The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Phosphorylase Kinase; domain 1
".
FunFam 341: MAP kinase kinase PBS2
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 10 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
MAP kinase kinase activity GO:0004708
Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate.
|
9 | A0A1D8PKE2 (/IMP) P08018 (/IMP) P08018 (/IMP) P08018 (/IMP) P08018 (/IMP) P08018 (/IMP) P33886 (/IMP) Q5BEU9 (/IMP) Q5BEU9 (/IMP) |
|
MAP kinase kinase activity GO:0004708
Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate.
|
6 | A0A1D8PKE2 (/ISS) P08018 (/ISS) P08018 (/ISS) P08018 (/ISS) P08018 (/ISS) P08018 (/ISS) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
6 | P08018 (/IPI) P08018 (/IPI) P08018 (/IPI) P08018 (/IPI) P08018 (/IPI) P33886 (/IPI) |
|
Peptide alpha-N-acetyltransferase activity GO:0004596
Catalysis of the reaction: acetyl-CoA + peptide = CoA + N-alpha-acetylpeptide. This reaction is the acetylation of the N-terminal amino acid residue of a peptide or protein.
|
5 | P08018 (/IMP) P08018 (/IMP) P08018 (/IMP) P08018 (/IMP) P08018 (/IMP) |
|
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
|
5 | P08018 (/HDA) P08018 (/HDA) P08018 (/HDA) P08018 (/HDA) P08018 (/HDA) |
|
MAP-kinase scaffold activity GO:0005078
The binding activity of a molecule that functions as a physical support for the assembly of a multiprotein mitogen-activated protein kinase (MAPK) complex. Binds multiple kinases of the MAPKKK cascade, and also upstream signaling proteins, permitting those molecules to function in a coordinated way. Bringing together multiple enzymes and their substrates enables the signal to be transduced quickly and efficiently.
|
5 | P08018 (/IPI) P08018 (/IPI) P08018 (/IPI) P08018 (/IPI) P08018 (/IPI) |
|
MAP kinase kinase activity GO:0004708
Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate.
|
2 | Q5BEU9 (/IGI) Q5BEU9 (/IGI) |
|
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
|
1 | P33886 (/IDA) |
|
MAP kinase kinase activity GO:0004708
Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate.
|
1 | P33886 (/IDA) |
|
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
|
1 | P33886 (/ISM) |
There are 24 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
6 | A0A1D8PKE2 (/IMP) P08018 (/IMP) P08018 (/IMP) P08018 (/IMP) P08018 (/IMP) P08018 (/IMP) |
|
Cellular response to heat GO:0034605
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
|
6 | P08018 (/IMP) P08018 (/IMP) P08018 (/IMP) P08018 (/IMP) P08018 (/IMP) P33886 (/IMP) |
|
Activation of MAPK activity GO:0000187
The initiation of the activity of the inactive enzyme MAP kinase (MAPK).
|
5 | P08018 (/IGI) P08018 (/IGI) P08018 (/IGI) P08018 (/IGI) P08018 (/IGI) |
|
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
5 | P08018 (/HDA) P08018 (/HDA) P08018 (/HDA) P08018 (/HDA) P08018 (/HDA) |
|
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
5 | P08018 (/IDA) P08018 (/IDA) P08018 (/IDA) P08018 (/IDA) P08018 (/IDA) |
|
Protein import into nucleus GO:0006606
The directed movement of a protein from the cytoplasm to the nucleus.
|
5 | P08018 (/IMP) P08018 (/IMP) P08018 (/IMP) P08018 (/IMP) P08018 (/IMP) |
|
Hyperosmotic response GO:0006972
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell.
|
5 | P08018 (/IMP) P08018 (/IMP) P08018 (/IMP) P08018 (/IMP) P08018 (/IMP) |
|
Actin filament organization GO:0007015
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.
|
5 | P08018 (/IMP) P08018 (/IMP) P08018 (/IMP) P08018 (/IMP) P08018 (/IMP) |
|
Osmosensory signaling pathway GO:0007231
The series of molecular signals initiated in response to osmotic change.
|
5 | P08018 (/IDA) P08018 (/IDA) P08018 (/IDA) P08018 (/IDA) P08018 (/IDA) |
|
Osmosensory signaling pathway GO:0007231
The series of molecular signals initiated in response to osmotic change.
