)
Intercalated disc GO:0014704
A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells.
1 P20444 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 P20444 (/IDA)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
1 P20444 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 P20444 (/ISO)
Alphav-beta3 integrin-PKCalpha complex GO:0035866
A protein complex that consists of an alphav-beta3 integrin complex bound to protein kinase C alpha.
1 P20444 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 P20444 (/IDA)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
1 P20444 (/ISO)
Apical part of cell GO:0045177
The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.
1 P20444 (/IDA)
Photoreceptor disc membrane GO:0097381
Stack of disc membranes located inside a photoreceptor outer segment, and containing densely packed molecules of photoreceptor proteins that traverse the lipid bilayer. Disc membranes arise as evaginations of the ciliary membrane during the development of the outer segment and may or may not remain contiguous with the ciliary membrane.
1 P04409 (/TAS)