|
5 | P08018 (/IMP) P08018 (/IMP) P08018 (/IMP) P08018 (/IMP) P08018 (/IMP) |
|
Cellular hyperosmotic response GO:0071474
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell.
|
3 | A0A1D8PKE2 (/IMP) Q5BEU9 (/IMP) Q5BEU9 (/IMP) |
|
Activation of MAPK activity involved in osmosensory signaling pathway GO:0000169
Any process that initiates the activity of the inactive enzyme MAP kinase activity during osmolarity sensing.
|
2 | Q5BEU9 (/IGI) Q5BEU9 (/IGI) |
|
Activation of MAPK activity involved in osmosensory signaling pathway GO:0000169
Any process that initiates the activity of the inactive enzyme MAP kinase activity during osmolarity sensing.
|
2 | Q5BEU9 (/IMP) Q5BEU9 (/IMP) |
|
Hyperosmotic response GO:0006972
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell.
|
2 | Q5BEU9 (/IGI) Q5BEU9 (/IGI) |
|
Cellular response to osmotic stress GO:0071470
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.
|
2 | A0A1D8PKE2 (/IMP) P33886 (/IMP) |
|
Positive regulation of G2/M transition of mitotic cell cycle GO:0010971
Any signalling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle.
|
1 | P33886 (/IMP) |
|
Filamentous growth GO:0030447
The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape.
|
1 | A0A1D8PKE2 (/IMP) |
|
Stress-activated protein kinase signaling cascade GO:0031098
A series of molecular signals in which a stress-activated protein kinase (SAPK) cascade relays one or more of the signals.
|
1 | A0A1D8PKE2 (/IMP) |
|
Fungal-type cell wall organization GO:0031505
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fungal-type cell wall.
|
1 | A0A1D8PKE2 (/IMP) |
|
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
|
1 | P33886 (/IMP) |
|
Positive regulation of protein import into nucleus GO:0042307
Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus.
|
1 | P33886 (/IMP) |
|
Stress-activated MAPK cascade GO:0051403
A series of molecular signals in which a stress-activated MAP kinase cascade relays one or more of the signals; MAP kinase cascades involve at least three protein kinase activities and culminate in the phosphorylation and activation of a MAP kinase.
|
1 | P33886 (/IDA) |
|
Stress-activated MAPK cascade GO:0051403
A series of molecular signals in which a stress-activated MAP kinase cascade relays one or more of the signals; MAP kinase cascades involve at least three protein kinase activities and culminate in the phosphorylation and activation of a MAP kinase.
|
1 | P33886 (/IMP) |
|
Cellular response to osmotic stress GO:0071470
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.
|
1 | P33886 (/IDA) |
There are 9 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
6 | P08018 (/IDA) P08018 (/IDA) P08018 (/IDA) P08018 (/IDA) P08018 (/IDA) P33886 (/IDA) |
|
Cellular bud tip GO:0005934
The end of a cellular bud distal to the site of attachment to the mother cell.
|
5 | P08018 (/IDA) P08018 (/IDA) P08018 (/IDA) P08018 (/IDA) P08018 (/IDA) |
|
Cellular bud neck GO:0005935
The constriction between the mother cell and daughter cell (bud) in an organism that reproduces by budding.
|
5 | P08018 (/IDA) P08018 (/IDA) P08018 (/IDA) P08018 (/IDA) P08018 (/IDA) |
|
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
|
5 | P08018 (/IDA) P08018 (/IDA) P08018 (/IDA) P08018 (/IDA) P08018 (/IDA) |
|
NatB complex GO:0031416
A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Glu, Met-Asp, Met-Asn, or Met-Met N-terminus. In Saccharomyces the complex includes Nat3p and Mdm20p.
|
5 | P08018 (/IDA) P08018 (/IDA) P08018 (/IDA) P08018 (/IDA) P08018 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | P33886 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | P33886 (/HDA) |
|
Mcs4 RR-MAPKKK complex GO:1990315
A protein complex that consists of a phospho relay component and a MAPK cascade component. The complex is involved in signaling oxidative stress and osmostress.
|
1 | P33886 (/IDA) |
|
Mcs4 RR-MAPKKK complex GO:1990315
A protein complex that consists of a phospho relay component and a MAPK cascade component. The complex is involved in signaling oxidative stress and osmostress.
|
1 | P33886 (/IPI) |